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Q92JH7 (KDSA_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-dehydro-3-deoxyphosphooctonate aldolase

EC=2.5.1.55
Alternative name(s):
3-deoxy-D-manno-octulosonic acid 8-phosphate synthase
KDO-8-phosphate synthase
Short name=KDO 8-P synthase
Short name=KDOPS
Phospho-2-dehydro-3-deoxyoctonate aldolase
Gene names
Name:kdsA
Ordered Locus Names:RC0090
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. HAMAP-Rule MF_00056

Pathway

Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3. HAMAP-Rule MF_00056

Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP-Rule MF_00056

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00056.

Sequence similarities

Belongs to the KdsA family.

Ontologies

Keywords
   Biological processLipopolysaccharide biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processketo-3-deoxy-D-manno-octulosonic acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-deoxy-8-phosphooctulonate synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2742742-dehydro-3-deoxyphosphooctonate aldolase HAMAP-Rule MF_00056
PRO_0000187159

Sequences

Sequence LengthMass (Da)Tools
Q92JH7 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 8DD10B8B8FFDC735

FASTA27430,030
        10         20         30         40         50         60 
MQKVVKLNNI KIGNDLPFVL ITGPCQIEGK DHALFMAEKL VKLTSKLEIP FIYKSSFDKA 

        70         80         90        100        110        120 
NRTSVHGIRG VGIEKGLEIL SKVKSEFDCP IVTDVHSESQ CTETAEVADI LQIPAFLCRQ 

       130        140        150        160        170        180 
TDLLQAAAKT GKIVKVKKGQ FLAPWDMKNV QTKLEAFGVK DILFTERGAC FGYNNLVSDM 

       190        200        210        220        230        240 
RSLAIMAELN VPVVFDATHS VQQPGGLGGS TGGERKYVEL LAKAATSVGI AGIYMEVHQD 

       250        260        270 
PDNAPSDGPC MMKLDNLESI LIKLKKYDKI TKEK 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL02628.1.
PIRB97711.
RefSeqNP_359727.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92JH7.
SMRQ92JH7. Positions 17-271.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC0090.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL02628; AAL02628; RC0090.
GeneID928110.
KEGGrco:RC0090.
PATRIC17887286. VBIRicCon45613_0107.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2877.
HOGENOMHOG000023021.
KOK01627.
OMAMESREHA.
OrthoDBEOG680X4R.

Enzyme and pathway databases

UniPathwayUPA00030.
UPA00357; UER00474.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00056. KDO8P_synth.
InterProIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006269. KDO8P_synthase.
[Graphical view]
PANTHERPTHR21057:SF2. PTHR21057:SF2. 1 hit.
PfamPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
TIGRFAMsTIGR01362. KDO8P_synth. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKDSA_RICCN
AccessionPrimary (citable) accession number: Q92JH7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways