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Q92JQ7

- LPXD_RICCN

UniProt

Q92JQ7 - LPXD_RICCN

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Protein

UDP-3-O-acylglucosamine N-acyltransferase

Gene

lpxD

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein].UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei253 – 2531Proton acceptorUniRule annotation

GO - Molecular functioni

  1. transferase activity, transferring acyl groups other than amino-acyl groups Source: UniProtKB-HAMAP

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00973.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-3-O-acylglucosamine N-acyltransferaseUniRule annotation (EC:2.3.1.-UniRule annotation)
Gene namesi
Name:lpxDUniRule annotation
Ordered Locus Names:RC0010
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346UDP-3-O-acylglucosamine N-acyltransferasePRO_0000059697Add
BLAST

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi272944.RC0010.

Structurei

3D structure databases

ProteinModelPortaliQ92JQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family. LpxD subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1044.
HOGENOMiHOG000294340.
KOiK02536.
OMAiWANVTLY.
OrthoDBiEOG6JB11D.

Family and domain databases

HAMAPiMF_00523. LpxD.
InterProiIPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR011004. Trimer_LpxA-like.
IPR007691. UDP-3-O_GlcNAc_AcTrfase.
IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
[Graphical view]
PfamiPF00132. Hexapep. 3 hits.
PF04613. LpxD. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR01853. lipid_A_lpxD. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92JQ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSSNFYKNL GPRKLTAIID FLHDIIAPPK IHEDIAIHDI KILQEASPND
60 70 80 90 100
ISFLSNPKYS EFLKTTKAAA CIVPKNFTGE ANPNTVLLHA QNPYFAYGKL
110 120 130 140 150
IDFFYAPIKS YPAKIMKSAI VADSATIGKN CYIGHNVVIE DDVIIGDNSI
160 170 180 190 200
IEAGSFIGRG VNIGRNARIE QHVSINYAII GDDVVILAGA KIGQDGFGFS
210 220 230 240 250
TEKGVHHKIS HIGIVKIGNN VEIGANTTID RGSLQDTIIK DLCRIDNLVQ
260 270 280 290 300
IGHGVKIGKG SIIVAQTGIA GSSTIGKYCT LGGQVGIAGH LNIGDGAQVA
310 320 330 340
AQGGVAQNIE AGKIVGGSPA IPIMDWHRQS IIMKQLLKTS NSKLKK
Length:346
Mass (Da):36,882
Last modified:December 1, 2001 - v1
Checksum:i825ED46C312B36CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL02548.1.
PIRiB97701.
RefSeqiNP_359647.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL02548; AAL02548; RC0010.
GeneIDi928656.
KEGGirco:RC0010.
PATRICi17887086. VBIRicCon45613_0009.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL02548.1 .
PIRi B97701.
RefSeqi NP_359647.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92JQ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC0010.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL02548 ; AAL02548 ; RC0010 .
GeneIDi 928656.
KEGGi rco:RC0010.
PATRICi 17887086. VBIRicCon45613_0009.

Phylogenomic databases

eggNOGi COG1044.
HOGENOMi HOG000294340.
KOi K02536.
OMAi WANVTLY.
OrthoDBi EOG6JB11D.

Enzyme and pathway databases

UniPathwayi UPA00973 .

Family and domain databases

HAMAPi MF_00523. LpxD.
InterProi IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR011004. Trimer_LpxA-like.
IPR007691. UDP-3-O_GlcNAc_AcTrfase.
IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
[Graphical view ]
Pfami PF00132. Hexapep. 3 hits.
PF04613. LpxD. 1 hit.
[Graphical view ]
SUPFAMi SSF51161. SSF51161. 1 hit.
TIGRFAMsi TIGR01853. lipid_A_lpxD. 1 hit.
PROSITEi PS00101. HEXAPEP_TRANSFERASES. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiLPXD_RICCN
AccessioniPrimary (citable) accession number: Q92JQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia conorii
    (strain Malish 7): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3