Reviewed, UniProtKB/Swiss-Prot Q92JQ6 (DUS_RICCN)

Names and origin

Protein names

Recommended name:
    Probable tRNA-dihydrouridine synthase
    EC=1.-.-.-

Gene names

Name:	dus
Ordered Locus Names:	RC0011

Organism

Rickettsia conorii [Complete proteome] [HAMAP]

Taxonomic identifier

781 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs By similarity.
Cofactor	FAD By similarity.
Sequence similarities	Belongs to the dus family.

Ontologies

Keywords
Biological process	tRNA processing
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro tRNA dihydrouridine synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	Probable tRNA-dihydrouridine synthase		PRO_0000162140

Sequences

	Sequence		Length	Mass (Da)
	Q92JQ6-1 [UniParc]. Last modified March 20, 2007. Version 2. Checksum: 4B6149340754AB59	FASTA	331	35,995
	10 20 30 40 50 60 MIKIGNIELS SNIILAPMSG VTDLEFRRLV KRFGAGLVVS EMVASRAMIV ESRQSLKKSA 70 80 90 100 110 120 IMRDDATSAC VQLAGCEPNV IAEAAKMNEG MGAKIIDLNF GCPAKKVVGG YSGSALMKDE 130 140 150 160 170 180 QLAAKIFEAT VEAVKLPVTV KMRMGWDDNT KNAPTLAKIA ESSGVQMITV HGRTRCQFYS 190 200 210 220 230 240 GNADWDFIRS VKESVKIPVI ANGDITNFAK AKEALQKSGA DGIMVGRGAY GKPWLISQID 250 260 270 280 290 300 HYLKTGEEKS APSIAEQLDI VTEHYEAILD YYGESVGVPI ARKHIGWYSS GLPNSAEFRG 310 320 330 AVNLMNDPLA VKEKIAEFYT SVMETNKLKE F

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006914 Genomic DNA. Translation: AAL02549.1. Different initiation.
PIR	C97701.
RefSeq	NP_359648.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	928651.
GenomeReviews	Gene locus RC0011 in contig AE006914_GR.
KEGG	rco:RC0011.
NMPDR	fig|272944.1.peg.11.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	QLAGCEP.
Enzyme and pathway databases
BioCyc	RCON272944:RC0011-MON.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR004652. tRNA_dU_NifR3. IPR001269. tRNA_hU_synthase. IPR018517. tRNA_hU_synthase_CS. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR11082. Du_synth. 1 hit.
Pfam	PF01207. Dus. 1 hit. [Graphical view]
PIRSF	PIRSF006621. Dus. 1 hit.
PROSITE	PS01136. UPF0034. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUS_RICCN

Accession

Primary (citable) accession number: Q92JQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
Last sequence update:	March 20, 2007
Last modified:	December 15, 2009
This is version 39 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)