Reviewed, UniProtKB/Swiss-Prot Q92JK6 (GCP_RICCN)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	RC0061

Organism

Rickettsia conorii [Complete proteome] [HAMAP]

Taxonomic identifier

781 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc Probable.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_0000303523
Sites
	Metal binding	112	1	Zinc Potential
	Metal binding	116	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	Q92JK6-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 72B082999B0B7408	FASTA	344	37,302
	10 20 30 40 50 60 MIKILGIESS CDDTAVSIIT ENREILSNII ISQNTEHAVF GGVVPEIAAR SHLSHLDKAL 70 80 90 100 110 120 KNVLKESNTK LTDISTIAAT SGPGLIGGVI VGSMFARSLS SALKKPFIAI NHLEGHALTA 130 140 150 160 170 180 RLTDNIPYPY LLLLASGGHC QFVAVLGLGK YKILGSTIDD AVGEAFDKVA KMLNLAFPGG 190 200 210 220 230 240 PEIEKRAKLG DPHKYKFPKP IINSGNCNMS FSGLKTAVRT LIMTLKEIND TVINDIAASF 250 260 270 280 290 300 QFTIGEILSS KVQDAIRAYE QITNNFDKKN IVIAGGVAAN KYLQKILSSC AKTYGYRLIY 310 320 330 340 PPIHLCTDNA AMIAYAGLER YNNKLFTPLN FCPKARWSLE DISN

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006914 Genomic DNA. Translation: AAL02599.1.
PIR	E97707.
RefSeq	NP_359698.1.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	928604.
GenomeReviews	Gene locus RC0061 in contig AE006914_GR.
KEGG	rco:RC0061.
NMPDR	fig|272944.1.peg.61.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q92JK6.
OMA	CKRALKQ
Enzyme and pathway databases
BioCyc	RCON272944:RC0061-MON.
BRENDA	3.4.24.57. 267518.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_O-sialoglycoprot. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_RICCN

Accession

Primary (citable) accession number: Q92JK6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	December 1, 2001
Last modified:	November 24, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)