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Q92JK8

- CLPB_RICCN

UniProt

Q92JK8 - CLPB_RICCN

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Protein

Chaperone protein ClpB

Gene

clpB

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi207 – 2148ATP 1By similarity
Nucleotide bindingi604 – 6118ATP 2By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. protein processing Source: InterPro
  2. response to heat Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein ClpB
Gene namesi
Name:clpB
Ordered Locus Names:RC0059
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 857857Chaperone protein ClpBPRO_0000191169Add
BLAST

Proteomic databases

PRIDEiQ92JK8.

Interactioni

Subunit structurei

Homohexamer. The oligomerization is ATP-dependent (By similarity).By similarity

Protein-protein interaction databases

STRINGi272944.RC0059.

Structurei

3D structure databases

ProteinModelPortaliQ92JK8.
SMRiQ92JK8. Positions 161-352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 144144N-terminalBy similarityAdd
BLAST
Regioni160 – 341182NBD1By similarityAdd
BLAST
Regioni342 – 544203LinkerBy similarityAdd
BLAST
Regioni554 – 764211NBD2By similarityAdd
BLAST
Regioni765 – 85793C-terminalBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili392 – 523132By similarityAdd
BLAST

Domaini

The N-terminal domain probably functions as a substrate-discriminating domain, recruiting aggregated proteins to the ClpB hexamer and/or stabilizing bound proteins. The NBD2 domain is responsible for oligomerization, whereas the NBD1 domain stabilizes the hexamer probably in an ATP-dependent manner. The movement of the coiled-coil domain is essential for ClpB ability to rescue proteins from an aggregated state, probably by pulling apart large aggregated proteins, which are bound between the coiled-coils motifs of adjacent ClpB subunits in the functional hexamer (By similarity).By similarity

Sequence similaritiesi

Belongs to the ClpA/ClpB family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG0542.
HOGENOMiHOG000218211.
KOiK03695.
OMAiAMETKLV.
OrthoDBiEOG65F8SM.

Family and domain databases

Gene3Di1.10.1780.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR017730. Chaperonin_ClpB.
IPR019489. Clp_ATPase_C.
IPR004176. Clp_N.
IPR001270. ClpA/B.
IPR018368. ClpA/B_CS1.
IPR028299. ClpA/B_CS2.
IPR023150. Dbl_Clp-N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF02861. Clp_N. 2 hits.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view]
PRINTSiPR00300. CLPPROTEASEA.
SMARTiSM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03346. chaperone_ClpB. 1 hit.
PROSITEiPS00870. CLPAB_1. 1 hit.
PS00871. CLPAB_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92JK8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNIDKFTAHA KSVIASSQLL AAKNDHQQIL PLHLLSSLLS EETGIIQTLI
60 70 80 90 100
NNTGGNINLL KDQVQLELNK IPKVQVEGGG QVYSSAEALK VLEKASSIAK
110 120 130 140 150
DNGDSFVTIE RIFEALTYDN TIAGKILTNN GINNKKIATA ILQFRKGKKA
160 170 180 190 200
DTESAENSYD ALKKYGRDVT ELAESGKLDP IIGRDEEIRR TVQVLSRRMK
210 220 230 240 250
NNPVLIGEPG VGKTAIIEGL AQRIFSKDVP ESLINCRIIE LDMGALIAGA
260 270 280 290 300
KYRGEFEERL KAVLSEIKES SGEIILFIDE LHLLVGTGKT DGAMDASNLL
310 320 330 340 350
KPMLARGELH CIGATTLDEY RKYIEKDAAL ARRFQPVYVS EPTVEDTISI
360 370 380 390 400
LRGIKEKYEL HHAVRISDSA IVAAATLSNR YITDRYLPDK AIDLIDEACS
410 420 430 440 450
RMKIELSSKP EELDELDRRI IQIKIELAAL KKENDEHSKK KIEHLTTALE
460 470 480 490 500
KLESQSYDMG AKWQAEKSKL QQTQKLKEEL DRSRNELERA ERDANLAKAS
510 520 530 540 550
ELKYGIIPEI MKKLQEAESM DNKGLLKEIV SESDIASIIS RITGIPIDTM
560 570 580 590 600
LSSERERLLV MEQKLRESVI GQDKAIKGVS DAVRRSRAGI QDINRPLGSF
610 620 630 640 650
LFLGPTGVGK TELTKALAGF LFDDRNAILR IDMSEYMEKH AISRLIGAPP
660 670 680 690 700
GYIGYDQGGV LTEAVRRRPY QVILFDEVEK AHPDIFNIML QILDEGRLTD
710 720 730 740 750
SQGITVDFKN TIIVLTSNLG AEILVNQKED EDTYKVKDEV MEYVKAVFKP
760 770 780 790 800
EFLNRLDEII LFHRLNRNNI HDIVKIQLES LKKILLAQNI ILEFDESALN
810 820 830 840 850
YLAEKGYDPS FGARPLKRLI QREIQNNLAK MILAGEISSG KTVKINSKDK

ELKVTMS
Length:857
Mass (Da):95,972
Last modified:December 1, 2001 - v1
Checksum:i2D34E3A0BCE47C8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL02597.1.
PIRiC97707.
RefSeqiNP_359696.1. NC_003103.1.
WP_010976745.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL02597; AAL02597; RC0059.
GeneIDi928600.
KEGGirco:RC0059.
PATRICi17887212. VBIRicCon45613_0070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL02597.1 .
PIRi C97707.
RefSeqi NP_359696.1. NC_003103.1.
WP_010976745.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92JK8.
SMRi Q92JK8. Positions 161-352.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC0059.

Proteomic databases

PRIDEi Q92JK8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL02597 ; AAL02597 ; RC0059 .
GeneIDi 928600.
KEGGi rco:RC0059.
PATRICi 17887212. VBIRicCon45613_0070.

Phylogenomic databases

eggNOGi COG0542.
HOGENOMi HOG000218211.
KOi K03695.
OMAi AMETKLV.
OrthoDBi EOG65F8SM.

Family and domain databases

Gene3Di 1.10.1780.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR017730. Chaperonin_ClpB.
IPR019489. Clp_ATPase_C.
IPR004176. Clp_N.
IPR001270. ClpA/B.
IPR018368. ClpA/B_CS1.
IPR028299. ClpA/B_CS2.
IPR023150. Dbl_Clp-N.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF02861. Clp_N. 2 hits.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view ]
PRINTSi PR00300. CLPPROTEASEA.
SMARTi SM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
TIGRFAMsi TIGR03346. chaperone_ClpB. 1 hit.
PROSITEi PS00870. CLPAB_1. 1 hit.
PS00871. CLPAB_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiCLPB_RICCN
AccessioniPrimary (citable) accession number: Q92JK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3