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Q92N42 (FTHS_RHIME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:R02390
ORF Names:SMc02728
OrganismRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]
Taxonomic identifier266834 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length559 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Sequence caution

The sequence CAC46969.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 559559Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199372

Regions

Nucleotide binding68 – 758ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92N42 [UniParc].

Last modified December 6, 2005. Version 2.
Checksum: 5B877C0EDBF1FF13

FASTA55960,412
        10         20         30         40         50         60 
MGEVKSDIEI ARAARKQPIM EVGAKLGIPP EHLLPYGHDK AKVSAEFIAA QNEKRNGRLI 

        70         80         90        100        110        120 
LVTAINPTPA GEGKTTTTVG LGDGLNRIGK KAIVCIREAS LGPCFGIKGG AAGGGYAQVV 

       130        140        150        160        170        180 
PMEDINLHFT GDFHAITSAH NLLSALIDNH IYWGNEQAID IRRIAWRRVM DMNDRALRQI 

       190        200        210        220        230        240 
VGSLGGVANG YPRETGFDIT VASEVMAILC LAMDIKDLEK RLGNIIIGYR RDKSPVFARD 

       250        260        270        280        290        300 
IKADGAMAVL LKDAMQPNLV QTLENNPAFV HGGPFANIAH GCNSVVATTT ALKLADYVVT 

       310        320        330        340        350        360 
EAGFGADLGA EKFFDIKCRK AGLTPDAAVI VATVRAIKMN GGVKREDLGR ESVEAVRKGC 

       370        380        390        400        410        420 
ANLGRHIQNV KKFGVPVLVA INHFTSDTEA EVRAIKDYVR TLGSEAVLCK HWAEGSAGIE 

       430        440        450        460        470        480 
ELAYKVVDLA NAGHSQFSPL YPDEMPLFQK IETIAKDIYH ASEVIADKLV REQLRTWEDQ 

       490        500        510        520        530        540 
GYGDLPICMA KTQYSFSTDP NLRGAPTGHA VPIREVRLAA GAGFIVVITG EIMTMPGLPK 

       550 
VPSSERIRLN EQGYIEGLF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591688 Genomic DNA. Translation: CAC46969.1. Different initiation.
RefSeqNP_386496.2. NC_003047.1.

3D structure databases

ProteinModelPortalQ92N42.
SMRQ92N42. Positions 7-557.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266834.SMc02728.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC46969; CAC46969; SMc02728.
GeneID1234057.
KEGGsme:SMc02728.
PATRIC23634273. VBISinMel96828_3874.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

BioCycSMEL266834:GJF6-2445-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_RHIME
AccessionPrimary (citable) accession number: Q92N42
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: April 16, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways