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Q92JQ4

- TSAE_RICCN

UniProt

Q92JQ4 - TSAE_RICCN

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Protein

tRNA threonylcarbamoyladenosine biosynthesis protein TsaE

Gene
tsaE, RC0013
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t6A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7 – 71ATP By similarity
Metal bindingi38 – 381Magnesium By similarity
Metal bindingi104 – 1041Magnesium By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi34 – 396ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. threonylcarbamoyladenosine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
Alternative name(s):
t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE
Gene namesi
Name:tsaE
Ordered Locus Names:RC0013
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 175175tRNA threonylcarbamoyladenosine biosynthesis protein TsaEPRO_0000096216Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272944.RC0013.

Structurei

3D structure databases

ProteinModelPortaliQ92JQ4.

Family & Domainsi

Sequence similaritiesi

Belongs to the TsaE family.

Phylogenomic databases

eggNOGiCOG0802.
HOGENOMiHOG000052239.
KOiK06925.
OMAiERANVYH.
OrthoDBiEOG6GBMHT.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR003442. T6A_TsaE.
[Graphical view]
PfamiPF02367. UPF0079. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00150. T6A_YjeE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92JQ4-1 [UniParc]FASTAAdd to Basket

« Hide

MHTLNSEEET KKLAKLLAQS LKPNDIVLLN GDLGAGKTFF CREIIKYFCG    50
ENTSIISPTF NLLQTYKASN FTIYHYDLYR LKSPEEIYEL GFEEALNGNL 100
ILIEWSEIIK HLLTPPLIEV NLEALDNNKR LCSIITNHKE NSQESSLIDF 150
LQDSPLFDTK LDIQRDKSPT RKVKL 175
Length:175
Mass (Da):20,135
Last modified:December 1, 2001 - v1
Checksum:i5519BEA60C86ED93
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL02551.1.
PIRiE97701.
RefSeqiNP_359650.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL02551; AAL02551; RC0013.
GeneIDi928653.
KEGGirco:RC0013.
PATRICi17887098. VBIRicCon45613_0014.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL02551.1 .
PIRi E97701.
RefSeqi NP_359650.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92JQ4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC0013.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL02551 ; AAL02551 ; RC0013 .
GeneIDi 928653.
KEGGi rco:RC0013.
PATRICi 17887098. VBIRicCon45613_0014.

Phylogenomic databases

eggNOGi COG0802.
HOGENOMi HOG000052239.
KOi K06925.
OMAi ERANVYH.
OrthoDBi EOG6GBMHT.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR003442. T6A_TsaE.
[Graphical view ]
Pfami PF02367. UPF0079. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00150. T6A_YjeE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiTSAE_RICCN
AccessioniPrimary (citable) accession number: Q92JQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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