Reviewed, UniProtKB/Swiss-Prot Q92MT4 (XYLD_RHIME)

Names and origin

Protein names

Recommended name:
    Putative D-xylulose reductase
    EC=1.1.1.9
Alternative name(s):
    Xylitol dehydrogenase
      Short name=XDH

Gene names

Ordered Locus Names:	R02526
ORF Names:	SMc01992

Organism

Rhizobium meliloti (Sinorhizobium meliloti) [Complete proteome] [HAMAP]

Taxonomic identifier

382 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Xylitol + NAD+ = D-xylulose + NADH.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	D-xylulose reductase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Putative D-xylulose reductase		PRO_0000160887
Sites
	Metal binding	39	1	Zinc; catalytic By similarity
	Metal binding	64	1	Zinc; catalytic By similarity
	Metal binding	150	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92MT4-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: B569D3D40397B895	FASTA	346	36,463
	10 20 30 40 50 60 MAKALVLEKK GQLSLRDIPV RRDLSPTDVL IGIRTVGVCG SDVHYYTHGK IGPFVVNEPM 70 80 90 100 110 120 ILGHEAAGVV LEVGSQVRHL KKGDRVCMEP GIPDLSSRSS KLGIYNVDPS VRFWATPPVH 130 140 150 160 170 180 GCLTPEVVHP AAFTYRLPDH VSFAEGAMVE PFAIGVQAAL RAGIRPGDVG AVMGAGPIGM 190 200 210 220 230 240 MTALAALAGG CSKVYVADLA QPKLDVIGAY EGIETINVRQ QAVSEALAGA TGGWGADVVF 250 260 270 280 290 300 ECSGAAPAIL ALPSLARPGG TVVLVGMPVE PVPFDIVGMQ AKELRIETVF RYANVYDRAI 310 320 330 340 ELIASGKVDL KPLISATIPF DESIAAFDRA VEARPTDVKI QIEMPA

References

[1]

"Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021." Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D. , Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F. Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001) [PubMed: 11481430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1021.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL591688 Genomic DNA. Translation: CAC47105.1.
RefSeq	NP_386632.1.
3D structure databases
SMR	Q92MT4. Positions 2-345.
ModBase	Search...
Genome annotation databases
GeneID	1234194.
GenomeReviews	Gene locus R02526 in contig AL591688_GR.
KEGG	sme:SMc01992.
NMPDR	fig|266834.1.peg.3820.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG753318.
OMA	QFTEEMG.
Enzyme and pathway databases
BioCyc	SMEL266834:SMC01992-MONOMER.
BRENDA	1.1.1.9. 142.
Family and domain databases
InterPro	IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn. IPR013149. ADH_Zn-bd. IPR002328. ADH_Zn_CS. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLD_RHIME

Accession

Primary (citable) accession number: Q92MT4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
Last sequence update:	December 1, 2001
Last modified:	January 19, 2010
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)