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Q92KW8

- SYL_RHIME

UniProt

Q92KW8 - SYL_RHIME

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei635 – 6351ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-3422-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:R03331
ORF Names:SMc02804
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 876876Leucine--tRNA ligasePRO_0000152071Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc02804.

Structurei

3D structure databases

ProteinModelPortaliQ92KW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionAdd
BLAST
Motifi632 – 6365"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92KW8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATERYNPRD AEPRWQHQWE AGKVFETKND DPRDKYYVLE MFPYPSGRIH
60 70 80 90 100
MGHVRNYTMG DVVARYKRAR GFNVLHPMGW DAFGMPAENA AMERGVHPAS
110 120 130 140 150
WTYQNIASMK AQLKVMGLSL DWSREFATCD PEYYQRQQHL FLDFLEKGLV
160 170 180 190 200
YRKQSKVNWD PVDNTVLANE QVIEGRGWRS GALVEQRELT QWFFRITDFS
210 220 230 240 250
QDLLDALDTL DEWPEKVRLM QKNWIGRSEG LSVRWELDPA TVPGEEKEVT
260 270 280 290 300
VYTTRPDTLF GASFLAISAD HPLARDAAAK NAEIEAFCEE CRRAGTSLAA
310 320 330 340 350
LETAEKKGID TGIRARHPFD PNWELPVYVA NFVLMDYGTG AIFGCPSGDQ
360 370 380 390 400
RDLDFARKYD LPVVPVVMPK DADPQTFTIG DEAYDGDGVM INSRFLDGLS
410 420 430 440 450
AEEAFETVAS RLENDLLNGT PRAERKVNFR LRDWGISRQR YWGCPIPVIH
460 470 480 490 500
CDDCGVVPVP KADLPVTLPP DVTFDKPGNP LDRHPTWRHV ACPQCGKDAR
510 520 530 540 550
RETDTMDTFV DSSWYFTRFT APWEDNPTDP KAANHWLPVD QYIGGIEHAI
560 570 580 590 600
LHLLYSRFFT RAMKATGHVA LDEPFKGLFT QGMVVHETYS RGEGAQREWI
610 620 630 640 650
TPAEIRVEEV DGQRRAVHIE TGEEVAIGSI EKMSKSKKNV VDPDDIIGSY
660 670 680 690 700
GADTARFFVL SDSPPDRDVI WSEAGVEGAH RFVQRVWRLL TEAAERLRAV
710 720 730 740 750
DAAPASGGEG LAVSQAAHRT LKAVEADYDK LAFNKAVARI YELVNAMAAP
760 770 780 790 800
LTQVASGKAD NALTAAVKDA AAILINLIAP MMPHLAEECW REIGGKGLIA
810 820 830 840 850
ERPWPKFDPA LIVENEITLP VQINGKKRAD LTIARDADQS AIESAVLALD
860 870
AVKAALNGGR PKKIIVVPQR IVNVVV
Length:876
Mass (Da):98,189
Last modified:December 1, 2001 - v1
Checksum:iB483BEDFEA63C084
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA. Translation: CAC47910.1.
RefSeqiNP_387437.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC47910; CAC47910; SMc02804.
GeneIDi1235025.
KEGGisme:SMc02804.
PATRICi23636340. VBISinMel96828_4892.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591688 Genomic DNA. Translation: CAC47910.1 .
RefSeqi NP_387437.1. NC_003047.1.

3D structure databases

ProteinModelPortali Q92KW8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SMc02804.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC47910 ; CAC47910 ; SMc02804 .
GeneIDi 1235025.
KEGGi sme:SMc02804.
PATRICi 23636340. VBISinMel96828_4892.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SMEL266834:GJF6-3422-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiSYL_RHIME
AccessioniPrimary (citable) accession number: Q92KW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3