ID   Q92P33_RHIME            Unreviewed;       725 AA.
AC   Q92P33;
DT   01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT   01-DEC-2001, sequence version 1.
DT   27-MAR-2024, entry version 95.
DE   SubName: Full=Adenylate/guanylate cyclase transmembrane protein {ECO:0000313|EMBL:CAC46540.1};
DE            EC=4.6.1.1 {ECO:0000313|EMBL:CAC46540.1};
GN   Name=cyaD2 {ECO:0000313|EMBL:CAC46540.1};
GN   ORFNames=SMc04307 {ECO:0000313|EMBL:CAC46540.1};
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834 {ECO:0000313|EMBL:CAC46540.1, ECO:0000313|Proteomes:UP000001976};
RN   [1] {ECO:0000313|EMBL:CAC46540.1, ECO:0000313|Proteomes:UP000001976}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021 {ECO:0000313|EMBL:CAC46540.1,
RC   ECO:0000313|Proteomes:UP000001976};
RX   PubMed=11481430; DOI=10.1073/pnas.161294398;
RA   Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA   Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA   Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA   Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA   Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT   "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT   meliloti strain 1021.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN   [2] {ECO:0000313|Proteomes:UP000001976}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021 {ECO:0000313|Proteomes:UP000001976};
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
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DR   EMBL; AL591688; CAC46540.1; -; Genomic_DNA.
DR   RefSeq; NP_386067.1; NC_003047.1.
DR   RefSeq; WP_010969598.1; NC_003047.1.
DR   AlphaFoldDB; Q92P33; -.
DR   EnsemblBacteria; CAC46540; CAC46540; SMc04307.
DR   GeneID; 61603429; -.
DR   KEGG; sme:SMc04307; -.
DR   PATRIC; fig|266834.11.peg.3410; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG4252; Bacteria.
DR   HOGENOM; CLU_000445_85_1_5; -.
DR   OrthoDB; 9789782at2; -.
DR   Proteomes; UP000001976; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR007890; CHASE2.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF05226; CHASE2; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM01080; CHASE2; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000313|EMBL:CAC46540.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001976};
KW   Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:CAC46540.1};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        348..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        374..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        405..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          466..600
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   725 AA;  77627 MW;  2C8F762B20739033 CRC64;
     MARTQLVGVI IGLAIVAALT VLRATDPPLL RLARDLTFDE YQRLAPRSFE NVPVRVVDID
     EASLKEFGQW PWPRDRVAAL VDRLSEIGAA AIAFDILFSE PDRLSPRSVM RDVAGVDQAL
     LKRLPDNDEI LARSIGDRPV VLGFGLTNAG NYRPPVKAGF AFTGESPFDA PPRLTAATPL
     RPQLEARAAG LGHISLNPGS RSAVVRSVPL LLSDGEQLYP NLALEALRVA QGASTYIVAG
     APDAPDTITL IKVGEFVVPV TAAGELWLYV SPDRAERYVS AGRVLAPGGV SAETRAAIEG
     GIVFVGTSAA GLQDIRTTAL GHNVPGVSLH AQTVEQVLSG RFLSRPDWAD GLEILAIAAA
     GSLLVLLTTF VSPAVALACG LLITALALVA SWSAFLYAGL LFDPLAPILA GSITHFAATA
     YRFLVIDRER RVVRRAFGQY LSPSLLYRIE HTQDALRLGG DDRELTIMFV DVRNFTEISE
     RLTPGEVVRF LNTLLDALSR HVIANEGTLD KFIGDSIMAF WNAPVDVADH PGKAVRAALA
     MRETLARLNE SDAFGFGSDQ KVAIGVGIHT GLACVGNMGA EMHFNYSAVG DAVNIAARIE
     AACKDVGFDI LISETTADLG ERCAVLEAGA LALKGKSTRT RVYAVVGDEH MAASAEFSEL
     QRIHEQLIGA MRSRSRPRRE LVNAAKLKAP ALCGGLSDFY RRIGRRTDHF AGEPLPFADE
     VGSAE
//