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Protein

Probable tRNA-dihydrouridine synthase

Gene

dus

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.By similarity

Catalytic activityi

5,6-dihydrouracil in tRNA + NAD(P)+ = uracil in tRNA + NAD(P)H.By similarity

Cofactori

FMNBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei72FMNBy similarity1
Active sitei102Proton donorBy similarity1
Binding sitei141FMNBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 19FMNBy similarity3
Nucleotide bindingi202 – 204FMNBy similarity3
Nucleotide bindingi226 – 227FMNBy similarity2

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase, RNA-binding, tRNA-binding
Biological processtRNA processing
LigandFlavoprotein, FMN, NADP

Enzyme and pathway databases

BioCyciRCON272944:G1FZG-21-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA-dihydrouridine synthase (EC:1.3.1.-)
Gene namesi
Name:dus
Ordered Locus Names:RC0011
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001621401 – 331Probable tRNA-dihydrouridine synthaseAdd BLAST331

Proteomic databases

PRIDEiQ92JQ6

Structurei

3D structure databases

ProteinModelPortaliQ92JQ6
SMRiQ92JQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Dus family.Curated

Phylogenomic databases

HOGENOMiHOG000217855
KOiK05540
OMAiFRNCVNT
OrthoDBiPOG091H02GM

Family and domain databases

CDDicd02801 DUS_like_FMN, 1 hit
Gene3Di1.10.1200.80, 1 hit
3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035587 DUS-like_FMN-bd
IPR024036 tRNA-dHydroUridine_Synthase_C
IPR004652 tRNA_dU_NifR3
IPR001269 tRNA_hU_synthase
IPR018517 tRNA_hU_synthase_CS
PANTHERiPTHR11082 PTHR11082, 1 hit
PTHR11082:SF25 PTHR11082:SF25, 1 hit
PfamiView protein in Pfam
PF01207 Dus, 1 hit
PIRSFiPIRSF006621 Dus, 1 hit
TIGRFAMsiTIGR00737 nifR3_yhdG, 1 hit
PROSITEiView protein in PROSITE
PS01136 UPF0034, 1 hit

Sequencei

Sequence statusi: Complete.

Q92JQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKIGNIELS SNIILAPMSG VTDLEFRRLV KRFGAGLVVS EMVASRAMIV
60 70 80 90 100
ESRQSLKKSA IMRDDATSAC VQLAGCEPNV IAEAAKMNEG MGAKIIDLNF
110 120 130 140 150
GCPAKKVVGG YSGSALMKDE QLAAKIFEAT VEAVKLPVTV KMRMGWDDNT
160 170 180 190 200
KNAPTLAKIA ESSGVQMITV HGRTRCQFYS GNADWDFIRS VKESVKIPVI
210 220 230 240 250
ANGDITNFAK AKEALQKSGA DGIMVGRGAY GKPWLISQID HYLKTGEEKS
260 270 280 290 300
APSIAEQLDI VTEHYEAILD YYGESVGVPI ARKHIGWYSS GLPNSAEFRG
310 320 330
AVNLMNDPLA VKEKIAEFYT SVMETNKLKE F
Length:331
Mass (Da):35,995
Last modified:March 20, 2007 - v2
Checksum:i4B6149340754AB59
GO

Sequence cautioni

The sequence AAL02549 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA Translation: AAL02549.1 Different initiation.
PIRiC97701
RefSeqiWP_029374420.1, NC_003103.1

Genome annotation databases

EnsemblBacteriaiAAL02549; AAL02549; RC0011
GeneIDi928651
KEGGirco:RC0011
PATRICifig|272944.4.peg.11

Similar proteinsi

Entry informationi

Entry nameiDUS_RICCN
AccessioniPrimary (citable) accession number: Q92JQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 20, 2007
Last modified: May 23, 2018
This is version 84 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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