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Q92JQ4 (TSAE_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
Alternative name(s):
t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE
Gene names
Name:tsaE
Ordered Locus Names:RC0013
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length175 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t6A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the TsaE family.

Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentCytoplasm
   LigandATP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processthreonylcarbamoyladenosine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 175175tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
PRO_0000096216

Regions

Nucleotide binding34 – 396ATP By similarity

Sites

Metal binding381Magnesium By similarity
Metal binding1041Magnesium By similarity
Binding site71ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92JQ4 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 5519BEA60C86ED93

FASTA17520,135
        10         20         30         40         50         60 
MHTLNSEEET KKLAKLLAQS LKPNDIVLLN GDLGAGKTFF CREIIKYFCG ENTSIISPTF 

        70         80         90        100        110        120 
NLLQTYKASN FTIYHYDLYR LKSPEEIYEL GFEEALNGNL ILIEWSEIIK HLLTPPLIEV 

       130        140        150        160        170 
NLEALDNNKR LCSIITNHKE NSQESSLIDF LQDSPLFDTK LDIQRDKSPT RKVKL 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL02551.1.
PIRE97701.
RefSeqNP_359650.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92JQ4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC0013.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL02551; AAL02551; RC0013.
GeneID928653.
KEGGrco:RC0013.
PATRIC17887098. VBIRicCon45613_0014.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0802.
HOGENOMHOG000052239.
KOK06925.
OMAERANVYH.
OrthoDBEOG6GBMHT.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR003442. T6A_TsaE.
[Graphical view]
PfamPF02367. UPF0079. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00150. T6A_YjeE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTSAE_RICCN
AccessionPrimary (citable) accession number: Q92JQ4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names