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Q92JQ7

- LPXD_RICCN

UniProt

Q92JQ7 - LPXD_RICCN

Protein

UDP-3-O-acylglucosamine N-acyltransferase

Gene

lpxD

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    (3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein].UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei253 – 2531Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. transferase activity, transferring acyl groups other than amino-acyl groups Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00973.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-3-O-acylglucosamine N-acyltransferaseUniRule annotation (EC:2.3.1.-UniRule annotation)
    Gene namesi
    Name:lpxDUniRule annotation
    Ordered Locus Names:RC0010
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346UDP-3-O-acylglucosamine N-acyltransferasePRO_0000059697Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272944.RC0010.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92JQ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transferase hexapeptide repeat family. LpxD subfamily.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1044.
    HOGENOMiHOG000294340.
    KOiK02536.
    OMAiWANVTLY.
    OrthoDBiEOG6JB11D.

    Family and domain databases

    HAMAPiMF_00523. LpxD.
    InterProiIPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR011004. Trimer_LpxA-like.
    IPR007691. UDP-3-O_GlcNAc_AcTrfase.
    IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
    [Graphical view]
    PfamiPF00132. Hexapep. 3 hits.
    PF04613. LpxD. 1 hit.
    [Graphical view]
    SUPFAMiSSF51161. SSF51161. 1 hit.
    TIGRFAMsiTIGR01853. lipid_A_lpxD. 1 hit.
    PROSITEiPS00101. HEXAPEP_TRANSFERASES. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92JQ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSSNFYKNL GPRKLTAIID FLHDIIAPPK IHEDIAIHDI KILQEASPND    50
    ISFLSNPKYS EFLKTTKAAA CIVPKNFTGE ANPNTVLLHA QNPYFAYGKL 100
    IDFFYAPIKS YPAKIMKSAI VADSATIGKN CYIGHNVVIE DDVIIGDNSI 150
    IEAGSFIGRG VNIGRNARIE QHVSINYAII GDDVVILAGA KIGQDGFGFS 200
    TEKGVHHKIS HIGIVKIGNN VEIGANTTID RGSLQDTIIK DLCRIDNLVQ 250
    IGHGVKIGKG SIIVAQTGIA GSSTIGKYCT LGGQVGIAGH LNIGDGAQVA 300
    AQGGVAQNIE AGKIVGGSPA IPIMDWHRQS IIMKQLLKTS NSKLKK 346
    Length:346
    Mass (Da):36,882
    Last modified:December 1, 2001 - v1
    Checksum:i825ED46C312B36CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02548.1.
    PIRiB97701.
    RefSeqiNP_359647.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL02548; AAL02548; RC0010.
    GeneIDi928656.
    KEGGirco:RC0010.
    PATRICi17887086. VBIRicCon45613_0009.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02548.1 .
    PIRi B97701.
    RefSeqi NP_359647.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92JQ7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0010.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL02548 ; AAL02548 ; RC0010 .
    GeneIDi 928656.
    KEGGi rco:RC0010.
    PATRICi 17887086. VBIRicCon45613_0009.

    Phylogenomic databases

    eggNOGi COG1044.
    HOGENOMi HOG000294340.
    KOi K02536.
    OMAi WANVTLY.
    OrthoDBi EOG6JB11D.

    Enzyme and pathway databases

    UniPathwayi UPA00973 .

    Family and domain databases

    HAMAPi MF_00523. LpxD.
    InterProi IPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR011004. Trimer_LpxA-like.
    IPR007691. UDP-3-O_GlcNAc_AcTrfase.
    IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
    [Graphical view ]
    Pfami PF00132. Hexapep. 3 hits.
    PF04613. LpxD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51161. SSF51161. 1 hit.
    TIGRFAMsi TIGR01853. lipid_A_lpxD. 1 hit.
    PROSITEi PS00101. HEXAPEP_TRANSFERASES. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiLPXD_RICCN
    AccessioniPrimary (citable) accession number: Q92JQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia conorii
      (strain Malish 7): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3