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Q92JQ6 (DUS_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable tRNA-dihydrouridine synthase

EC=1.-.-.-
Gene names
Name:dus
Ordered Locus Names:RC0011
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs By similarity.

Cofactor

FAD By similarity.

Sequence similarities

Belongs to the Dus family.

Sequence caution

The sequence AAL02549.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processtRNA processing
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionflavin adenine dinucleotide binding

Inferred from electronic annotation. Source: InterPro

tRNA dihydrouridine synthase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331Probable tRNA-dihydrouridine synthase
PRO_0000162140

Sequences

Sequence LengthMass (Da)Tools
Q92JQ6 [UniParc].

Last modified March 20, 2007. Version 2.
Checksum: 4B6149340754AB59

FASTA33135,995
        10         20         30         40         50         60 
MIKIGNIELS SNIILAPMSG VTDLEFRRLV KRFGAGLVVS EMVASRAMIV ESRQSLKKSA 

        70         80         90        100        110        120 
IMRDDATSAC VQLAGCEPNV IAEAAKMNEG MGAKIIDLNF GCPAKKVVGG YSGSALMKDE 

       130        140        150        160        170        180 
QLAAKIFEAT VEAVKLPVTV KMRMGWDDNT KNAPTLAKIA ESSGVQMITV HGRTRCQFYS 

       190        200        210        220        230        240 
GNADWDFIRS VKESVKIPVI ANGDITNFAK AKEALQKSGA DGIMVGRGAY GKPWLISQID 

       250        260        270        280        290        300 
HYLKTGEEKS APSIAEQLDI VTEHYEAILD YYGESVGVPI ARKHIGWYSS GLPNSAEFRG 

       310        320        330 
AVNLMNDPLA VKEKIAEFYT SVMETNKLKE F 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL02549.1. Different initiation.
PIRC97701.
RefSeqNP_359648.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92JQ6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC0011.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL02549; AAL02549; RC0011.
GeneID928651.
KEGGrco:RC0011.
PATRIC17887092. VBIRicCon45613_0011.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0042.
HOGENOMHOG000217855.
KOK05540.
OMAYVCEMIT.
OrthoDBEOG6VHZFQ.

Family and domain databases

Gene3D1.10.1200.80. 1 hit.
3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR024036. tRNA-dHydroUridine_Synthase_C.
IPR004652. tRNA_dU_NifR3.
IPR001269. tRNA_hU_synthase.
IPR018517. tRNA_hU_synthase_CS.
[Graphical view]
PANTHERPTHR11082. PTHR11082. 1 hit.
PfamPF01207. Dus. 1 hit.
[Graphical view]
PIRSFPIRSF006621. Dus. 1 hit.
TIGRFAMsTIGR00737. nifR3_yhdG. 1 hit.
PROSITEPS01136. UPF0034. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUS_RICCN
AccessionPrimary (citable) accession number: Q92JQ6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 20, 2007
Last modified: May 14, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names