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Q92JQ4

- TSAE_RICCN

UniProt

Q92JQ4 - TSAE_RICCN

Protein

tRNA threonylcarbamoyladenosine biosynthesis protein TsaE

Gene

tsaE

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t6A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei7 – 71ATPBy similarity
    Metal bindingi38 – 381MagnesiumBy similarity
    Metal bindingi104 – 1041MagnesiumBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi34 – 396ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. threonylcarbamoyladenosine biosynthetic process Source: InterPro

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
    Alternative name(s):
    t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE
    Gene namesi
    Name:tsaE
    Ordered Locus Names:RC0013
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 175175tRNA threonylcarbamoyladenosine biosynthesis protein TsaEPRO_0000096216Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272944.RC0013.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92JQ4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TsaE family.Curated

    Phylogenomic databases

    eggNOGiCOG0802.
    HOGENOMiHOG000052239.
    KOiK06925.
    OMAiERANVYH.
    OrthoDBiEOG6GBMHT.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR003442. T6A_TsaE.
    [Graphical view]
    PfamiPF02367. UPF0079. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00150. T6A_YjeE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q92JQ4-1 [UniParc]FASTAAdd to Basket

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    MHTLNSEEET KKLAKLLAQS LKPNDIVLLN GDLGAGKTFF CREIIKYFCG    50
    ENTSIISPTF NLLQTYKASN FTIYHYDLYR LKSPEEIYEL GFEEALNGNL 100
    ILIEWSEIIK HLLTPPLIEV NLEALDNNKR LCSIITNHKE NSQESSLIDF 150
    LQDSPLFDTK LDIQRDKSPT RKVKL 175
    Length:175
    Mass (Da):20,135
    Last modified:December 1, 2001 - v1
    Checksum:i5519BEA60C86ED93
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02551.1.
    PIRiE97701.
    RefSeqiNP_359650.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL02551; AAL02551; RC0013.
    GeneIDi928653.
    KEGGirco:RC0013.
    PATRICi17887098. VBIRicCon45613_0014.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02551.1 .
    PIRi E97701.
    RefSeqi NP_359650.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92JQ4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0013.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL02551 ; AAL02551 ; RC0013 .
    GeneIDi 928653.
    KEGGi rco:RC0013.
    PATRICi 17887098. VBIRicCon45613_0014.

    Phylogenomic databases

    eggNOGi COG0802.
    HOGENOMi HOG000052239.
    KOi K06925.
    OMAi ERANVYH.
    OrthoDBi EOG6GBMHT.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR003442. T6A_TsaE.
    [Graphical view ]
    Pfami PF02367. UPF0079. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00150. T6A_YjeE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiTSAE_RICCN
    AccessioniPrimary (citable) accession number: Q92JQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia conorii
      (strain Malish 7): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3