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Q92N42

- FTHS_RHIME

UniProt

Q92N42 - FTHS_RHIME

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 2 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi68 – 758ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSMEL266834:GJF6-2445-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:R02390
    ORF Names:SMc02728
    OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
    Taxonomic identifieri266834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001976: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_0000199372Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266834.SMc02728.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92N42.
    SMRiQ92N42. Positions 7-557.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92N42-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEVKSDIEI ARAARKQPIM EVGAKLGIPP EHLLPYGHDK AKVSAEFIAA    50
    QNEKRNGRLI LVTAINPTPA GEGKTTTTVG LGDGLNRIGK KAIVCIREAS 100
    LGPCFGIKGG AAGGGYAQVV PMEDINLHFT GDFHAITSAH NLLSALIDNH 150
    IYWGNEQAID IRRIAWRRVM DMNDRALRQI VGSLGGVANG YPRETGFDIT 200
    VASEVMAILC LAMDIKDLEK RLGNIIIGYR RDKSPVFARD IKADGAMAVL 250
    LKDAMQPNLV QTLENNPAFV HGGPFANIAH GCNSVVATTT ALKLADYVVT 300
    EAGFGADLGA EKFFDIKCRK AGLTPDAAVI VATVRAIKMN GGVKREDLGR 350
    ESVEAVRKGC ANLGRHIQNV KKFGVPVLVA INHFTSDTEA EVRAIKDYVR 400
    TLGSEAVLCK HWAEGSAGIE ELAYKVVDLA NAGHSQFSPL YPDEMPLFQK 450
    IETIAKDIYH ASEVIADKLV REQLRTWEDQ GYGDLPICMA KTQYSFSTDP 500
    NLRGAPTGHA VPIREVRLAA GAGFIVVITG EIMTMPGLPK VPSSERIRLN 550
    EQGYIEGLF 559
    Length:559
    Mass (Da):60,412
    Last modified:December 6, 2005 - v2
    Checksum:i5B877C0EDBF1FF13
    GO

    Sequence cautioni

    The sequence CAC46969.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591688 Genomic DNA. Translation: CAC46969.1. Different initiation.
    RefSeqiNP_386496.2. NC_003047.1.

    Genome annotation databases

    EnsemblBacteriaiCAC46969; CAC46969; SMc02728.
    GeneIDi1234057.
    KEGGisme:SMc02728.
    PATRICi23634273. VBISinMel96828_3874.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591688 Genomic DNA. Translation: CAC46969.1 . Different initiation.
    RefSeqi NP_386496.2. NC_003047.1.

    3D structure databases

    ProteinModelPortali Q92N42.
    SMRi Q92N42. Positions 7-557.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266834.SMc02728.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC46969 ; CAC46969 ; SMc02728 .
    GeneIDi 1234057.
    KEGGi sme:SMc02728.
    PATRICi 23634273. VBISinMel96828_3874.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SMEL266834:GJF6-2445-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.

    Entry informationi

    Entry nameiFTHS_RHIME
    AccessioniPrimary (citable) accession number: Q92N42
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3