Reviewed, UniProtKB/Swiss-Prot Q92LI5 (MSRA2_RHIME)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrA 2
      Short name=Protein-methionine-S-oxide reductase 2
    EC=1.8.4.11
Alternative name(s):
    Peptide-methionine (S)-S-oxide reductase 2
      Short name=Peptide Met(O) reductase 2

Gene names

Name:	msrA2
Ordered Locus Names:	R03068
ORF Names:	SMc02467

Organism

Rhizobium meliloti (Sinorhizobium meliloti) [Complete proteome] [HAMAP]

Taxonomic identifier

382 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity.
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin. L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin.
Sequence similarities	Belongs to the msrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	Peptide methionine sulfoxide reductase msrA 2		PRO_0000138574
Sites
	Active site	32	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92LI5-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 54391D83491C8F0F	FASTA	198	22,136
	10 20 30 40 50 60 MLRLLFGFLV TCFLLLPARA AEPQYAIFAG GCFWCVESDF DAVPGVLETI SGYAGGKSAN 70 80 90 100 110 120 PTYEDYAKGG HREVVRVKFD PDRVSYAELV GVLFRTTDPT DGDGQFCDRG FAYTTAIHAL 130 140 150 160 170 180 NERQAMDAKA EKIKAEAELG RPIVTPVEGA AKFWPAEDYH QDFGKRNPIR YWYYRNGCGR 190 NRTVEKLWGD RAYAGVSH

References

[1]

"Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021." Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D. , Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F. Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001) [PubMed: 11481430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1021.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL591688 Genomic DNA. Translation: CAC47647.1.
RefSeq	NP_387174.1.
3D structure databases
HSSP	HSSP built from PDB template 1NWA based on UniProtKB P96814.
ModBase	Search...
Genome annotation databases
GeneID	1234752.
GenomeReviews	Gene locus R03068 in contig AL591688_GR.
KEGG	sme:SMc02467.
NMPDR	fig|266834.1.peg.4362.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q92LI5.
Enzyme and pathway databases
BioCyc	SMEL266834:SMC02467-MON.
Family and domain databases
HAMAP	MF_01401. [Tree]
InterPro	IPR002569. MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
ProDom	PD003489. PMSR. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00401. msrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA2_RHIME

Accession

Primary (citable) accession number: Q92LI5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	December 1, 2001
Last modified:	November 4, 2008
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)