Q92MH1 (ARLY1_RHIME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase 1
Short name=ASAL 1
EC=4.3.2.1

Alternative name(s):
Arginosuccinase 1

Gene names

Name:	argH1
Ordered Locus Names:	R02647
ORF Names:	SMc00725

Organism

Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]

Taxonomic identifier

266834 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 467	467	Argininosuccinate lyase 1 HAMAP MF_00006		PRO_0000137812

Sequences

	Sequence		Length	Mass (Da)
	Q92MH1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 2493791132C7602B	FASTA	467	50,815
	10 20 30 40 50 60 MADGSSETKS SNQMWGGRFA SGPDAIMEEI NASIGFDKKL YAQDIRGSIA HATMLAHQGI 70 80 90 100 110 120 ISAEDKDKIV HGLDTILSEI DSGAFEFSRR LEDIHMNIEA RLAALIGPAA GRLHTARSRN 130 140 150 160 170 180 DQVALDFRLW VKEELQKTEK ALTGLIAAFL DRAEEHAETV MPGFTHLQTA QPVTFGHHCM 190 200 210 220 230 240 AYVEMFGRDR ARVRHAIEHM DESPIGAAAL AGTGFPIDRH MTAKALGFRE PTRNSIDTVS 250 260 270 280 290 300 DRDFALEFLS IAAIAATHLS RLAEEIVIWS TPQFGFIRLS DAFSTGSSIM PQKKNPDAAE 310 320 330 340 350 360 LVRAKTGRVN GSLVALLTVM KGLPLAYSKD MQEDKEQVFD AAESLELAIA AMTGMIRDVT 370 380 390 400 410 420 IRADRMKAAA GSGYSTATDL ADWLVREAGL PFRDAHHVTG RVVALAEQKG CDLADLPLAE 430 440 450 460 LQAINSAITD KVYGVLTVEA SVASRTSFGG TAPSEVRKQI AWWRARN

References

[1]	"Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021." Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D. , Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F. Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001) [PubMed: 11481430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1021.
[2]	"The composite genome of the legume symbiont Sinorhizobium meliloti." Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F., Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G., Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P., Cowie A. , Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S., Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I., Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S., Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C., Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R., Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H., Wong K., Yeh K.-C., Batut J. Science 293:668-672(2001) [PubMed: 11474104] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1021.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL591688 Genomic DNA. Translation: CAC47226.1.
RefSeq	NP_386753.1. NC_003047.1.
3D structure databases
ProteinModelPortal	Q92MH1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1234322.
GenomeReviews	Gene locus R02647 in contig AL591688_GR.
KEGG	sme:SMc00725.
NMPDR	fig|266834.1.peg.3941.
PATRIC	23634829. VBISinMel96828_4146.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG539632.
OMA	MAEDLIF.
ProtClustDB	PRK00855.
Enzyme and pathway databases
BioCyc	SMEL266834:SMC00725-MONOMER.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY1_RHIME

Accession

Primary (citable) accession number: Q92MH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program