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Q92JE9

- KDTA_RICCN

UniProt

Q92JE9 - KDTA_RICCN

Protein

3-deoxy-D-manno-octulosonic acid transferase

Gene

waaA

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A By similarity.By similarity

    Catalytic activityi

    Lipid IV(A) + CMP-alpha-Kdo = alpha-Kdo-(2->6)-lipid IV(A) + CMP.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei107 – 1071Proton acceptorBy similarity
    Sitei177 – 1771Transition state stabilizerBy similarity
    Sitei252 – 2521Transition state stabilizerBy similarity

    GO - Molecular functioni

    1. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. lipopolysaccharide core region biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Lipopolysaccharide biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00958.

    Protein family/group databases

    CAZyiGT30. Glycosyltransferase Family 30.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-deoxy-D-manno-octulosonic acid transferase (EC:2.4.99.12)
    Short name:
    Kdo transferase
    Alternative name(s):
    Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase
    Gene namesi
    Name:waaA
    Synonyms:kdtA
    Ordered Locus Names:RC0118
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    Subcellular locationi

    Cell inner membrane By similarity; Single-pass membrane protein By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4644643-deoxy-D-manno-octulosonic acid transferasePRO_0000286455Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272944.RC0118.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92JE9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221Helical; Signal-anchorSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini47 – 9347RPE1 insertAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni311 – 3122CMP-Kdo bindingBy similarity
    Regioni352 – 3543CMP-Kdo bindingBy similarity
    Regioni377 – 3804CMP-Kdo bindingBy similarity

    Sequence similaritiesi

    Contains 1 RPE1 insert domain.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1519.
    HOGENOMiHOG000010628.
    KOiK02527.
    OMAiLPYDLPC.
    OrthoDBiEOG6H7FNN.

    Family and domain databases

    InterProiIPR007507. Glycos_transf_N.
    IPR005728. Rickett_RPE.
    [Graphical view]
    PfamiPF04413. Glycos_transf_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01045. RPE1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q92JE9-1 [UniParc]FASTAAdd to Basket

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    MMLLYYALSF ILLPVYFIII LIRLLIGKED IRRIQERFAI GKHRQDDSLD    50
    FMQTSANKEE FKGDTSLRTT TYTLIREDEG LGSTYKLPLE ASDARRLIWI 100
    NAASIGESMV ALTLIHNISK RYPDVRFLVT SWTNSSAKIL TAKLPKIAVH 150
    QFLPIDNIIF TRKFLRNWQP DLGIFIESEL WPCTINEGAK QCKLLLVNAR 200
    ISDKSFKAWL QRKSFFQLIL KNCSKIIVQS ERDLQKFNEL GVSDAVNLGN 250
    IKFANEKLPV NQEELSKLSL HLDNKRVVLF ASTHPEDEEV ILPIIKNLKE 300
    QFLDCYIILI PRHPERVKSI IDNCKSHNLS ATAKSQNDLP VLSDDLYIVD 350
    RFGEMGLFFS VATISFIGGS FKQGGHNILE AAYFSNCIIF GPDMSKNTDI 400
    AKGVLQNEAA IQIKNGEDLL TKLTYLLRSN NALELTTYRE NALKFIKDNQ 450
    KVLDEYLNVI TKFL 464
    Length:464
    Mass (Da):53,047
    Last modified:December 1, 2001 - v1
    Checksum:i476C023C396CFCFA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02656.1.
    PIRiF97714.
    RefSeqiNP_359755.1. NC_003103.1.
    WP_010976798.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL02656; AAL02656; RC0118.
    GeneIDi928074.
    KEGGirco:RC0118.
    PATRICi17887355. VBIRicCon45613_0140.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02656.1 .
    PIRi F97714.
    RefSeqi NP_359755.1. NC_003103.1.
    WP_010976798.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92JE9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0118.

    Protein family/group databases

    CAZyi GT30. Glycosyltransferase Family 30.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL02656 ; AAL02656 ; RC0118 .
    GeneIDi 928074.
    KEGGi rco:RC0118.
    PATRICi 17887355. VBIRicCon45613_0140.

    Phylogenomic databases

    eggNOGi COG1519.
    HOGENOMi HOG000010628.
    KOi K02527.
    OMAi LPYDLPC.
    OrthoDBi EOG6H7FNN.

    Enzyme and pathway databases

    UniPathwayi UPA00958 .

    Family and domain databases

    InterProi IPR007507. Glycos_transf_N.
    IPR005728. Rickett_RPE.
    [Graphical view ]
    Pfami PF04413. Glycos_transf_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01045. RPE1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiKDTA_RICCN
    AccessioniPrimary (citable) accession number: Q92JE9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia conorii
      (strain Malish 7): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3