ID   Q92LP1_RHIME            Unreviewed;       590 AA.
AC   Q92LP1;
DT   01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT   01-DEC-2001, sequence version 1.
DT   27-MAR-2024, entry version 109.
DE   SubName: Full=Adenylate cyclase {ECO:0000313|EMBL:CAC47573.1};
DE            EC=4.6.1.1 {ECO:0000313|EMBL:CAC47573.1};
GN   Name=cyaF1 {ECO:0000313|EMBL:CAC47573.1};
GN   ORFNames=SMc03099 {ECO:0000313|EMBL:CAC47573.1};
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834 {ECO:0000313|EMBL:CAC47573.1, ECO:0000313|Proteomes:UP000001976};
RN   [1] {ECO:0000313|EMBL:CAC47573.1, ECO:0000313|Proteomes:UP000001976}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021 {ECO:0000313|EMBL:CAC47573.1,
RC   ECO:0000313|Proteomes:UP000001976};
RX   PubMed=11481430; DOI=10.1073/pnas.161294398;
RA   Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA   Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA   Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA   Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA   Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT   "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT   meliloti strain 1021.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN   [2] {ECO:0000313|Proteomes:UP000001976}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021 {ECO:0000313|Proteomes:UP000001976};
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
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DR   EMBL; AL591688; CAC47573.1; -; Genomic_DNA.
DR   RefSeq; NP_387100.1; NC_003047.1.
DR   RefSeq; WP_010970341.1; NC_003047.1.
DR   AlphaFoldDB; Q92LP1; -.
DR   EnsemblBacteria; CAC47573; CAC47573; SMc03099.
DR   GeneID; 61604460; -.
DR   KEGG; sme:SMc03099; -.
DR   PATRIC; fig|266834.11.peg.4523; -.
DR   eggNOG; COG0457; Bacteria.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG5616; Bacteria.
DR   HOGENOM; CLU_019981_0_0_5; -.
DR   OrthoDB; 9807521at2; -.
DR   Proteomes; UP000001976; Chromosome.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   Gene3D; 3.40.50.10070; TolB, N-terminal domain; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF52964; TolB, N-terminal domain; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000313|EMBL:CAC47573.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001976}.
FT   DOMAIN          7..122
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   590 AA;  65039 MW;  B8294E36ECE60AE1 CRC64;
     MEQRLAAVLA ADMAGYSRLM EADEAGTVAR LRTHRIELID PAIAKNKGHL IKTTGDGMLV
     EFQSVTDAVK CAVEIQSRMK RRNADVAQDR RIEFRIGINL GDIIFDEDDI FGDGVNIAAR
     IEQLADVGGI CVTAAVATQV ADRIDVPIED LGEKMLKNIS RPIHLFRVGI EGPVLPPFPE
     ATDAPRAISK PSIVVLPFDN MSGDPDQEFF ADGLTEDIIT ELSRRHELFV ISRNSSFVYK
     NQPVNVREVA EKLGAQYLVE GSVRKIGDRV RVTVQLIDAV NDAHIWADKY DRRLDDIFAI
     QDEVTAAIAA TLPGRVEAAQ RDLLARTKPA NMAAYECALA AKVLHHRSTV ADNEQAQALI
     DRAVALDPGY AHAHAWRACI LGQAWVHGWC EDKDAVWAEI VAELDRALAL DDNDADVHRI
     LAAVNVNNNA LTTARYHQER ALSLNPNYDL VVVQQGELLT WLGRPEEGVE WIRKAMQLNP
     HHPERFWSHL GKAHFAARQY GEAIEAFMHL SVLDHVQHAF VAACYGWLGD DIAAHAHMEK
     VRTLAPDFDL DAFLATQHYV QESDLQHLSE GLVKAGAKGG SAAANGIAAQ
//