Reviewed, UniProtKB/Swiss-Prot Q92JH0 (PARC_RICCN)

Names and origin

Protein names

Recommended name:
    DNA topoisomerase 4 subunit A
    EC=5.99.1.-
Alternative name(s):
    Topoisomerase IV subunit A

Gene names

Name:	parC
Ordered Locus Names:	RC0097

Organism

Rickettsia conorii [Complete proteome] [HAMAP]

Taxonomic identifier

781 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	738 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Topoisomerase IV is essential for chromosome segregation. It has relaxation of supercoiled DNA activity. Performs the decatenation events required during the replication of a circular DNA molecule By similarity.
Subunit structure	Composed of two subunits: parC and parE By similarity.
Subcellular location	Cell membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the topoisomerase gyrA/parC subunit family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Ligand	DNA-binding
Molecular function	Isomerase Topoisomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 738	738	DNA topoisomerase 4 subunit A		PRO_0000145405
Sites
	Active site	120	1	O-(5'-phospho-DNA)-tyrosine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92JH0-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: C932298ADDC667AF	FASTA	738	83,246
	10 20 30 40 50 60 MKEAKVENID FGNALSERYL AYALSTIMSR SLPDVRDGLK PVHRRLLYAM LQLRLEPNSG 70 80 90 100 110 120 YKKCARVVGD VIGKYHPHGD VAVYDTLVRL AQHFSLRYPL IDGQGNFGSI DGDNAAAMRY 130 140 150 160 170 180 TESRMTDICT LLMEDIDKDT VDFRPTYDGS DLEPVIMPAS FPNLLANGSE GIAVGMATNI 190 200 210 220 230 240 PPHNLHELCD ALIHLINHPK AEINDIINFV KGPDFPTGGI IIDKAEVINA AYTTGRGSLR 250 260 270 280 290 300 VRSRWEKEEL SYGTYQIVVT EIPYQVQKSK LIEQIAILLK DKKIPLVSNI RDESTDIIRL 310 320 330 340 350 360 VIEPRDRGCD PQIVMESLFK LTNLESRIQL NMNVIGSNNV PRVMNILEIL QEFLYHRQNI 370 380 390 400 410 420 VTRRSTYLLN KIKHRLEILK GLRIAYLNLD EIIKIIREED EPKAIMMEWF KLTEIQVEAI 430 440 450 460 470 480 LNTRLRSLRK LEEQEIINEH SNLQKQQAIL EEILNNPKEL WKIVKKEIKT VQTKFGLNTV 490 500 510 520 530 540 IGARRTSFEE VTLTNQVVDI TAFITKEPIT IICSKMGWVR SLKGHNTDLS TIKYKEGDAE 550 560 570 580 590 600 KFILEAYTTD KILIVSSEGR FFTLLADNIS KGKGTGESIK LLVDIGNNDI TNILVYKPDQ 610 620 630 640 650 660 LLLLASSVGK GFLVNSNEVM AQTKTGKQIM NVPDGHVCIA CLPVNGDSIA CIGESRKLLV 670 680 690 700 710 720 FNIDEIPEMK KGQGVTLQKF KNAKLLDIKI FNKEDGLGWN NNGKVKLEKN IVAFLGKRGS 730 TGKLPPMGFP KNNRFSSY

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006914 Genomic DNA. Translation: AAL02635.1.
PIR	A97712.
RefSeq	NP_359734.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	928101.
GenomeReviews	Gene locus RC0097 in contig AE006914_GR.
KEGG	rco:RC0097.
NMPDR	fig|272944.1.peg.97.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	CDAALHL.
Enzyme and pathway databases
BioCyc	RCON272944:RC0097-MON.
Family and domain databases
InterPro	IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. IPR005742. TopoIV_A_Gneg. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
Pfam	PF03989. DNA_gyraseA_C. 2 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
TIGRFAMs	TIGR01062. parC_Gneg. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PARC_RICCN

Accession

Primary (citable) accession number: Q92JH0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
Last sequence update:	December 1, 2001
Last modified:	December 15, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)