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Protein

tRNA threonylcarbamoyladenosine biosynthesis protein TsaE

Gene

tsaE

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t6A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7 – 71ATPBy similarity
Metal bindingi38 – 381MagnesiumBy similarity
Metal bindingi104 – 1041MagnesiumBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi34 – 396ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
Alternative name(s):
t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE
Gene namesi
Name:tsaE
Ordered Locus Names:RC0013
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 175175tRNA threonylcarbamoyladenosine biosynthesis protein TsaEPRO_0000096216Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ92JQ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TsaE family.Curated

Phylogenomic databases

eggNOGiCOG0802.
HOGENOMiHOG000052239.
KOiK06925.
OMAiETENCVI.
OrthoDBiEOG6GBMHT.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR003442. T6A_TsaE.
[Graphical view]
PfamiPF02367. UPF0079. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00150. T6A_YjeE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92JQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHTLNSEEET KKLAKLLAQS LKPNDIVLLN GDLGAGKTFF CREIIKYFCG
60 70 80 90 100
ENTSIISPTF NLLQTYKASN FTIYHYDLYR LKSPEEIYEL GFEEALNGNL
110 120 130 140 150
ILIEWSEIIK HLLTPPLIEV NLEALDNNKR LCSIITNHKE NSQESSLIDF
160 170
LQDSPLFDTK LDIQRDKSPT RKVKL
Length:175
Mass (Da):20,135
Last modified:December 1, 2001 - v1
Checksum:i5519BEA60C86ED93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL02551.1.
PIRiE97701.
RefSeqiNP_359650.1. NC_003103.1.
WP_010976701.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL02551; AAL02551; RC0013.
GeneIDi928653.
KEGGirco:RC0013.
PATRICi17887098. VBIRicCon45613_0014.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL02551.1.
PIRiE97701.
RefSeqiNP_359650.1. NC_003103.1.
WP_010976701.1. NC_003103.1.

3D structure databases

ProteinModelPortaliQ92JQ4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL02551; AAL02551; RC0013.
GeneIDi928653.
KEGGirco:RC0013.
PATRICi17887098. VBIRicCon45613_0014.

Phylogenomic databases

eggNOGiCOG0802.
HOGENOMiHOG000052239.
KOiK06925.
OMAiETENCVI.
OrthoDBiEOG6GBMHT.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR003442. T6A_TsaE.
[Graphical view]
PfamiPF02367. UPF0079. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00150. T6A_YjeE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiTSAE_RICCN
AccessioniPrimary (citable) accession number: Q92JQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.