Reviewed, UniProtKB/Swiss-Prot Q92JQ7 (LPXD_RICCN)

Names and origin

Protein names

Recommended name:
    UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
    EC=2.3.1.-

Gene names

Name:	lpxD
Ordered Locus Names:	RC0010

Organism

Rickettsia conorii [Complete proteome] [HAMAP]

Taxonomic identifier

781 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] = UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl-carrier-protein]. HAMAP MF_00523
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 3/6. HAMAP MF_00523
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxD subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	acyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase HAMAP MF_00523		PRO_0000059697

Sequences

	Sequence		Length	Mass (Da)
	Q92JQ7-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 825ED46C312B36CF	FASTA	346	36,882
	10 20 30 40 50 60 MVSSNFYKNL GPRKLTAIID FLHDIIAPPK IHEDIAIHDI KILQEASPND ISFLSNPKYS 70 80 90 100 110 120 EFLKTTKAAA CIVPKNFTGE ANPNTVLLHA QNPYFAYGKL IDFFYAPIKS YPAKIMKSAI 130 140 150 160 170 180 VADSATIGKN CYIGHNVVIE DDVIIGDNSI IEAGSFIGRG VNIGRNARIE QHVSINYAII 190 200 210 220 230 240 GDDVVILAGA KIGQDGFGFS TEKGVHHKIS HIGIVKIGNN VEIGANTTID RGSLQDTIIK 250 260 270 280 290 300 DLCRIDNLVQ IGHGVKIGKG SIIVAQTGIA GSSTIGKYCT LGGQVGIAGH LNIGDGAQVA 310 320 330 340 AQGGVAQNIE AGKIVGGSPA IPIMDWHRQS IIMKQLLKTS NSKLKK

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006914 Genomic DNA. Translation: AAL02548.1.
PIR	B97701.
RefSeq	NP_359647.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	928656.
GenomeReviews	Gene locus RC0010 in contig AE006914_GR.
KEGG	rco:RC0010.
NMPDR	fig|272944.1.peg.10.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	SYPAKIM.
Enzyme and pathway databases
BioCyc	RCON272944:RC0010-MON.
Family and domain databases
HAMAP	MF_00523. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR011004. Trimer_LpxA-like. IPR007691. UDP-3-O_GlcNAc_AcTrfase. IPR020573. UDP_GlcNAc_AcTrfase_non-rep. [Graphical view]
Pfam	PF00132. Hexapep. 8 hits. PF04613. LpxD. 1 hit. [Graphical view]
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPXD_RICCN

Accession

Primary (citable) accession number: Q92JQ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	December 1, 2001
Last modified:	December 15, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)