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Protein

DNA translocase FtsK

Gene

ftsK

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi534 – 5396ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-3281-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA translocase FtsK
Gene namesi
Name:ftsK
Ordered Locus Names:R03191
ORF Names:SMc03808
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621HelicalSequence analysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence analysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence analysisAdd
BLAST
Transmembranei169 – 18921HelicalSequence analysisAdd
BLAST
Topological domaini190 – 881692CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 881881DNA translocase FtsKPRO_0000098285Add
BLAST

Interactioni

Subunit structurei

Homohexamer. Forms a ring that surrounds DNA (By similarity).By similarity

Protein-protein interaction databases

STRINGi266834.SMc03808.

Structurei

3D structure databases

ProteinModelPortaliQ92L89.
SMRiQ92L89. Positions 379-792.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini514 – 733220FtsKPROSITE-ProRule annotationAdd
BLAST

Domaini

Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase (By similarity).By similarity

Sequence similaritiesi

Belongs to the FtsK/SpoIIIE/SftA family.Curated
Contains 1 FtsK domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1674. LUCA.
HOGENOMiHOG000010003.
KOiK03466.
OMAiQECRLIM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR025199. FtsK_4TM.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF13491. FtsK_4TM. 1 hit.
PF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50901. FTSK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92L89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSNTATLD SRSNRFVLTH FVWRQIASLA GFVLVGALAL AIAALSTWNV
60 70 80 90 100
ADPSFSYATS NEPTNLLGYG GAVFADIFMQ FFGLASVVAL LPAVAWALVL
110 120 130 140 150
IRGTHFDKVL KRLGLWFAGS VLASAALSCV PAPITWPLPN GLGGVFGDMI
160 170 180 190 200
LRFPALFTGT FPTGTFATVL ACLFTAPAAW CLVYSAGLIG VSEDEEAEPA
210 220 230 240 250
PEPAPSKART IRDELEEEDE EGPLTVLMGS LAHMRYTAQA RLRRAFGMGA
260 270 280 290 300
KPAKRQYDEP YDFNNDEFGT LNEPVRPKAQ AGRIEPSLDR SERRIVTPPP
310 320 330 340 350
IMGDEDDPPF DIDERRPAGI LPDDDEDDVA ADWAPRPAPP KPALAMAGSR
360 370 380 390 400
VAPPRPKAGQ RVEREAQRSF VDEDGDFTLP PIHFLAEPKN VARDASLSAD
410 420 430 440 450
ALEQNARMLE GVLEDFGVKG EIIHVRPGPV VTLYELEPAP GIKSSRVIGL
460 470 480 490 500
ADDIARSMSA IAARVAVVPG RNAIGIELPN QRREMVYLRE LIGSRDFETT
510 520 530 540 550
KTKLAMALGK TIGGESVVAD LAKMPHLLVA GTTGSGKSVA INTMILSLLY
560 570 580 590 600
RLRPDQCRLI MIDPKMLELS VYDGIPHLLS PVVTDPKKAV VALKWTVREM
610 620 630 640 650
EERYKKMSKI GVRNIDGFNS RVEQALAKGE AITRTVQTGF DRQTGEAVYE
660 670 680 690 700
TEEFDLSPMP YIVVIIDEMA DLMMVAGKDI EGAVQRLAQM ARAAGIHVIM
710 720 730 740 750
ATQRPSVDVI TGTIKANFPT RISFQVTSKI DSRTILGEQG AEQLLGMGDM
760 770 780 790 800
LYMAGGGRIQ RVHGPFVSDT EVEEVVAYLK TQGVPQYLDA ITEDDEDEND
810 820 830 840 850
GGGPAGTSNL ADSEDPYDQA VAIVLRDGKA STSYVQRRLG IGYNRAASLI
860 870 880
ERMEQEGIIS PANHAGKREI LVPTEAEITG R
Length:881
Mass (Da):95,549
Last modified:December 1, 2001 - v1
Checksum:i28E890501D72585F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA. Translation: CAC47770.1.
RefSeqiNP_387297.1. NC_003047.1.
WP_010970484.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC47770; CAC47770; SMc03808.
GeneIDi1234885.
KEGGisme:SMc03808.
PATRICi23636038. VBISinMel96828_4741.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA. Translation: CAC47770.1.
RefSeqiNP_387297.1. NC_003047.1.
WP_010970484.1. NC_003047.1.

3D structure databases

ProteinModelPortaliQ92L89.
SMRiQ92L89. Positions 379-792.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266834.SMc03808.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC47770; CAC47770; SMc03808.
GeneIDi1234885.
KEGGisme:SMc03808.
PATRICi23636038. VBISinMel96828_4741.

Phylogenomic databases

eggNOGiCOG1674. LUCA.
HOGENOMiHOG000010003.
KOiK03466.
OMAiQECRLIM.

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-3281-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR025199. FtsK_4TM.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF13491. FtsK_4TM. 1 hit.
PF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50901. FTSK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTSK_RHIME
AccessioniPrimary (citable) accession number: Q92L89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.