Q92JQ8 (FABZ_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
EC=4.2.1.59

Alternative name(s):
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase
Short name=(3R)-hydroxymyristoyl-ACP dehydrase
Beta-hydroxyacyl-ACP dehydratase

Gene names

Name:	fabZ
Ordered Locus Names:	RC0009

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia conorii

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs By similarity. HAMAP-Rule MF_00406
Catalytic activity	A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O. HAMAP-Rule MF_00406
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the thioester dehydratase family. FabZ subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 145	145	3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ HAMAP-Rule MF_00406		PRO_0000091720
Sites
	Active site	49	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92JQ8 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: D4F5D14B03B8A456	FASTA	145	16,320
	10 20 30 40 50 60 MIIDITEIMD WIPHRYPFLL VDRVLKIDPN KSITGIKNVT VNEPQFTGHF PARPVMPGVL 70 80 90 100 110 120 MVEAMAQLAA ILVAKSLGST KNKEVFLMTI ENAKFRRIVQ PGDTMHIHAV IDQQRANVWK 130 140 FSSTVTVEGE IATESKFTAM IKDKT

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL02547.1.
PIR	A97701.
RefSeq	NP_359646.1. NC_003103.1.
3D structure databases
ProteinModelPortal	Q92JQ8.
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC0009.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL02547; AAL02547; RC0009.
GeneID	928657.
KEGG	rco:RC0009.
PATRIC	17887084. VBIRicCon45613_0008.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0764.
HOGENOM	HOG000277829.
KO	K02372.
OMA	EYHMKSI.
ProtClustDB	PRK00006.
Family and domain databases
HAMAP	MF_00406. FabZ.
InterPro	IPR013114. FabA_FabZ. IPR010084. FabZ. [Graphical view]
Pfam	PF07977. FabA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01750. fabZ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FABZ_RICCN

Accession

Primary (citable) accession number: Q92JQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program