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Q92JI7

- DEF2_RICCN

UniProt

Q92JI7 - DEF2_RICCN

Protein

Peptide deformylase 2

Gene

def2

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (19 Sep 2002)
      Previous versions | rss
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    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

    Cofactori

    Binds 1 Fe2+ ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi120 – 1201IronUniRule annotation
    Metal bindingi162 – 1621IronUniRule annotation
    Active sitei163 – 1631UniRule annotation
    Metal bindingi166 – 1661IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylase 2UniRule annotation (EC:3.5.1.88UniRule annotation)
    Short name:
    PDF 2UniRule annotation
    Alternative name(s):
    Polypeptide deformylase 2UniRule annotation
    Gene namesi
    Name:def2UniRule annotation
    Ordered Locus Names:RC0080
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 202202Peptide deformylase 2PRO_0000082830Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272944.RC0080.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92JI7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0242.
    HOGENOMiHOG000010827.
    KOiK01462.
    OMAiREYHREY.
    OrthoDBiEOG6PZXGQ.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q92JI7-1 [UniParc]FASTAAdd to Basket

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    MKNENNISLP QYVTLNIQTL NSSEDKTIRI KAKTLNFPLS SEDLRDISIL    50
    EKKYDQEENC AGLAAPQIGI SKCIIIFAVH EDAELKKWHP DLKDTMPKTI 100
    WINPSYKPIG IDKHEDYEGC FSVENATGPV ARFKKIHYHA YDINGNQIQG 150
    IAEGFLARVI QHEIDHLNGK VFLDYVAPKK IMTKEEYLEM RKKAMEQENI 200
    KS 202
    Length:202
    Mass (Da):23,191
    Last modified:September 19, 2002 - v2
    Checksum:i9A108195359D1B82
    GO

    Sequence cautioni

    The sequence AAL02618.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02618.1. Different initiation.
    PIRiH97709.
    RefSeqiNP_359717.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL02618; AAL02618; RC0080.
    GeneIDi928534.
    KEGGirco:RC0080.
    PATRICi17887262. VBIRicCon45613_0095.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02618.1 . Different initiation.
    PIRi H97709.
    RefSeqi NP_359717.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92JI7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0080.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL02618 ; AAL02618 ; RC0080 .
    GeneIDi 928534.
    KEGGi rco:RC0080.
    PATRICi 17887262. VBIRicCon45613_0095.

    Phylogenomic databases

    eggNOGi COG0242.
    HOGENOMi HOG000010827.
    KOi K01462.
    OMAi REYHREY.
    OrthoDBi EOG6PZXGQ.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiDEF2_RICCN
    AccessioniPrimary (citable) accession number: Q92JI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: September 19, 2002
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia conorii
      (strain Malish 7): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3