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Protein

3-deoxy-D-manno-octulosonic acid transferase

Gene

waaA

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.By similarity

Catalytic activityi

Lipid IV(A) + CMP-beta-Kdo = alpha-Kdo-(2->6)-lipid IV(A) + CMP.

Pathwayi: LPS core biosynthesis

This protein is involved in the pathway LPS core biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway LPS core biosynthesis and in Bacterial outer membrane biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei107Proton acceptorBy similarity1
Sitei177Transition state stabilizerBy similarity1
Sitei252Transition state stabilizerBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciRCON272944:G1FZG-185-MONOMER
UniPathwayiUPA00958

Protein family/group databases

CAZyiGT30 Glycosyltransferase Family 30

Names & Taxonomyi

Protein namesi
Recommended name:
3-deoxy-D-manno-octulosonic acid transferase (EC:2.4.99.12)
Short name:
Kdo transferase
Alternative name(s):
Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase
Gene namesi
Name:waaA
Synonyms:kdtA
Ordered Locus Names:RC0118
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000816 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22Helical; Signal-anchorSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002864551 – 4643-deoxy-D-manno-octulosonic acid transferaseAdd BLAST464

Structurei

3D structure databases

ProteinModelPortaliQ92JE9
SMRiQ92JE9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 93RPE1 insertAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni311 – 312CMP-Kdo bindingBy similarity2
Regioni352 – 354CMP-Kdo bindingBy similarity3
Regioni377 – 380CMP-Kdo bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000010628
KOiK02527
OMAiFIKYEFW
OrthoDBiPOG091H01YQ

Family and domain databases

Gene3Di3.40.50.11720, 1 hit
InterProiView protein in InterPro
IPR007507 Glycos_transf_N
IPR038107 Glycos_transf_N_sf
IPR005728 Rickett_RPE
PfamiView protein in Pfam
PF04413 Glycos_transf_N, 1 hit
TIGRFAMsiTIGR01045 RPE1, 1 hit

Sequencei

Sequence statusi: Complete.

Q92JE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLLYYALSF ILLPVYFIII LIRLLIGKED IRRIQERFAI GKHRQDDSLD
60 70 80 90 100
FMQTSANKEE FKGDTSLRTT TYTLIREDEG LGSTYKLPLE ASDARRLIWI
110 120 130 140 150
NAASIGESMV ALTLIHNISK RYPDVRFLVT SWTNSSAKIL TAKLPKIAVH
160 170 180 190 200
QFLPIDNIIF TRKFLRNWQP DLGIFIESEL WPCTINEGAK QCKLLLVNAR
210 220 230 240 250
ISDKSFKAWL QRKSFFQLIL KNCSKIIVQS ERDLQKFNEL GVSDAVNLGN
260 270 280 290 300
IKFANEKLPV NQEELSKLSL HLDNKRVVLF ASTHPEDEEV ILPIIKNLKE
310 320 330 340 350
QFLDCYIILI PRHPERVKSI IDNCKSHNLS ATAKSQNDLP VLSDDLYIVD
360 370 380 390 400
RFGEMGLFFS VATISFIGGS FKQGGHNILE AAYFSNCIIF GPDMSKNTDI
410 420 430 440 450
AKGVLQNEAA IQIKNGEDLL TKLTYLLRSN NALELTTYRE NALKFIKDNQ
460
KVLDEYLNVI TKFL
Length:464
Mass (Da):53,047
Last modified:December 1, 2001 - v1
Checksum:i476C023C396CFCFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA Translation: AAL02656.1
PIRiF97714
RefSeqiWP_010976798.1, NC_003103.1

Genome annotation databases

EnsemblBacteriaiAAL02656; AAL02656; RC0118
GeneIDi928074
KEGGirco:RC0118
PATRICifig|272944.4.peg.140

Similar proteinsi

Entry informationi

Entry nameiKDTA_RICCN
AccessioniPrimary (citable) accession number: Q92JE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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