Q92JI4 (NDK_RICCN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 72.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Nucleoside diphosphate kinase Short name=NDK Short name=NDP kinase EC=2.7.4.6 Alternative name(s): Nucleoside-2-P kinase | ||||
| Gene names |
| ||||
| Organism | Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 272944 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › ![]() |
Protein attributes
| Sequence length | 140 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate By similarity. HAMAP-Rule MF_00451 |
| Catalytic activity | ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. HAMAP-Rule MF_00451 |
| Cofactor | Magnesium By similarity. |
| Subunit structure | Homotetramer By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the NDK family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide metabolism |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological_process | CTP biosynthetic process Inferred from electronic annotation. Source: HAMAP GTP biosynthetic processInferred from electronic annotation. Source: HAMAP UTP biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Cellular_component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | ATP binding Inferred from electronic annotation. Source: HAMAP metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW nucleoside diphosphate kinase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 140 | 140 | Nucleoside diphosphate kinase HAMAP-Rule MF_00451 | PRO_0000137033 | |||||
Sites | |||||||||
| Active site | 117 | 1 | Pros-phosphohistidine intermediate By similarity | ||||||
| Binding site | 11 | 1 | ATP By similarity | ||||||
| Binding site | 59 | 1 | ATP By similarity | ||||||
| Binding site | 87 | 1 | ATP By similarity | ||||||
| Binding site | 93 | 1 | ATP By similarity | ||||||
| Binding site | 104 | 1 | ATP By similarity | ||||||
| Binding site | 114 | 1 | ATP By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE006914 Genomic DNA. Translation: AAL02621.1. |
| PIR | C97710. |
| RefSeq | NP_359720.1. NC_003103.1. |
3D structure databases | |
| ProteinModelPortal | Q92JI4. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 272944.RC0083. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | AAL02621; AAL02621; RC0083. |
| GeneID | 928531. |
| KEGG | rco:RC0083. |
| PATRIC | 17887272. VBIRicCon45613_0100. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0105. |
| HOGENOM | HOG000224565. |
| KO | K00940. |
| OMA | AEGFYYV. |
| ProtClustDB | PRK00668. |
Family and domain databases | |
| Gene3D | 3.30.70.141. 1 hit. |
| HAMAP | MF_00451. NDP_kinase. |
| InterPro | IPR001564. Nucleoside_diP_kinase. IPR023005. Nucleoside_diP_kinase_AS. [Graphical view] |
| PANTHER | PTHR11349. PTHR11349. 1 hit. |
| Pfam | PF00334. NDK. 1 hit. [Graphical view] |
| PRINTS | PR01243. NUCDPKINASE. |
| SMART | SM00562. NDK. 1 hit. [Graphical view] |
| SUPFAM | SSF54919. NDK. 1 hit. |
| PROSITE | PS00469. NDP_KINASES. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | NDK_RICCN | ||||||||
| Accession | Primary (citable) accession number: Q92JI4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Rickettsia conorii (strain Malish 7): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with
