Q92MT4 (XYLD_RHIME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative D-xylulose reductase
EC=1.1.1.9

Alternative name(s):
Xylitol dehydrogenase
Short name=XDH

Gene names

Ordered Locus Names:	R02526
ORF Names:	SMc01992

Organism

Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]

Taxonomic identifier

266834 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Xylitol + NAD+ = D-xylulose + NADH.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	D-xylulose reductase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Putative D-xylulose reductase		PRO_0000160887
Sites
	Metal binding	39	1	Zinc; catalytic By similarity
	Metal binding	64	1	Zinc; catalytic By similarity
	Metal binding	150	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92MT4 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: B569D3D40397B895	FASTA	346	36,463
	10 20 30 40 50 60 MAKALVLEKK GQLSLRDIPV RRDLSPTDVL IGIRTVGVCG SDVHYYTHGK IGPFVVNEPM 70 80 90 100 110 120 ILGHEAAGVV LEVGSQVRHL KKGDRVCMEP GIPDLSSRSS KLGIYNVDPS VRFWATPPVH 130 140 150 160 170 180 GCLTPEVVHP AAFTYRLPDH VSFAEGAMVE PFAIGVQAAL RAGIRPGDVG AVMGAGPIGM 190 200 210 220 230 240 MTALAALAGG CSKVYVADLA QPKLDVIGAY EGIETINVRQ QAVSEALAGA TGGWGADVVF 250 260 270 280 290 300 ECSGAAPAIL ALPSLARPGG TVVLVGMPVE PVPFDIVGMQ AKELRIETVF RYANVYDRAI 310 320 330 340 ELIASGKVDL KPLISATIPF DESIAAFDRA VEARPTDVKI QIEMPA

References

[1]	"Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021." Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D. , Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F. Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001) [PubMed: 11481430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1021.
[2]	"The composite genome of the legume symbiont Sinorhizobium meliloti." Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F., Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G., Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P., Cowie A. , Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S., Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I., Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S., Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C., Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R., Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H., Wong K., Yeh K.-C., Batut J. Science 293:668-672(2001) [PubMed: 11474104] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1021.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL591688 Genomic DNA. Translation: CAC47105.1.
RefSeq	NP_386632.1. NC_003047.1.
3D structure databases
ProteinModelPortal	Q92MT4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1234194.
GenomeReviews	Gene locus R02526 in contig AL591688_GR.
KEGG	sme:SMc01992.
NMPDR	fig|266834.1.peg.3820.
PATRIC	23634565. VBISinMel96828_4020.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG753318.
OMA	KCLGATD.
ProtClustDB	CLSK864144.
Enzyme and pathway databases
BioCyc	SMEL266834:SMC01992-MONOMER.
Family and domain databases
InterPro	IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn-type. IPR002328. ADH_Zn_CS. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K05351.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
SUPFAM	SSF50129. GroES_like. 1 hit.
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLD_RHIME

Accession

Primary (citable) accession number: Q92MT4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program