Q92MQ8 (G6PI1_RHIME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative glucose-6-phosphate isomerase 1
Short name=GPI 1
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase 1
Short name=PGI 1
Phosphohexose isomerase 1
Short name=PHI 1

Gene names

Name:	pgiA1
Ordered Locus Names:	R02554
ORF Names:	SMc02042

Organism

Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]

Taxonomic identifier

266834 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	214 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_01410
Cofactor	Binds 1 iron ion per subunit By similarity. HAMAP MF_01410
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_01410
Subunit structure	Homodimer By similarity. HAMAP MF_01410
Subcellular location	Cytoplasm By similarity HAMAP MF_01410.
Miscellaneous	R.meliloti has a classic glucose-6-phosphate isomerase (AC Q92SC4) and two archaeal-type glucose-6-phosphate isomerases. HAMAP MF_01410
Sequence similarities	Belongs to the archaeal-type GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 214	214	Putative glucose-6-phosphate isomerase 1 HAMAP MF_01410		PRO_0000185361
Sites
	Metal binding	92	1	Iron By similarity
	Metal binding	94	1	Iron By similarity
	Metal binding	101	1	Iron By similarity
	Metal binding	140	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92MQ8 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 062127EC48458BBF	FASTA	214	24,049
	10 20 30 40 50 60 MTKLFEPAGC RVDLRTGAMS DATGAYQKRF RDLAGLYADE AAFSAMQETW NDTVVYEVSE 70 80 90 100 110 120 FRPNERTGDL IFGVTRMLPG KVGEEYFVTR GHIHKQSDRP EIYYGQKGRG LMLLESPEGE 130 140 150 160 170 180 VRVVAVDAQT VCYVPPYWIH RSVNIGGDEL VMLFCYPADS GQDYDCIAKA GGMRARIIDD 190 200 210 GRGGWKQIDN PNWRMRDAAT VAALYGREKK EENA

References

[1]

"Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021." Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D. , Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F. Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001) [PubMed: 11481430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1021.

[2]

"The composite genome of the legume symbiont Sinorhizobium meliloti." Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F., Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G., Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P., Cowie A. , Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S., Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I., Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S., Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C., Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R., Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H., Wong K., Yeh K.-C., Batut J. Science 293:668-672(2001) [PubMed: 11474104] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1021.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL591688 Genomic DNA. Translation: CAC47133.1.
RefSeq	NP_386660.1. NC_003047.1.
3D structure databases
ProteinModelPortal	Q92MQ8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1234222.
GenomeReviews	Gene locus R02554 in contig AL591688_GR.
KEGG	sme:SMc02042.
NMPDR	fig|266834.1.peg.3848.
PATRIC	23634625. VBISinMel96828_4050.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG725476.
OMA	YPADAGH.
ProtClustDB	PRK04190.
Enzyme and pathway databases
BioCyc	SMEL266834:SMC02042-MONOMER.
Family and domain databases
HAMAP	MF_01410. G6P_isomerase_arch. [Tree]
InterPro	IPR011051. Cupin_RmlC_type. IPR010551. G6P_isomerase_prok. IPR016758. G6P_isomerase_subgr. IPR014710. RmlC-like_jellyroll. [Graphical view]
Gene3D	G3DSA:2.60.120.10. RmlC-like_jellyroll. 1 hit.
KO	K06859.
Pfam	PF06560. GPI. 1 hit. [Graphical view]
PIRSF	PIRSF019325. Glucose-6-phosphate_isomerase. 1 hit.
SUPFAM	SSF51182. RmlC_like_cupin. 1 hit.
ProtoNet	Search...

Entry information

Entry name

G6PI1_RHIME

Accession

Primary (citable) accession number: Q92MQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program