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Protein

Membrane protein insertase YidC

Gene

yidC

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein insertase YidCUniRule annotation
Alternative name(s):
Foldase YidCUniRule annotation
Membrane integrase YidCUniRule annotation
Membrane protein YidCUniRule annotation
Gene namesi
Name:yidCUniRule annotation
Ordered Locus Names:RC0074
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000816 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalUniRule annotationAdd
BLAST
Transmembranei334 – 35421HelicalUniRule annotationAdd
BLAST
Transmembranei357 – 37721HelicalUniRule annotationAdd
BLAST
Transmembranei431 – 45121HelicalUniRule annotationAdd
BLAST
Transmembranei476 – 49621HelicalUniRule annotationAdd
BLAST
Transmembranei522 – 54221HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Membrane protein insertase YidCPRO_0000124749Add
BLAST

Interactioni

Subunit structurei

Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000101821.
KOiK03217.
OMAiINPVAGC.
OrthoDBiPOG091H00BE.

Family and domain databases

HAMAPiMF_01810. YidC_type1. 1 hit.
InterProiIPR019998. Membr_insert_YidC.
IPR028055. Membr_insert_YidC/Oxa1_C.
IPR028053. Membr_insert_YidC_N.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERiPTHR12428. PTHR12428. 2 hits.
PfamiPF02096. 60KD_IMP. 1 hit.
PF14849. YidC_periplas. 1 hit.
[Graphical view]
PRINTSiPR00701. 60KDINNERMP.
PR01900. YIDCPROTEIN.
TIGRFAMsiTIGR03593. yidC_nterm. 1 hit.
TIGR03592. yidC_oxa1_cterm. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92JJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNNIINLIA AIILSLSIIF GWQYFVVKPE QKKQQQQIAV QKAENLKKQQ
60 70 80 90 100
LKALVEPATG IVVQEESQVQ RIKIESESLT GSISLKGLRF DDLILKKYKQ
110 120 130 140 150
DLSKNSPEVR LFSPANTENA YFAEVGLVSN LSSVKLPNND TIWNSDSEIL
160 170 180 190 200
SPEKPVHLFW VNEDGVKFLV TITVDENYLF TIEQTIVNNS DKELPVQSYG
210 220 230 240 250
LINRKYIAVE KAVNILHQGP IGCIDENLKE YSYDDIKDKK SEKFAASKVD
260 270 280 290 300
WIGITDKYWL SSLIPDKSSN YSSNFNYALK QGTERYQVDF ISPVQIIKPG
310 320 330 340 350
ENFSIKSRIF AGAKKVDLLD KYEKQYDIKL FDRAIDFGWF YIITKPVFYA
360 370 380 390 400
MNFFYGYVGN FGVSILIVTV IIKLLMFTLA NKSYRSMKKM KNLQPEIDRI
410 420 430 440 450
KNLYSDDKAR LNQEIMALYK KEKVNPVAGC LPILVQIPVF FSIYKVLYVT
460 470 480 490 500
IEMRQAPFYG WIKDLSASDP TTIFNLFGLL PFSPPSFLMI GAWPILMAIT
510 520 530 540 550
MFLQQKMSPE PADPMQAQVM KFMPLIFLFM FSSFPVGLLI YWSWNNILSI
560
IQQYYINKFN
Length:560
Mass (Da):64,444
Last modified:December 1, 2001 - v1
Checksum:iB521D15A76053C94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL02612.1.
PIRiB97709.
RefSeqiWP_010976759.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL02612; AAL02612; RC0074.
GeneIDi928590.
KEGGirco:RC0074.
PATRICi17887246. VBIRicCon45613_0087.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL02612.1.
PIRiB97709.
RefSeqiWP_010976759.1. NC_003103.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL02612; AAL02612; RC0074.
GeneIDi928590.
KEGGirco:RC0074.
PATRICi17887246. VBIRicCon45613_0087.

Phylogenomic databases

HOGENOMiHOG000101821.
KOiK03217.
OMAiINPVAGC.
OrthoDBiPOG091H00BE.

Family and domain databases

HAMAPiMF_01810. YidC_type1. 1 hit.
InterProiIPR019998. Membr_insert_YidC.
IPR028055. Membr_insert_YidC/Oxa1_C.
IPR028053. Membr_insert_YidC_N.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERiPTHR12428. PTHR12428. 2 hits.
PfamiPF02096. 60KD_IMP. 1 hit.
PF14849. YidC_periplas. 1 hit.
[Graphical view]
PRINTSiPR00701. 60KDINNERMP.
PR01900. YIDCPROTEIN.
TIGRFAMsiTIGR03593. yidC_nterm. 1 hit.
TIGR03592. yidC_oxa1_cterm. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYIDC_RICCN
AccessioniPrimary (citable) accession number: Q92JJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.