ID   Q92M76_RHIME            Unreviewed;       634 AA.
AC   Q92M76;
DT   01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT   01-DEC-2001, sequence version 1.
DT   27-MAR-2024, entry version 111.
DE   SubName: Full=Probable adenylate/guanylate cyclase {ECO:0000313|EMBL:CAC47348.1};
DE            EC=4.6.1.1 {ECO:0000313|EMBL:CAC47348.1};
GN   Name=cyaF2 {ECO:0000313|EMBL:CAC47348.1};
GN   ORFNames=SMc03985 {ECO:0000313|EMBL:CAC47348.1};
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834 {ECO:0000313|EMBL:CAC47348.1, ECO:0000313|Proteomes:UP000001976};
RN   [1] {ECO:0000313|EMBL:CAC47348.1, ECO:0000313|Proteomes:UP000001976}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021 {ECO:0000313|EMBL:CAC47348.1,
RC   ECO:0000313|Proteomes:UP000001976};
RX   PubMed=11481430; DOI=10.1073/pnas.161294398;
RA   Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA   Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA   Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA   Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA   Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT   "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT   meliloti strain 1021.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN   [2] {ECO:0000313|Proteomes:UP000001976}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021 {ECO:0000313|Proteomes:UP000001976};
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
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DR   EMBL; AL591688; CAC47348.1; -; Genomic_DNA.
DR   RefSeq; NP_386875.1; NC_003047.1.
DR   RefSeq; WP_010970181.1; NC_003047.1.
DR   AlphaFoldDB; Q92M76; -.
DR   EnsemblBacteria; CAC47348; CAC47348; SMc03985.
DR   GeneID; 61604231; -.
DR   KEGG; sme:SMc03985; -.
DR   PATRIC; fig|266834.11.peg.4279; -.
DR   eggNOG; COG0457; Bacteria.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG5616; Bacteria.
DR   HOGENOM; CLU_019981_0_0_5; -.
DR   OrthoDB; 9807521at2; -.
DR   Proteomes; UP000001976; Chromosome.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   Gene3D; 3.40.50.10070; TolB, N-terminal domain; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR44858; TETRATRICOPEPTIDE REPEAT PROTEIN 6; 1.
DR   PANTHER; PTHR44858:SF1; UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF14559; TPR_19; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50005; TPR; 2.
PE   4: Predicted;
KW   Lyase {ECO:0000313|EMBL:CAC47348.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001976};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   DOMAIN          18..133
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REPEAT          423..456
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          457..490
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   634 AA;  70440 MW;  C664D939E2DFEA6F CRC64;
     MLGHKMKIEA LLERRLTAIL AADVVGYSRL MGADEAGTLA ALKRHRRELL EPRIADHKGR
     IVKLAGDSML VEFSSVVNAV ACAAAIQRGM LAANEGLPKS RRIELRIGIH LGDVIVEDGD
     IFGDGVNVAA RLEGLADPSG IAVSASVRDH VGSRLDVGFI DKGEYSLKNI ASTVRVYTVS
     LGDNSLGKRA ESSGVVDRGY ELSIAVLPFT NMSHDPEQEY FSDGITEDVI TDLSKISRLH
     VVARNTVFTY KGKSVKVKQI AHELGVRFIL EGSVRKAGGR VRITGQLIDA QTGGHLWADR
     YDRDLTDIFA IQDEITHAIV DQLKIKLLPE EKRAIESDPT TSVEAYTYYL RGRQFSHTWT
     RPYLLLARRM FLKAVELDPN YARAYAGIAE CECAIRDWHE KEFPLESILD MSARALALDP
     NLAEAHASRG LALNHDGQTE EASREFLQAL ALDPSLYEAN LYYGRFLFAQ GRFREAIGFF
     ERAAEIRSDD YFSPIHLMGC YLSLGMETER QRWARIGIER AQSAMERNPE NASPAHRGAL
     ALAHMGEAER AKEWVSRALA IDPDDIVAQY NAACVHSLLG EGERALELLE TVVPQSSSYH
     VQWFNQDPDL DLIRDDPRFR ALLDALAECK GGRR
//