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Q92JK8

- CLPB_RICCN

UniProt

Q92JK8 - CLPB_RICCN

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Protein
Chaperone protein ClpB
Gene
clpB, RC0059
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi207 – 2148ATP 1 By similarity
Nucleotide bindingi604 – 6118ATP 2 By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. nucleoside-triphosphatase activity Source: InterPro

GO - Biological processi

  1. protein processing Source: InterPro
  2. response to heat Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein ClpB
Gene namesi
Name:clpB
Ordered Locus Names:RC0059
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 857857Chaperone protein ClpB
PRO_0000191169Add
BLAST

Proteomic databases

PRIDEiQ92JK8.

Interactioni

Subunit structurei

Homohexamer. The oligomerization is ATP-dependent By similarity.

Protein-protein interaction databases

STRINGi272944.RC0059.

Structurei

3D structure databases

ProteinModelPortaliQ92JK8.
SMRiQ92JK8. Positions 161-352.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 144144N-terminal By similarity
Add
BLAST
Regioni160 – 341182NBD1 By similarity
Add
BLAST
Regioni342 – 544203Linker By similarity
Add
BLAST
Regioni554 – 764211NBD2 By similarity
Add
BLAST
Regioni765 – 85793C-terminal By similarity
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili392 – 523132 By similarity
Add
BLAST

Domaini

The N-terminal domain probably functions as a substrate-discriminating domain, recruiting aggregated proteins to the ClpB hexamer and/or stabilizing bound proteins. The NBD2 domain is responsible for oligomerization, whereas the NBD1 domain stabilizes the hexamer probably in an ATP-dependent manner. The movement of the coiled-coil domain is essential for ClpB ability to rescue proteins from an aggregated state, probably by pulling apart large aggregated proteins, which are bound between the coiled-coils motifs of adjacent ClpB subunits in the functional hexamer By similarity.

Sequence similaritiesi

Belongs to the ClpA/ClpB family.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG0542.
HOGENOMiHOG000218211.
KOiK03695.
OMAiAMETKLV.
OrthoDBiEOG65F8SM.

Family and domain databases

Gene3Di1.10.1780.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR017730. Chaperonin_ClpB.
IPR019489. Clp_ATPase_C.
IPR004176. Clp_N.
IPR001270. ClpA/B.
IPR018368. ClpA/B_CS1.
IPR028299. ClpA/B_CS2.
IPR023150. Dbl_Clp-N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF02861. Clp_N. 2 hits.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view]
PRINTSiPR00300. CLPPROTEASEA.
SMARTiSM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03346. chaperone_ClpB. 1 hit.
PROSITEiPS00870. CLPAB_1. 1 hit.
PS00871. CLPAB_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92JK8-1 [UniParc]FASTAAdd to Basket

« Hide

MNIDKFTAHA KSVIASSQLL AAKNDHQQIL PLHLLSSLLS EETGIIQTLI    50
NNTGGNINLL KDQVQLELNK IPKVQVEGGG QVYSSAEALK VLEKASSIAK 100
DNGDSFVTIE RIFEALTYDN TIAGKILTNN GINNKKIATA ILQFRKGKKA 150
DTESAENSYD ALKKYGRDVT ELAESGKLDP IIGRDEEIRR TVQVLSRRMK 200
NNPVLIGEPG VGKTAIIEGL AQRIFSKDVP ESLINCRIIE LDMGALIAGA 250
KYRGEFEERL KAVLSEIKES SGEIILFIDE LHLLVGTGKT DGAMDASNLL 300
KPMLARGELH CIGATTLDEY RKYIEKDAAL ARRFQPVYVS EPTVEDTISI 350
LRGIKEKYEL HHAVRISDSA IVAAATLSNR YITDRYLPDK AIDLIDEACS 400
RMKIELSSKP EELDELDRRI IQIKIELAAL KKENDEHSKK KIEHLTTALE 450
KLESQSYDMG AKWQAEKSKL QQTQKLKEEL DRSRNELERA ERDANLAKAS 500
ELKYGIIPEI MKKLQEAESM DNKGLLKEIV SESDIASIIS RITGIPIDTM 550
LSSERERLLV MEQKLRESVI GQDKAIKGVS DAVRRSRAGI QDINRPLGSF 600
LFLGPTGVGK TELTKALAGF LFDDRNAILR IDMSEYMEKH AISRLIGAPP 650
GYIGYDQGGV LTEAVRRRPY QVILFDEVEK AHPDIFNIML QILDEGRLTD 700
SQGITVDFKN TIIVLTSNLG AEILVNQKED EDTYKVKDEV MEYVKAVFKP 750
EFLNRLDEII LFHRLNRNNI HDIVKIQLES LKKILLAQNI ILEFDESALN 800
YLAEKGYDPS FGARPLKRLI QREIQNNLAK MILAGEISSG KTVKINSKDK 850
ELKVTMS 857
Length:857
Mass (Da):95,972
Last modified:December 1, 2001 - v1
Checksum:i2D34E3A0BCE47C8A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL02597.1.
PIRiC97707.
RefSeqiNP_359696.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL02597; AAL02597; RC0059.
GeneIDi928600.
KEGGirco:RC0059.
PATRICi17887212. VBIRicCon45613_0070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL02597.1 .
PIRi C97707.
RefSeqi NP_359696.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92JK8.
SMRi Q92JK8. Positions 161-352.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC0059.

Proteomic databases

PRIDEi Q92JK8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL02597 ; AAL02597 ; RC0059 .
GeneIDi 928600.
KEGGi rco:RC0059.
PATRICi 17887212. VBIRicCon45613_0070.

Phylogenomic databases

eggNOGi COG0542.
HOGENOMi HOG000218211.
KOi K03695.
OMAi AMETKLV.
OrthoDBi EOG65F8SM.

Family and domain databases

Gene3Di 1.10.1780.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR017730. Chaperonin_ClpB.
IPR019489. Clp_ATPase_C.
IPR004176. Clp_N.
IPR001270. ClpA/B.
IPR018368. ClpA/B_CS1.
IPR028299. ClpA/B_CS2.
IPR023150. Dbl_Clp-N.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF02861. Clp_N. 2 hits.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view ]
PRINTSi PR00300. CLPPROTEASEA.
SMARTi SM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
TIGRFAMsi TIGR03346. chaperone_ClpB. 1 hit.
PROSITEi PS00870. CLPAB_1. 1 hit.
PS00871. CLPAB_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiCLPB_RICCN
AccessioniPrimary (citable) accession number: Q92JK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi