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Q92KX6 (PUR9_RHIME) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:R03322
ORF Names:SMc04088
OrganismRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]
Taxonomic identifier266834 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length536 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 536536Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_0000192117

Sequences

Sequence LengthMass (Da)Tools
Q92KX6 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: D4F9D05109E6BCCD

FASTA53656,620
        10         20         30         40         50         60 
MAVASKKIPA PDEVRIKTAL LSVSDKTGIV ELARALNDKG IRLISTGGTH KALADAGLPV 

        70         80         90        100        110        120 
SDVSELTGFP EIMDGRVKTL HPGVHGGLLA IRDDAEHADA MSAHGITAID LAVINLYPFE 

       130        140        150        160        170        180 
EVRAKGGDYP TTVENIDIGG PAMIRASAKN HAYVTIVTDP ADYSPLLEEI ADGATRYAFR 

       190        200        210        220        230        240 
QKMAAKAYAR TAAYDATISN WFAEVLDTPM PRHRVLGGLL REEMRYGENP HQKAGFYVTG 

       250        260        270        280        290        300 
EKRPGVATAA LLQGKQLSYN NINDTDAAFE LVAEFLPEKA PACAIIKHAN PCGVATAPSL 

       310        320        330        340        350        360 
AEAYRRALAC DSTSAFGGII ALNQELDAET AEEIVKLFTE VIIAPSVSDD AKAVIARKPN 

       370        380        390        400        410        420 
LRLLAAGGLP DPRTPGLTAK TVAGGVLVQT RDNGMVEDLE LKVVTKRAPT AQELEDMKFA 

       430        440        450        460        470        480 
FKVAKHVKSN AIVYAKDGQT AGIGAGQMSR VDSARIAAIK AEEAAKAMGL AEPLTRGSAV 

       490        500        510        520        530 
ASEAFLPFAD GLLSAIAAGA TAVIQPGGSM RDEEVIAAAN EHDVAMVFTG MRHFRH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591688 Genomic DNA. Translation: CAC47901.1.
RefSeqNP_387428.1. NC_003047.1.

3D structure databases

ProteinModelPortalQ92KX6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266834.SMc04088.

Proteomic databases

ProMEXQ92KX6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC47901; CAC47901; SMc04088.
GeneID1235016.
KEGGsme:SMc04088.
PATRIC23636322. VBISinMel96828_4883.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMARAFKTDP.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

BioCycSMEL266834:GJF6-3413-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_RHIME
AccessionPrimary (citable) accession number: Q92KX6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways