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Q92LB2 (PROA_RHIME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-glutamyl phosphate reductase
Short name=GPR
EC=1.2.1.41
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase
Glutamyl-gamma-semialdehyde dehydrogenase
Short name=GSA dehydrogenase
Gene names
Name:proA
Ordered Locus Names:R03161
ORF Names:SMc03777
OrganismRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]
Taxonomic identifier266834 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. HAMAP MF_00412

Catalytic activity

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412

Subcellular location

Cytoplasm By similarity HAMAP MF_00412.

Sequence similarities

Belongs to the gamma-glutamyl phosphate reductase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Proline biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproline biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

glutamate-5-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 427427Gamma-glutamyl phosphate reductase HAMAP MF_00412
PRO_0000189772

Sequences

Sequence LengthMass (Da)Tools
Q92LB2 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 69FB7EBB48545821

FASTA42745,207
        10         20         30         40         50         60 
MLETVEKDKD VNAMMLEIGR RAKAAARPLA TASAERKHAA LVAMAGVIVT RTAEILAANA 

        70         80         90        100        110        120 
LDLENARESG VASAFIDRLT LTESRIRDMA DGIRAIAELI DPVGEVISEW DRPNGLHIER 

       130        140        150        160        170        180 
VRTPLGVIGV IYESRPNVTA DAGALCLKAG NAVILRGGSD SFHSSRAIHA CLTEGLKVAG 

       190        200        210        220        230        240 
LPEDAIQMVP VADRAAVGAM LTGLNGAIDV IVPRGGKSLV ARVQNEARVP VFAHLEGLCH 

       250        260        270        280        290        300 
IYVDASADRD MAKKIVVNAK MRRTGICGAA ETLLIDRNAA EKFAKPLLEA LVDAGCEVRA 

       310        320        330        340        350        360 
SDDLASVMPG LKAATDEDWA TEYLDAIISA RLVDGISGAI EHINTWSSAH TEAVIAEDPA 

       370        380        390        400        410        420 
VVERFFSEID SAILLHNAST QFADGGEFGM GGEIGIATGK MHARGPVGVE QLTSFKYRVR 


GTGQVRP

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL591688 Genomic DNA. Translation: CAC47740.1.
RefSeqNP_387267.1. NC_003047.1.

3D structure databases

ProteinModelPortalQ92LB2.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1234854.
GenomeReviewsGene locus R03161 in contig AL591688_GR.
KEGGsme:SMc03777.
NMPDRfig|266834.1.peg.4455.
PATRIC23635972. VBISinMel96828_4709.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG318080.
OMAYGICGAM.
ProtClustDBPRK00197.

Enzyme and pathway databases

BioCycSMEL266834:SMC03777-MONOMER.

Family and domain databases

HAMAPMF_00412. ProA.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
KOK00147.
PANTHERPTHR11063:SF1. GSA_DH. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFPIRSF000151. GPR. 1 hit.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00407. ProA. 1 hit.
PROSITEPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePROA_RHIME
AccessionPrimary (citable) accession number: Q92LB2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: December 1, 2001
Last modified: January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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