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Q92N42

- FTHS_RHIME

UniProt

Q92N42 - FTHS_RHIME

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, R02390, SMc02728
Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-2445-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:R02390
ORF Names:SMc02728
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000199372Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc02728.

Structurei

3D structure databases

ProteinModelPortaliQ92N42.
SMRiQ92N42. Positions 7-557.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92N42-1 [UniParc]FASTAAdd to Basket

« Hide

MGEVKSDIEI ARAARKQPIM EVGAKLGIPP EHLLPYGHDK AKVSAEFIAA    50
QNEKRNGRLI LVTAINPTPA GEGKTTTTVG LGDGLNRIGK KAIVCIREAS 100
LGPCFGIKGG AAGGGYAQVV PMEDINLHFT GDFHAITSAH NLLSALIDNH 150
IYWGNEQAID IRRIAWRRVM DMNDRALRQI VGSLGGVANG YPRETGFDIT 200
VASEVMAILC LAMDIKDLEK RLGNIIIGYR RDKSPVFARD IKADGAMAVL 250
LKDAMQPNLV QTLENNPAFV HGGPFANIAH GCNSVVATTT ALKLADYVVT 300
EAGFGADLGA EKFFDIKCRK AGLTPDAAVI VATVRAIKMN GGVKREDLGR 350
ESVEAVRKGC ANLGRHIQNV KKFGVPVLVA INHFTSDTEA EVRAIKDYVR 400
TLGSEAVLCK HWAEGSAGIE ELAYKVVDLA NAGHSQFSPL YPDEMPLFQK 450
IETIAKDIYH ASEVIADKLV REQLRTWEDQ GYGDLPICMA KTQYSFSTDP 500
NLRGAPTGHA VPIREVRLAA GAGFIVVITG EIMTMPGLPK VPSSERIRLN 550
EQGYIEGLF 559
Length:559
Mass (Da):60,412
Last modified:December 6, 2005 - v2
Checksum:i5B877C0EDBF1FF13
GO

Sequence cautioni

The sequence CAC46969.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591688 Genomic DNA. Translation: CAC46969.1. Different initiation.
RefSeqiNP_386496.2. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC46969; CAC46969; SMc02728.
GeneIDi1234057.
KEGGisme:SMc02728.
PATRICi23634273. VBISinMel96828_3874.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591688 Genomic DNA. Translation: CAC46969.1 . Different initiation.
RefSeqi NP_386496.2. NC_003047.1.

3D structure databases

ProteinModelPortali Q92N42.
SMRi Q92N42. Positions 7-557.
ModBasei Search...

Protein-protein interaction databases

STRINGi 266834.SMc02728.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC46969 ; CAC46969 ; SMc02728 .
GeneIDi 1234057.
KEGGi sme:SMc02728.
PATRICi 23634273. VBISinMel96828_3874.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SMEL266834:GJF6-2445-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiFTHS_RHIME
AccessioniPrimary (citable) accession number: Q92N42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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