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Reviewed, UniProtKB/Swiss-Prot Q92JB1 (LEP_RICCN)

Last modified November 3, 2009. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Signal peptidase I
      Short name=SPase I
    EC=3.4.21.89
Alternative name(s):
    Leader peptidase I
Gene names
Name: lepB
Ordered Locus Names: RC0156
OrganismRickettsia conorii [Complete proteome] [HAMAP]
Taxonomic identifier781 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Subcellular location

Cell membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the peptidase S26 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   Molecular functionHydrolase
Protease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionserine-type peptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Signal peptidase I
PRO_0000109515

Regions

Topological domain1 – 2020Cytoplasmic Potential
Transmembrane21 – 4121 Potential
Topological domain42 – 266225Extracellular Potential

Sites

Active site451 By similarity
Active site1081 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92JB1-1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 7C3926FECAB482FA

FASTA26631,140
        10         20         30         40         50         60 
MQTDNTKSNT NKTAKQEWGS FAFVICIALL IRILIMEPFN VPTGSMKATI LENDYIFSTK 

        70         80         90        100        110        120 
YSYGYSNYSL SFFDFIPLFK GRIFAREPDR GDIVVFRPPN DMSVRYIKRL IGLPGDKIQL 

       130        140        150        160        170        180 
IDDVIYINDK KIERTEVGTY ISEEGIKYLK FKETLPNGRT YFSYKLAPIY GVIYNDRYSN 

       190        200        210        220        230        240 
TDVFYVPEGQ YFFLGDNRDQ SNDSRVNLGF VPFENFIAKA QFIWFSTKIT WWDNDIGVIN 

       250        260 
LVLKLKPWIE SVRLNRIFRN LYNTDA 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

AE006914 Genomic DNA. Translation: AAL02694.1.
PIRD97719.
RefSeqNP_359793.1.

3D structure databases

HSSPHSSP built from PDB template 1B12 based on UniProtKB P00803.
ModBaseSearch...

Protein family/group databases

MEROPSS26.001.

Genome annotation databases

GeneID928036.
GenomeReviewsGene locus RC0156 in contig AE006914_GR.
KEGGrco:RC0156.
NMPDRfig|272944.1.peg.156.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ92JB1.
OMAKPWIESV.

Enzyme and pathway databases

BioCycRCON272944:RC0156-MON.
BRENDA3.4.21.89. 267518.

Family and domain databases

InterProIPR000223. Pept_S26A_signal_pept_1.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR019759. Peptidase_S24_S26_cons-reg.
IPR011056. Peptidase_S24_S26A/B/C_b-rbn.
[Graphical view]
Gene3DG3DSA:2.10.109.10. Pept_S24_S26_C. 1 hit.
PfamPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSPR00727. LEADERPTASE.
TIGRFAMsTIGR02227. sigpep_I_bact. 1 hit.
PROSITEPS00501. SPASE_I_1. False negative.
PS00760. SPASE_I_2. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLEP_RICCN
AccessionPrimary (citable) accession number: Q92JB1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: December 1, 2001
Last modified: November 3, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

Rickettsia conorii

(strain Malish 7): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents