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Protein

Putative glucose-6-phosphate isomerase 1

Gene

pgiA1

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Pathway: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Putative glucose-6-phosphate isomerase 2 (pgiA2), Putative glucose-6-phosphate isomerase 1 (pgiA1), Glucose-6-phosphate isomerase (pgi)
  3. Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (pfp)
  4. Fructose-bisphosphate aldolase (fbaB), Fructose-bisphosphate aldolase (cbbA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi92 – 921IronBy similarity
Metal bindingi94 – 941IronBy similarity
Metal bindingi101 – 1011IronBy similarity
Metal bindingi140 – 1401IronBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-2611-MONOMER.
SABIO-RKQ92MQ8.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glucose-6-phosphate isomerase 1 (EC:5.3.1.9)
Short name:
GPI 1
Alternative name(s):
Phosphoglucose isomerase 1
Short name:
PGI 1
Phosphohexose isomerase 1
Short name:
PHI 1
Gene namesi
Name:pgiA1
Ordered Locus Names:R02554
ORF Names:SMc02042
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Putative glucose-6-phosphate isomerase 1PRO_0000185361Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi266834.SMc02042.

Structurei

3D structure databases

ProteinModelPortaliQ92MQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal-type GPI family.Curated

Phylogenomic databases

eggNOGiCOG2140.
HOGENOMiHOG000243903.
KOiK06859.
OMAiYPADAGH.
OrthoDBiEOG6M6JRR.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_01410. G6P_isomerase_arch.
InterProiIPR016758. G6P_isomerase_archaea/bacteria.
IPR010551. G6P_isomerase_prok.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF06560. GPI. 1 hit.
[Graphical view]
PIRSFiPIRSF019325. Glucose-6-phosphate_isomerase. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92MQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKLFEPAGC RVDLRTGAMS DATGAYQKRF RDLAGLYADE AAFSAMQETW
60 70 80 90 100
NDTVVYEVSE FRPNERTGDL IFGVTRMLPG KVGEEYFVTR GHIHKQSDRP
110 120 130 140 150
EIYYGQKGRG LMLLESPEGE VRVVAVDAQT VCYVPPYWIH RSVNIGGDEL
160 170 180 190 200
VMLFCYPADS GQDYDCIAKA GGMRARIIDD GRGGWKQIDN PNWRMRDAAT
210
VAALYGREKK EENA
Length:214
Mass (Da):24,049
Last modified:December 1, 2001 - v1
Checksum:i062127EC48458BBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA. Translation: CAC47133.1.
RefSeqiNP_386660.1. NC_003047.1.
WP_010970025.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC47133; CAC47133; SMc02042.
GeneIDi1234222.
KEGGisme:SMc02042.
PATRICi23634625. VBISinMel96828_4050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA. Translation: CAC47133.1.
RefSeqiNP_386660.1. NC_003047.1.
WP_010970025.1. NC_003047.1.

3D structure databases

ProteinModelPortaliQ92MQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266834.SMc02042.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC47133; CAC47133; SMc02042.
GeneIDi1234222.
KEGGisme:SMc02042.
PATRICi23634625. VBISinMel96828_4050.

Phylogenomic databases

eggNOGiCOG2140.
HOGENOMiHOG000243903.
KOiK06859.
OMAiYPADAGH.
OrthoDBiEOG6M6JRR.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciSMEL266834:GJF6-2611-MONOMER.
SABIO-RKQ92MQ8.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_01410. G6P_isomerase_arch.
InterProiIPR016758. G6P_isomerase_archaea/bacteria.
IPR010551. G6P_isomerase_prok.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF06560. GPI. 1 hit.
[Graphical view]
PIRSFiPIRSF019325. Glucose-6-phosphate_isomerase. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiG6PI1_RHIME
AccessioniPrimary (citable) accession number: Q92MQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: December 1, 2001
Last modified: May 27, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

R.meliloti has a classic glucose-6-phosphate isomerase (AC Q92SC4) and two archaeal-type glucose-6-phosphate isomerases.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.