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Q92L46

- DAPF_RHIME

UniProt

Q92L46 - DAPF_RHIME

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Protein
Diaminopimelate epimerase
Gene
dapF, R03239, SMc03856
Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151Substrate By similarity
Binding sitei47 – 471Substrate By similarity
Binding sitei67 – 671Substrate By similarity
Active sitei76 – 761Proton donor/acceptor By similarity
Binding sitei163 – 1631Substrate By similarity
Sitei165 – 1651Important for catalytic activity By similarity
Binding sitei197 – 1971Substrate By similarity
Sitei215 – 2151Important for catalytic activity By similarity
Active sitei224 – 2241Proton donor/acceptor By similarity

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-3330-MONOMER.
UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimerase (EC:5.1.1.7)
Short name:
DAP epimerase
Gene namesi
Name:dapF
Ordered Locus Names:R03239
ORF Names:SMc03856
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Diaminopimelate epimeraseUniRule annotation
PRO_0000149865Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi76 ↔ 224UniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc03856.

Structurei

3D structure databases

ProteinModelPortaliQ92L46.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni12 – 132Substrate binding By similarity
Regioni76 – 783Substrate binding By similarity
Regioni215 – 2162Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0253.
HOGENOMiHOG000220466.
KOiK01778.
OrthoDBiEOG6ND0M5.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92L46-1 [UniParc]FASTAAdd to Basket

« Hide

MGDQVQFARM NGLGNKILVV DMRGRKDRVT PQAAIALNAD PATEFDQIMA    50
IHDPKSAGTD AWIDIVNSDG SMAQACGNGT RCVVQALAAE TGRKAFLFHT 100
VAGLLEAKEH DNGTISVDMG KPRFGWDQIP LAEEFHDTRR IELQIGPIDA 150
PVLHSPSVAS MGNPHAIFWV ENDVWSYELD RFGPLLENHP IFPERANISI 200
ARIRSRQEMD LRTWERGAGL TLACGSAACA AAVNGARTGR TERMVTVNVP 250
GGPLKIEWRE RDDHVIMTGP AEWEWSGTVD PVTGIFARNE PESGDNGARA 300
L 301
Length:301
Mass (Da):32,859
Last modified:June 6, 2002 - v2
Checksum:i10FA2308A713FFD8
GO

Sequence cautioni

The sequence CAC47818.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591688 Genomic DNA. Translation: CAC47818.1. Different initiation.
RefSeqiNP_387345.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC47818; CAC47818; SMc03856.
GeneIDi1234933.
KEGGisme:SMc03856.
PATRICi23636140. VBISinMel96828_4792.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591688 Genomic DNA. Translation: CAC47818.1 . Different initiation.
RefSeqi NP_387345.1. NC_003047.1.

3D structure databases

ProteinModelPortali Q92L46.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SMc03856.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC47818 ; CAC47818 ; SMc03856 .
GeneIDi 1234933.
KEGGi sme:SMc03856.
PATRICi 23636140. VBISinMel96828_4792.

Phylogenomic databases

eggNOGi COG0253.
HOGENOMi HOG000220466.
KOi K01778.
OrthoDBi EOG6ND0M5.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .
BioCyci SMEL266834:GJF6-3330-MONOMER.

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiDAPF_RHIME
AccessioniPrimary (citable) accession number: Q92L46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 6, 2002
Last modified: June 11, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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