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Q92JK8

- CLPB_RICCN

UniProt

Q92JK8 - CLPB_RICCN

Protein

Chaperone protein ClpB

Gene

clpB

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi207 – 2148ATP 1By similarity
    Nucleotide bindingi604 – 6118ATP 2By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. nucleoside-triphosphatase activity Source: InterPro

    GO - Biological processi

    1. protein processing Source: InterPro
    2. response to heat Source: InterPro

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chaperone protein ClpB
    Gene namesi
    Name:clpB
    Ordered Locus Names:RC0059
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 857857Chaperone protein ClpBPRO_0000191169Add
    BLAST

    Proteomic databases

    PRIDEiQ92JK8.

    Interactioni

    Subunit structurei

    Homohexamer. The oligomerization is ATP-dependent By similarity.By similarity

    Protein-protein interaction databases

    STRINGi272944.RC0059.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92JK8.
    SMRiQ92JK8. Positions 161-352.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 144144N-terminalBy similarityAdd
    BLAST
    Regioni160 – 341182NBD1By similarityAdd
    BLAST
    Regioni342 – 544203LinkerBy similarityAdd
    BLAST
    Regioni554 – 764211NBD2By similarityAdd
    BLAST
    Regioni765 – 85793C-terminalBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili392 – 523132By similarityAdd
    BLAST

    Domaini

    The N-terminal domain probably functions as a substrate-discriminating domain, recruiting aggregated proteins to the ClpB hexamer and/or stabilizing bound proteins. The NBD2 domain is responsible for oligomerization, whereas the NBD1 domain stabilizes the hexamer probably in an ATP-dependent manner. The movement of the coiled-coil domain is essential for ClpB ability to rescue proteins from an aggregated state, probably by pulling apart large aggregated proteins, which are bound between the coiled-coils motifs of adjacent ClpB subunits in the functional hexamer By similarity.By similarity

    Sequence similaritiesi

    Belongs to the ClpA/ClpB family.Curated

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG0542.
    HOGENOMiHOG000218211.
    KOiK03695.
    OMAiAMETKLV.
    OrthoDBiEOG65F8SM.

    Family and domain databases

    Gene3Di1.10.1780.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR017730. Chaperonin_ClpB.
    IPR019489. Clp_ATPase_C.
    IPR004176. Clp_N.
    IPR001270. ClpA/B.
    IPR018368. ClpA/B_CS1.
    IPR028299. ClpA/B_CS2.
    IPR023150. Dbl_Clp-N.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00004. AAA. 1 hit.
    PF07724. AAA_2. 1 hit.
    PF02861. Clp_N. 2 hits.
    PF10431. ClpB_D2-small. 1 hit.
    [Graphical view]
    PRINTSiPR00300. CLPPROTEASEA.
    SMARTiSM00382. AAA. 2 hits.
    SM01086. ClpB_D2-small. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    TIGRFAMsiTIGR03346. chaperone_ClpB. 1 hit.
    PROSITEiPS00870. CLPAB_1. 1 hit.
    PS00871. CLPAB_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92JK8-1 [UniParc]FASTAAdd to Basket

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    MNIDKFTAHA KSVIASSQLL AAKNDHQQIL PLHLLSSLLS EETGIIQTLI    50
    NNTGGNINLL KDQVQLELNK IPKVQVEGGG QVYSSAEALK VLEKASSIAK 100
    DNGDSFVTIE RIFEALTYDN TIAGKILTNN GINNKKIATA ILQFRKGKKA 150
    DTESAENSYD ALKKYGRDVT ELAESGKLDP IIGRDEEIRR TVQVLSRRMK 200
    NNPVLIGEPG VGKTAIIEGL AQRIFSKDVP ESLINCRIIE LDMGALIAGA 250
    KYRGEFEERL KAVLSEIKES SGEIILFIDE LHLLVGTGKT DGAMDASNLL 300
    KPMLARGELH CIGATTLDEY RKYIEKDAAL ARRFQPVYVS EPTVEDTISI 350
    LRGIKEKYEL HHAVRISDSA IVAAATLSNR YITDRYLPDK AIDLIDEACS 400
    RMKIELSSKP EELDELDRRI IQIKIELAAL KKENDEHSKK KIEHLTTALE 450
    KLESQSYDMG AKWQAEKSKL QQTQKLKEEL DRSRNELERA ERDANLAKAS 500
    ELKYGIIPEI MKKLQEAESM DNKGLLKEIV SESDIASIIS RITGIPIDTM 550
    LSSERERLLV MEQKLRESVI GQDKAIKGVS DAVRRSRAGI QDINRPLGSF 600
    LFLGPTGVGK TELTKALAGF LFDDRNAILR IDMSEYMEKH AISRLIGAPP 650
    GYIGYDQGGV LTEAVRRRPY QVILFDEVEK AHPDIFNIML QILDEGRLTD 700
    SQGITVDFKN TIIVLTSNLG AEILVNQKED EDTYKVKDEV MEYVKAVFKP 750
    EFLNRLDEII LFHRLNRNNI HDIVKIQLES LKKILLAQNI ILEFDESALN 800
    YLAEKGYDPS FGARPLKRLI QREIQNNLAK MILAGEISSG KTVKINSKDK 850
    ELKVTMS 857
    Length:857
    Mass (Da):95,972
    Last modified:December 1, 2001 - v1
    Checksum:i2D34E3A0BCE47C8A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02597.1.
    PIRiC97707.
    RefSeqiNP_359696.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL02597; AAL02597; RC0059.
    GeneIDi928600.
    KEGGirco:RC0059.
    PATRICi17887212. VBIRicCon45613_0070.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02597.1 .
    PIRi C97707.
    RefSeqi NP_359696.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92JK8.
    SMRi Q92JK8. Positions 161-352.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0059.

    Proteomic databases

    PRIDEi Q92JK8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL02597 ; AAL02597 ; RC0059 .
    GeneIDi 928600.
    KEGGi rco:RC0059.
    PATRICi 17887212. VBIRicCon45613_0070.

    Phylogenomic databases

    eggNOGi COG0542.
    HOGENOMi HOG000218211.
    KOi K03695.
    OMAi AMETKLV.
    OrthoDBi EOG65F8SM.

    Family and domain databases

    Gene3Di 1.10.1780.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR017730. Chaperonin_ClpB.
    IPR019489. Clp_ATPase_C.
    IPR004176. Clp_N.
    IPR001270. ClpA/B.
    IPR018368. ClpA/B_CS1.
    IPR028299. ClpA/B_CS2.
    IPR023150. Dbl_Clp-N.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00004. AAA. 1 hit.
    PF07724. AAA_2. 1 hit.
    PF02861. Clp_N. 2 hits.
    PF10431. ClpB_D2-small. 1 hit.
    [Graphical view ]
    PRINTSi PR00300. CLPPROTEASEA.
    SMARTi SM00382. AAA. 2 hits.
    SM01086. ClpB_D2-small. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    TIGRFAMsi TIGR03346. chaperone_ClpB. 1 hit.
    PROSITEi PS00870. CLPAB_1. 1 hit.
    PS00871. CLPAB_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiCLPB_RICCN
    AccessioniPrimary (citable) accession number: Q92JK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia conorii
      (strain Malish 7): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3