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Q92JK6

- TSAD_RICCN

UniProt

Q92JK6 - TSAD_RICCN

Protein

tRNA N6-adenosine threonylcarbamoyltransferase

Gene

tsaD

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.UniRule annotation

    Catalytic activityi

    L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L-threonylcarbamoyladenine(37) in tRNA.UniRule annotation

    Cofactori

    Binds 1 Fe2+ ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi112 – 1121IronUniRule annotation
    Metal bindingi116 – 1161IronUniRule annotation
    Binding sitei167 – 1671SubstrateUniRule annotation
    Binding sitei180 – 1801Substrate; via amide nitrogenUniRule annotation
    Binding sitei280 – 2801SubstrateUniRule annotation
    Metal bindingi308 – 3081IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: UniProtKB-HAMAP
    2. metalloendopeptidase activity Source: InterPro
    3. transferase activity, transferring acyl groups other than amino-acyl groups Source: UniProtKB-HAMAP

    GO - Biological processi

    1. threonylcarbamoyladenosine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA N6-adenosine threonylcarbamoyltransferaseUniRule annotation (EC:2.6.99.4UniRule annotation)
    Alternative name(s):
    N6-L-threonylcarbamoyladenine synthaseUniRule annotation
    Short name:
    t(6)A synthaseUniRule annotation
    t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaDUniRule annotation
    tRNA threonylcarbamoyladenosine biosynthesis protein TsaDUniRule annotation
    Gene namesi
    Name:tsaDUniRule annotation
    Synonyms:gcp
    Ordered Locus Names:RC0061
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 344344tRNA N6-adenosine threonylcarbamoyltransferasePRO_0000303523Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272944.RC0061.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92JK6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni134 – 1385Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the KAE1 / TsaD family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0533.
    HOGENOMiHOG000109568.
    KOiK01409.
    OMAiRDHVKRM.
    OrthoDBiEOG6K402S.

    Family and domain databases

    HAMAPiMF_01445. TsaD.
    InterProiIPR000905. Gcp-like_dom.
    IPR017861. KAE1/YgjD.
    IPR017860. Peptidase_M22_CS.
    IPR022450. TsaD.
    [Graphical view]
    PfamiPF00814. Peptidase_M22. 1 hit.
    [Graphical view]
    PRINTSiPR00789. OSIALOPTASE.
    TIGRFAMsiTIGR00329. gcp_kae1. 1 hit.
    TIGR03723. T6A_YgjD. 1 hit.
    PROSITEiPS01016. GLYCOPROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92JK6-1 [UniParc]FASTAAdd to Basket

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    MIKILGIESS CDDTAVSIIT ENREILSNII ISQNTEHAVF GGVVPEIAAR    50
    SHLSHLDKAL KNVLKESNTK LTDISTIAAT SGPGLIGGVI VGSMFARSLS 100
    SALKKPFIAI NHLEGHALTA RLTDNIPYPY LLLLASGGHC QFVAVLGLGK 150
    YKILGSTIDD AVGEAFDKVA KMLNLAFPGG PEIEKRAKLG DPHKYKFPKP 200
    IINSGNCNMS FSGLKTAVRT LIMTLKEIND TVINDIAASF QFTIGEILSS 250
    KVQDAIRAYE QITNNFDKKN IVIAGGVAAN KYLQKILSSC AKTYGYRLIY 300
    PPIHLCTDNA AMIAYAGLER YNNKLFTPLN FCPKARWSLE DISN 344
    Length:344
    Mass (Da):37,302
    Last modified:December 1, 2001 - v1
    Checksum:i72B082999B0B7408
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02599.1.
    PIRiE97707.
    RefSeqiNP_359698.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL02599; AAL02599; RC0061.
    GeneIDi928604.
    KEGGirco:RC0061.
    PATRICi17887216. VBIRicCon45613_0072.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02599.1 .
    PIRi E97707.
    RefSeqi NP_359698.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92JK6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0061.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL02599 ; AAL02599 ; RC0061 .
    GeneIDi 928604.
    KEGGi rco:RC0061.
    PATRICi 17887216. VBIRicCon45613_0072.

    Phylogenomic databases

    eggNOGi COG0533.
    HOGENOMi HOG000109568.
    KOi K01409.
    OMAi RDHVKRM.
    OrthoDBi EOG6K402S.

    Family and domain databases

    HAMAPi MF_01445. TsaD.
    InterProi IPR000905. Gcp-like_dom.
    IPR017861. KAE1/YgjD.
    IPR017860. Peptidase_M22_CS.
    IPR022450. TsaD.
    [Graphical view ]
    Pfami PF00814. Peptidase_M22. 1 hit.
    [Graphical view ]
    PRINTSi PR00789. OSIALOPTASE.
    TIGRFAMsi TIGR00329. gcp_kae1. 1 hit.
    TIGR03723. T6A_YgjD. 1 hit.
    PROSITEi PS01016. GLYCOPROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiTSAD_RICCN
    AccessioniPrimary (citable) accession number: Q92JK6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia conorii
      (strain Malish 7): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3