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Q92JE9

- KDTA_RICCN

UniProt

Q92JE9 - KDTA_RICCN

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Protein
3-deoxy-D-manno-octulosonic acid transferase
Gene
waaA, kdtA, RC0118
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A By similarity.

Catalytic activityi

Lipid IV(A) + CMP-alpha-Kdo = alpha-Kdo-(2->6)-lipid IV(A) + CMP.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei107 – 1071Proton acceptor By similarity
Sitei177 – 1771Transition state stabilizer By similarity
Sitei252 – 2521Transition state stabilizer By similarity

GO - Molecular functioni

  1. transferase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. lipopolysaccharide core region biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00958.

Protein family/group databases

CAZyiGT30. Glycosyltransferase Family 30.

Names & Taxonomyi

Protein namesi
Recommended name:
3-deoxy-D-manno-octulosonic acid transferase (EC:2.4.99.12)
Short name:
Kdo transferase
Alternative name(s):
Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase
Gene namesi
Name:waaA
Synonyms:kdtA
Ordered Locus Names:RC0118
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221Helical; Signal-anchor; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4644643-deoxy-D-manno-octulosonic acid transferase
PRO_0000286455Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272944.RC0118.

Structurei

3D structure databases

ProteinModelPortaliQ92JE9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 9347RPE1 insert
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni311 – 3122CMP-Kdo binding By similarity
Regioni352 – 3543CMP-Kdo binding By similarity
Regioni377 – 3804CMP-Kdo binding By similarity

Sequence similaritiesi

Contains 1 RPE1 insert domain.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1519.
HOGENOMiHOG000010628.
KOiK02527.
OMAiLPYDLPC.
OrthoDBiEOG6H7FNN.

Family and domain databases

InterProiIPR007507. Glycos_transf_N.
IPR005728. Rickett_RPE.
[Graphical view]
PfamiPF04413. Glycos_transf_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01045. RPE1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92JE9-1 [UniParc]FASTAAdd to Basket

« Hide

MMLLYYALSF ILLPVYFIII LIRLLIGKED IRRIQERFAI GKHRQDDSLD    50
FMQTSANKEE FKGDTSLRTT TYTLIREDEG LGSTYKLPLE ASDARRLIWI 100
NAASIGESMV ALTLIHNISK RYPDVRFLVT SWTNSSAKIL TAKLPKIAVH 150
QFLPIDNIIF TRKFLRNWQP DLGIFIESEL WPCTINEGAK QCKLLLVNAR 200
ISDKSFKAWL QRKSFFQLIL KNCSKIIVQS ERDLQKFNEL GVSDAVNLGN 250
IKFANEKLPV NQEELSKLSL HLDNKRVVLF ASTHPEDEEV ILPIIKNLKE 300
QFLDCYIILI PRHPERVKSI IDNCKSHNLS ATAKSQNDLP VLSDDLYIVD 350
RFGEMGLFFS VATISFIGGS FKQGGHNILE AAYFSNCIIF GPDMSKNTDI 400
AKGVLQNEAA IQIKNGEDLL TKLTYLLRSN NALELTTYRE NALKFIKDNQ 450
KVLDEYLNVI TKFL 464
Length:464
Mass (Da):53,047
Last modified:December 1, 2001 - v1
Checksum:i476C023C396CFCFA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL02656.1.
PIRiF97714.
RefSeqiNP_359755.1. NC_003103.1.
WP_010976798.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL02656; AAL02656; RC0118.
GeneIDi928074.
KEGGirco:RC0118.
PATRICi17887355. VBIRicCon45613_0140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL02656.1 .
PIRi F97714.
RefSeqi NP_359755.1. NC_003103.1.
WP_010976798.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92JE9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272944.RC0118.

Protein family/group databases

CAZyi GT30. Glycosyltransferase Family 30.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL02656 ; AAL02656 ; RC0118 .
GeneIDi 928074.
KEGGi rco:RC0118.
PATRICi 17887355. VBIRicCon45613_0140.

Phylogenomic databases

eggNOGi COG1519.
HOGENOMi HOG000010628.
KOi K02527.
OMAi LPYDLPC.
OrthoDBi EOG6H7FNN.

Enzyme and pathway databases

UniPathwayi UPA00958 .

Family and domain databases

InterProi IPR007507. Glycos_transf_N.
IPR005728. Rickett_RPE.
[Graphical view ]
Pfami PF04413. Glycos_transf_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01045. RPE1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiKDTA_RICCN
AccessioniPrimary (citable) accession number: Q92JE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia conorii
    (strain Malish 7): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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