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Q92JE7

- AAT_RICCN

UniProt

Q92JE7 - AAT_RICCN

Protein

Aspartate aminotransferase

Gene

aatA

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391Aspartate; via amide nitrogenBy similarity
    Binding sitei125 – 1251AspartateBy similarity
    Binding sitei175 – 1751AspartateBy similarity
    Binding sitei375 – 3751AspartateBy similarity

    GO - Molecular functioni

    1. L-aspartate:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
    2. L-phenylalanine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
    3. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartate aminotransferase (EC:2.6.1.1)
    Short name:
    AspAT
    Alternative name(s):
    Transaminase A
    Gene namesi
    Name:aatA
    Synonyms:aspC
    Ordered Locus Names:RC0120
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 401401Aspartate aminotransferasePRO_0000123850Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei239 – 2391N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi272944.RC0120.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92JE7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0436.
    HOGENOMiHOG000223062.
    KOiK00812.
    OMAiDFNTPEF.
    OrthoDBiEOG6RRKNS.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR004838. NHTrfase_class1_PyrdxlP-BS.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92JE7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIISTRLSS IKPSPTLAVV KKTLELKKAG VDIITLGAGE PDFDTPDNIK    50
    EGAIKAIKDG FTKYTNVEGM PLLKQAIKDK FKRENNIDYE LDEIIVSTGG 100
    KQVIYNLFMA SLDQGDEVII PAPYWVSYPD MVALSTGTPV FVNCGIENNF 150
    KLSAEALERS ITDKTKWLII NSPSNPTGAS YNFEELENIA KVLRKYSHVN 200
    VMSDDIYEHI TFDDFKFYTL AQIAPDLKKR IFTVNGVSKA YSMTGWRIGY 250
    GAGSKTLIKA MTIIQSQSTS NPCSISQMAA IEALNGPQDY IKPNALNCQK 300
    KRDLALSILK RVKYFECYKP EGAFYLFVKC DKIFGHKTKS GTIIANSNDF 350
    AEYLLEEAKV AVVPGIAFGL EGYFRISYAT SMEELEKACI RIEKTIDVIP 400
    A 401
    Length:401
    Mass (Da):44,576
    Last modified:December 1, 2001 - v1
    Checksum:i580494ECD865CF36
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02658.1.
    PIRiH97714.
    RefSeqiNP_359757.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL02658; AAL02658; RC0120.
    GeneIDi928075.
    KEGGirco:RC0120.
    PATRICi17887359. VBIRicCon45613_0142.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02658.1 .
    PIRi H97714.
    RefSeqi NP_359757.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92JE7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0120.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL02658 ; AAL02658 ; RC0120 .
    GeneIDi 928075.
    KEGGi rco:RC0120.
    PATRICi 17887359. VBIRicCon45613_0142.

    Phylogenomic databases

    eggNOGi COG0436.
    HOGENOMi HOG000223062.
    KOi K00812.
    OMAi DFNTPEF.
    OrthoDBi EOG6RRKNS.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR004838. NHTrfase_class1_PyrdxlP-BS.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00105. AA_TRANSFER_CLASS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiAAT_RICCN
    AccessioniPrimary (citable) accession number: Q92JE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 26, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia conorii
      (strain Malish 7): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3