Q92JH7 (KDSA_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-dehydro-3-deoxyphosphooctonate aldolase
EC=2.5.1.55

Alternative name(s):
3-deoxy-D-manno-octulosonic acid 8-phosphate synthase
KDO-8-phosphate synthase
Short name=KDO 8-P synthase
Short name=KDOPS
Phospho-2-dehydro-3-deoxyoctonate aldolase

Gene names

Name:	kdsA
Ordered Locus Names:	RC0090

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. HAMAP MF_00056
Pathway	Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3. HAMAP MF_00056 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00056
Subcellular location	Cytoplasm By similarity HAMAP MF_00056.
Sequence similarities	Belongs to the KdsA family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-deoxy-8-phosphooctulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	2-dehydro-3-deoxyphosphooctonate aldolase HAMAP MF_00056		PRO_0000187159

Sequences

	Sequence		Length	Mass (Da)
	Q92JH7 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 8DD10B8B8FFDC735	FASTA	274	30,030
	10 20 30 40 50 60 MQKVVKLNNI KIGNDLPFVL ITGPCQIEGK DHALFMAEKL VKLTSKLEIP FIYKSSFDKA 70 80 90 100 110 120 NRTSVHGIRG VGIEKGLEIL SKVKSEFDCP IVTDVHSESQ CTETAEVADI LQIPAFLCRQ 130 140 150 160 170 180 TDLLQAAAKT GKIVKVKKGQ FLAPWDMKNV QTKLEAFGVK DILFTERGAC FGYNNLVSDM 190 200 210 220 230 240 RSLAIMAELN VPVVFDATHS VQQPGGLGGS TGGERKYVEL LAKAATSVGI AGIYMEVHQD 250 260 270 PDNAPSDGPC MMKLDNLESI LIKLKKYDKI TKEK

References

[1]	"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL02628.1.
PIR	B97711.
RefSeq	NP_359727.1. NC_003103.1.
3D structure databases
ProteinModelPortal	Q92JH7.
SMR	Q92JH7. Positions 17-271.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	928110.
GenomeReviews	Gene locus RC0090 in contig AE006914_GR.
KEGG	rco:RC0090.
NMPDR	fig|272944.1.peg.90.
PATRIC	17887286. VBIRicCon45613_0107.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	ITERGAM.
ProtClustDB	PRK05198.
Enzyme and pathway databases
BioCyc	RCON272944:RC0090-MONOMER.
Family and domain databases
HAMAP	MF_00056. KDO8P_synth. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006269. KDO8P_synthase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01627.
PANTHER	PTHR21057:SF2. KDO8P_synthase. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01362. KDO8P_synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDSA_RICCN

Accession

Primary (citable) accession number: Q92JH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program