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Q92JB1

- LEP_RICCN

UniProt

Q92JB1 - LEP_RICCN

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Protein
Signal peptidase I
Gene
lepB, RC0156
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451 By similarity
Active sitei108 – 1081 By similarity

GO - Molecular functioni

  1. serine-type peptidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal peptidase I (EC:3.4.21.89)
    Short name:
    SPase I
    Alternative name(s):
    Leader peptidase I
    Gene namesi
    Name:lepB
    Ordered Locus Names:RC0156
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei21 – 4121Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini42 – 266225Extracellular Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Signal peptidase I
    PRO_0000109515Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272944.RC0156.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92JB1.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S26 family.

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0681.
    HOGENOMiHOG000003673.
    KOiK03100.
    OMAiLYFWTWR.
    OrthoDBiEOG6KDKTM.

    Family and domain databases

    Gene3Di2.10.109.10. 2 hits.
    InterProiIPR000223. Pept_S26A_signal_pept_1.
    IPR019758. Pept_S26A_signal_pept_1_CS.
    IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
    IPR028360. Peptidase_S24/S26_b-rbn.
    IPR019759. Peptidase_S24_S26.
    IPR015927. Peptidase_S24_S26A/B/C.
    [Graphical view]
    PANTHERiPTHR12383. PTHR12383. 1 hit.
    PfamiPF00717. Peptidase_S24. 1 hit.
    [Graphical view]
    PRINTSiPR00727. LEADERPTASE.
    SUPFAMiSSF51306. SSF51306. 1 hit.
    TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.
    PROSITEiPS00760. SPASE_I_2. 1 hit.
    PS00761. SPASE_I_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92JB1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQTDNTKSNT NKTAKQEWGS FAFVICIALL IRILIMEPFN VPTGSMKATI    50
    LENDYIFSTK YSYGYSNYSL SFFDFIPLFK GRIFAREPDR GDIVVFRPPN 100
    DMSVRYIKRL IGLPGDKIQL IDDVIYINDK KIERTEVGTY ISEEGIKYLK 150
    FKETLPNGRT YFSYKLAPIY GVIYNDRYSN TDVFYVPEGQ YFFLGDNRDQ 200
    SNDSRVNLGF VPFENFIAKA QFIWFSTKIT WWDNDIGVIN LVLKLKPWIE 250
    SVRLNRIFRN LYNTDA 266
    Length:266
    Mass (Da):31,140
    Last modified:December 1, 2001 - v1
    Checksum:i7C3926FECAB482FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02694.1.
    PIRiD97719.
    RefSeqiNP_359793.1. NC_003103.1.
    WP_010976832.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL02694; AAL02694; RC0156.
    GeneIDi928036.
    KEGGirco:RC0156.
    PATRICi17887447. VBIRicCon45613_0185.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02694.1 .
    PIRi D97719.
    RefSeqi NP_359793.1. NC_003103.1.
    WP_010976832.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92JB1.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0156.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL02694 ; AAL02694 ; RC0156 .
    GeneIDi 928036.
    KEGGi rco:RC0156.
    PATRICi 17887447. VBIRicCon45613_0185.

    Phylogenomic databases

    eggNOGi COG0681.
    HOGENOMi HOG000003673.
    KOi K03100.
    OMAi LYFWTWR.
    OrthoDBi EOG6KDKTM.

    Family and domain databases

    Gene3Di 2.10.109.10. 2 hits.
    InterProi IPR000223. Pept_S26A_signal_pept_1.
    IPR019758. Pept_S26A_signal_pept_1_CS.
    IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
    IPR028360. Peptidase_S24/S26_b-rbn.
    IPR019759. Peptidase_S24_S26.
    IPR015927. Peptidase_S24_S26A/B/C.
    [Graphical view ]
    PANTHERi PTHR12383. PTHR12383. 1 hit.
    Pfami PF00717. Peptidase_S24. 1 hit.
    [Graphical view ]
    PRINTSi PR00727. LEADERPTASE.
    SUPFAMi SSF51306. SSF51306. 1 hit.
    TIGRFAMsi TIGR02227. sigpep_I_bact. 1 hit.
    PROSITEi PS00760. SPASE_I_2. 1 hit.
    PS00761. SPASE_I_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiLEP_RICCN
    AccessioniPrimary (citable) accession number: Q92JB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: December 1, 2001
    Last modified: September 3, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Rickettsia conorii
      (strain Malish 7): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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