Reviewed, UniProtKB/Swiss-Prot Q92JH2 (SYR_RICCN)

Names and origin

Protein names

Recommended name:
    Arginyl-tRNA synthetase
    EC=6.1.1.19
Alternative name(s):
    Arginine--tRNA ligase
      Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	RC0095

Organism

Rickettsia conorii [Complete proteome] [HAMAP]

Taxonomic identifier

781 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	576 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP arginine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 576	576	Arginyl-tRNA synthetase HAMAP MF_00123		PRO_0000151599
Regions
	Motif	128 – 136	9	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	Q92JH2-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 8486A96C2380337D	FASTA	576	65,234
	10 20 30 40 50 60 MNIFNQLKQD IIVASRQLYN NQEIANTATI EIPKDSFNGD LSSNIAMIIA AKESIAPREV 70 80 90 100 110 120 ALKFKEVLIT LPYIASIEIA GPGFINFTIK ADSWQASIKD ILQHEEKFFE IDIDKSRNIN 130 140 150 160 170 180 IEYVSANPTG PMHIGHARGA VYGDVLARIL QKVSYSVTKE YYVNDAGSQI NDLVSTVLLR 190 200 210 220 230 240 YKEALGEQIT IPAGLYPGEY LIPLGQILAK EYGNKLLTMN YAERFKIIKS FAVEKMLDLN 250 260 270 280 290 300 RKDLADLGIK HDIFFSEQSL HDKGEIEETV KLLERMGLIY EGTLPAPKGK IHEEWDNRVQ 310 320 330 340 350 360 KLFKSTKYGD SQDRPIEKAD GSWSYFASDL AYAKDKIERG ANHLIYVLGA DHSGYVKRIE 370 380 390 400 410 420 AIVKALGKEQ VKVDVKICQL VNFVENGVPV KMSKRLGSFA SVQDVNHEVG KDIIRFMMLT 430 440 450 460 470 480 RQNDKPLDFD LVKVKEQSRE NPIFYVQYAH VRTISILSKA KELMPESYNN FESGKYDLSL 490 500 510 520 530 540 LSSEEEIEII KLLASWTKTL EASAKYFEPH RIAFYLINLA SKFHSMWNFG KENSDYRFVI 550 560 570 ESNKELTLAR LALASAIQKV IASGLEVIGV EPMNKM

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006914 Genomic DNA. Translation: AAL02633.1.
PIR	G97711.
RefSeq	NP_359732.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	928099.
GenomeReviews	Gene locus RC0095 in contig AE006914_GR.
KEGG	rco:RC0095.
NMPDR	fig|272944.1.peg.95.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q92JH2.
OMA	LGDCIAN
Enzyme and pathway databases
BioCyc	RCON272944:RC0095-MON.
BRENDA	6.1.1.19. 267518.
Family and domain databases
HAMAP	MF_00123. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ic. IPR015945. Arg-tRNA-synth_Ic_core. IPR005148. Arg-tRNA-synth_Ic_N. IPR008909. DALR_anticod_bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM00836. DALR_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_RICCN

Accession

Primary (citable) accession number: Q92JH2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2002
Last sequence update:	December 1, 2001
Last modified:	November 24, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)