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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Multifunctional enzyme, Transferase
Biological processPurine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133
UPA00074; UER00135

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:R03322
ORF Names:SMc04088
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001921171 – 536Bifunctional purine biosynthesis protein PurHAdd BLAST536

Proteomic databases

PRIDEiQ92KX6

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc04088

Structurei

3D structure databases

ProteinModelPortaliQ92KX6
SMRiQ92KX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 158MGS-likePROSITE-ProRule annotationAdd BLAST151

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DC1 Bacteria
COG0138 LUCA
HOGENOMiHOG000230373
KOiK00602
OMAiDLLFAWK

Family and domain databases

Gene3Di3.40.140.20, 2 hits
3.40.50.1380, 1 hit
HAMAPiMF_00139 PurH, 1 hit
InterProiView protein in InterPro
IPR024051 AICAR_Tfase_dup_dom_sf
IPR016193 Cytidine_deaminase-like
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
IPR002695 PurH-like
PANTHERiPTHR11692 PTHR11692, 1 hit
PfamiView protein in Pfam
PF01808 AICARFT_IMPCHas, 1 hit
PF02142 MGS, 1 hit
PIRSFiPIRSF000414 AICARFT_IMPCHas, 1 hit
SMARTiView protein in SMART
SM00798 AICARFT_IMPCHas, 1 hit
SM00851 MGS, 1 hit
SUPFAMiSSF52335 SSF52335, 1 hit
SSF53927 SSF53927, 1 hit
TIGRFAMsiTIGR00355 purH, 1 hit
PROSITEiView protein in PROSITE
PS51855 MGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q92KX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVASKKIPA PDEVRIKTAL LSVSDKTGIV ELARALNDKG IRLISTGGTH
60 70 80 90 100
KALADAGLPV SDVSELTGFP EIMDGRVKTL HPGVHGGLLA IRDDAEHADA
110 120 130 140 150
MSAHGITAID LAVINLYPFE EVRAKGGDYP TTVENIDIGG PAMIRASAKN
160 170 180 190 200
HAYVTIVTDP ADYSPLLEEI ADGATRYAFR QKMAAKAYAR TAAYDATISN
210 220 230 240 250
WFAEVLDTPM PRHRVLGGLL REEMRYGENP HQKAGFYVTG EKRPGVATAA
260 270 280 290 300
LLQGKQLSYN NINDTDAAFE LVAEFLPEKA PACAIIKHAN PCGVATAPSL
310 320 330 340 350
AEAYRRALAC DSTSAFGGII ALNQELDAET AEEIVKLFTE VIIAPSVSDD
360 370 380 390 400
AKAVIARKPN LRLLAAGGLP DPRTPGLTAK TVAGGVLVQT RDNGMVEDLE
410 420 430 440 450
LKVVTKRAPT AQELEDMKFA FKVAKHVKSN AIVYAKDGQT AGIGAGQMSR
460 470 480 490 500
VDSARIAAIK AEEAAKAMGL AEPLTRGSAV ASEAFLPFAD GLLSAIAAGA
510 520 530
TAVIQPGGSM RDEEVIAAAN EHDVAMVFTG MRHFRH
Length:536
Mass (Da):56,620
Last modified:December 1, 2001 - v1
Checksum:iD4F9D05109E6BCCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA Translation: CAC47901.1
RefSeqiNP_387428.1, NC_003047.1
WP_010970573.1, NC_003047.1

Genome annotation databases

EnsemblBacteriaiCAC47901; CAC47901; SMc04088
GeneIDi1235016
KEGGisme:SMc04088
PATRICifig|266834.11.peg.4883

Similar proteinsi

Entry informationi

Entry nameiPUR9_RHIME
AccessioniPrimary (citable) accession number: Q92KX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health