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Q92JQ7 (LPXD_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-3-O-acylglucosamine N-acyltransferase

EC=2.3.1.-
Gene names
Name:lpxD
Ordered Locus Names:RC0010
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00523

Catalytic activity

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein]. HAMAP-Rule MF_00523

Pathway

Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. HAMAP-Rule MF_00523

Subunit structure

Homotrimer By similarity. HAMAP-Rule MF_00523

Sequence similarities

Belongs to the transferase hexapeptide repeat family. LpxD subfamily.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   DomainRepeat
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functiontransferase activity, transferring acyl groups other than amino-acyl groups

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346UDP-3-O-acylglucosamine N-acyltransferase HAMAP-Rule MF_00523
PRO_0000059697

Sites

Active site2531Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92JQ7 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 825ED46C312B36CF

FASTA34636,882
        10         20         30         40         50         60 
MVSSNFYKNL GPRKLTAIID FLHDIIAPPK IHEDIAIHDI KILQEASPND ISFLSNPKYS 

        70         80         90        100        110        120 
EFLKTTKAAA CIVPKNFTGE ANPNTVLLHA QNPYFAYGKL IDFFYAPIKS YPAKIMKSAI 

       130        140        150        160        170        180 
VADSATIGKN CYIGHNVVIE DDVIIGDNSI IEAGSFIGRG VNIGRNARIE QHVSINYAII 

       190        200        210        220        230        240 
GDDVVILAGA KIGQDGFGFS TEKGVHHKIS HIGIVKIGNN VEIGANTTID RGSLQDTIIK 

       250        260        270        280        290        300 
DLCRIDNLVQ IGHGVKIGKG SIIVAQTGIA GSSTIGKYCT LGGQVGIAGH LNIGDGAQVA 

       310        320        330        340 
AQGGVAQNIE AGKIVGGSPA IPIMDWHRQS IIMKQLLKTS NSKLKK 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL02548.1.
PIRB97701.
RefSeqNP_359647.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92JQ7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC0010.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL02548; AAL02548; RC0010.
GeneID928656.
KEGGrco:RC0010.
PATRIC17887086. VBIRicCon45613_0009.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1044.
HOGENOMHOG000294340.
KOK02536.
OMAKRVVIQS.
OrthoDBEOG6JB11D.
ProtClustDBPRK00892.

Enzyme and pathway databases

UniPathwayUPA00973.

Family and domain databases

HAMAPMF_00523. LpxD.
InterProIPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR011004. Trimer_LpxA-like.
IPR007691. UDP-3-O_GlcNAc_AcTrfase.
IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
[Graphical view]
PfamPF00132. Hexapep. 3 hits.
PF04613. LpxD. 1 hit.
[Graphical view]
SUPFAMSSF51161. SSF51161. 1 hit.
TIGRFAMsTIGR01853. lipid_A_lpxD. 1 hit.
PROSITEPS00101. HEXAPEP_TRANSFERASES. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLPXD_RICCN
AccessionPrimary (citable) accession number: Q92JQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: February 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways