Q92JP0 (ATP6_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP synthase subunit a

Alternative name(s):
ATP synthase F0 sector subunit a
F-ATPase subunit 6

Gene names

Name:	atpB
Ordered Locus Names:	RC0027

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane By similarity. HAMAP MF_01393
Subunit structure	F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01393.
Sequence similarities	Belongs to the ATPase A chain family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(0) Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ATP synthesis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell proton-transporting ATP synthase complex, coupling factor F(o) Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	hydrogen ion transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	ATP synthase subunit a HAMAP MF_01393		PRO_0000082068
Regions
	Transmembrane	29 – 49	21	Helical; Potential
	Transmembrane	84 – 104	21	Helical; Potential
	Transmembrane	114 – 134	21	Helical; Potential
	Transmembrane	140 – 160	21	Helical; Potential
	Transmembrane	181 – 201	21	Helical; Potential
	Transmembrane	203 – 223	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q92JP0 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 385920FAD422A832	FASTA	242	27,410
	10 20 30 40 50 60 MTHSPLAQFD IKKLIDIKMF GFDVSFTNSS IYMLLASILA LTYFYLAFYN RKLVPSRLQV 70 80 90 100 110 120 SAEIVYNLVA DMLNQNIGVK GRKFIPLVFS LFIFILFCNL LGMTPYSFTT TSHIIVTFTL 130 140 150 160 170 180 AILVFLMVTI VGFVKHGLRF LTLFLPHGTP LWLAPLMIVI ELFTYLARPV SLSLRLAANM 190 200 210 220 230 240 MAGHVLLKVI AGFTVSLMIY LKFLPIPIMV ILIGFEIFVA ILQAYIFTIL SCMYLNDAIN LH

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL02565.1.
PIR	C97703.
RefSeq	NP_359664.1. NC_003103.1.
3D structure databases
ProteinModelPortal	Q92JP0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	928638.
GenomeReviews	Gene locus RC0027 in contig AE006914_GR.
KEGG	rco:RC0027.
NMPDR	fig|272944.1.peg.27.
PATRIC	17887140. VBIRicCon45613_0034.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	AFYNRKL.
ProtClustDB	PRK05815.
Enzyme and pathway databases
BioCyc	RCON272944:RC0027-MONOMER.
Family and domain databases
HAMAP	MF_01393. ATP_synth_a_bact. [Tree]
InterPro	IPR000568. ATPase_F0-cplx_asu. IPR023011. ATPase_F0-cplx_asu_AS. [Graphical view]
Gene3D	G3DSA:1.20.120.220. ATPase_F0_A. 1 hit.
KO	K02108.
PANTHER	PTHR11410. ATPase_F0_A. 1 hit.
Pfam	PF00119. ATP-synt_A. 1 hit. [Graphical view]
PRINTS	PR00123. ATPASEA.
SUPFAM	SSF81336. ATPase_F0_A. 1 hit.
TIGRFAMs	TIGR01131. ATP_synt_6_or_A. 1 hit.
PROSITE	PS00449. ATPASE_A. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATP6_RICCN

Accession

Primary (citable) accession number: Q92JP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program