ID   DNE21_RHIME             Reviewed;        1116 AA.
AC   Q92LA6;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   16-JUN-2009, entry version 46.
DE   RecName: Full=Error-prone DNA polymerase 1;
DE            EC=2.7.7.7;
GN   Name=dnaE2-1; OrderedLocusNames=R03171; ORFNames=SMc03788;
OS   Rhizobium meliloti (Sinorhizobium meliloti).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=382;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   MEDLINE=21396507; PubMed=11481430; DOI=10.1073/pnas.161294398;
RA   Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA   Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA   Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D.,
RA   Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U.,
RA   Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT   "Analysis of the chromosome sequence of the legume symbiont
RT   Sinorhizobium meliloti strain 1021.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis
CC       and translesion synthesis (TLS). It is not the major replicative
CC       DNA polymerase (By similarity).
CC   -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
CC       diphosphate + DNA(n+1).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily.
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DR   EMBL; AL591688; CAC47750.1; -; Genomic_DNA.
DR   RefSeq; NP_387277.1; -.
DR   GeneID; 1234864; -.
DR   GenomeReviews; AL591688_GR; R03171.
DR   KEGG; sme:SMc03788; -.
DR   NMPDR; fig|266834.1.peg.4465; -.
DR   HOGENOM; Q92LA6; -.
DR   OMA; Q92LA6; TIFATIE.
DR   BioCyc; SMEL266834:SMC03788-MON; -.
DR   BRENDA; 2.7.7.7; 142.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:HAMAP.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0045020; P:error-prone DNA repair; IEA:HAMAP.
DR   HAMAP; MF_01902; -; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha.
DR   InterPro; IPR004365; NA_bd_OB_tRNA-helicase.
DR   InterPro; IPR004013; PHP_C.
DR   InterPro; IPR003141; PHP_N.
DR   InterPro; IPR004805; PolC_alpha.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.
FT   CHAIN         1   1116       Error-prone DNA polymerase 1.
FT                                /FTId=PRO_0000103395.
SQ   SEQUENCE   1116 AA;  124842 MW;  C8D6339601CEB405 CRC64;
     MSADAVFCEL GARTNFSFLE GAAPAEEMVV FAKKAGLAGL GIADRNSVAG VVRAHAKAKV
     EGYPFQPGAR LVFADGTPDI LAYPKNRRGW GHLCRLLSAG NLRSKKGDCT LHLADLLEWQ
     EELLLIVMQG EGRPEPESLE VLLGTLKEHA GNRLYLGLAP HYDGFDRHDF AVLAAIARKA
     GIGLLATNDA LYHDPHYRPL ADVVTSIREH VPIAGAGFLL QKNAERHLKG PREMARLFSD
     YPEAIANTRK FFRELAFSLD ELSHQYPDEN ADGETPAESL RRLVAEGAAE RYPEGVPEKV
     MRQIDYELEL IHDKKYEPYF LTVHKLVKFA RSVNILCQGR GSAANSSVCF CLGITDVDPQ
     KFTLLFDRFL SKDRDEPPDI DVDFEHERRE EVIQYIYRTY GKEHAGLTAA VISYRSRSAG
     REVAKAFGLS EDVQSALVSS IWGWGTSPFT EEQAKGAGLD AADPLTRRVL AYASLLMNFP
     RHLSQHVGGF VITRDRLDEV VPIMNTAMPD RYMIEWDKDD LDELKILKVD VLALGMLTCL
     AKGFKLLEAH YGEPITLAEI YQDHRDAVYD MICRADTVGV FQIESRAQMS MLPRLQPREM
     YDLVIEVAIV RPGPIQGNMV HPYLKRREAQ RRGEAVVYPS PELKAVLERT LGVPLFQEQA
     MQIAITAAGF SPSEADRLRR AMATFKRTGT IHTFERKMVE GMVANDYERE FAERCFNQIK
     GFGEYGFPES HAASFASLVY ASAWLKTYYP DIFCAALLNA QPMGFYAPAQ LVRDAREHGV
     RMLPVDINHS DWDALLEGEG AFDKNAVHPR HASMREVIKT RKAVRLGFRL VKGLKQTDMK
     ALVARRGEGY RSVHDLWLRS GLSRSVLERL ADADAFRSIG LDRRAALWAV KALDEQSAVE
     RLPLFEGAGS DDLQIEPKVA LPDMPAGEQV IHDYRTLTLS LKAHPVSFMR EDFSRRGILR
     SRDLAATATG RWVTVAGLVL VRQRPGSANG VIFMTIEDET GIANIIVWEK TFQKYRRQVM
     GSRLVKVRGR LQNQSGVIHV VADHLEDITP MLGLLRREAR RFGVNDRADG ALRPSADARE
     KKKLRQLRLG LPARAAPEGE AAAQVAEVMP KGRNFH
//