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Protein

GTPase Era

Gene

era

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi59 – 668GTPUniRule annotation
Nucleotide bindingi106 – 1105GTPUniRule annotation
Nucleotide bindingi168 – 1714GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-HAMAP
  3. small ribosomal subunit rRNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. ribosomal small subunit biogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase EraUniRule annotation
Gene namesi
Name:eraUniRule annotation
Ordered Locus Names:RC0158
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

Subcellular locationi

Cytoplasm. Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339GTPase EraPRO_0000180042Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi272944.RC0158.

Structurei

3D structure databases

ProteinModelPortaliQ92JA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 4845RPE1 insertAdd
BLAST
Domaini51 – 220170Era-type GAdd
BLAST
Domaini248 – 32578KH type-2UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.UniRule annotation
Contains 1 KH type-2 domain.UniRule annotation
Contains 1 RPE1 insert domain.Curated

Phylogenomic databases

eggNOGiCOG1159.
HOGENOMiHOG000245597.
KOiK03595.
OMAiKAKISPW.
OrthoDBiEOG68DD1Q.

Family and domain databases

Gene3Di3.30.300.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00367. GTPase_Era.
InterProiIPR030388. G_ERA_dom.
IPR005662. GTP-bd_Era.
IPR006073. GTP_binding_domain.
IPR015946. KH_dom-like_a/b.
IPR004044. KH_dom_type_2.
IPR009019. KH_prok-type.
IPR027417. P-loop_NTPase.
IPR005728. Rickett_RPE.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PfamiPF07650. KH_2. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54814. SSF54814. 1 hit.
TIGRFAMsiTIGR00436. era. 1 hit.
TIGR01045. RPE1. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51713. G_ERA. 1 hit.
PS50823. KH_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92JA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNRHLAKFA YREEFKGDTE ALAAAVREDA STGSTSQLPL EVQFGKMSNQ
60 70 80 90 100
KTVSVCIIGR PNSGKSTLLN RIIGEKLSIV TPKVQTTRSI ITGIITLKDT
110 120 130 140 150
QVILYDTPGI FEPKGSLEKA MVRCAWSSLH SADLVLLIID SLKSFDDITH
160 170 180 190 200
NIVDKLRSLN IVPIFLLNKI DIESKYLNDI KAFLTENHPD SLLFPISALS
210 220 230 240 250
GKNIDGLLEY ITSKAKISPW LYAEDDITDL PMRFIAAEIT REQLFLNLQK
260 270 280 290 300
ELPYKLTVQT EKWEDLKDKS VKINQVIVVS RESYKTIILG KNGSKIKEIG
310 320 330
AKSRMQMERF FGFPVHLFLF VKVRELWENN QEFYQYMKI
Length:339
Mass (Da):38,582
Last modified:December 1, 2001 - v1
Checksum:i9378BCB362B8A62D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL02696.1.
PIRiF97719.
RefSeqiNP_359795.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL02696; AAL02696; RC0158.
GeneIDi928031.
KEGGirco:RC0158.
PATRICi17887451. VBIRicCon45613_0187.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL02696.1.
PIRiF97719.
RefSeqiNP_359795.1. NC_003103.1.

3D structure databases

ProteinModelPortaliQ92JA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272944.RC0158.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL02696; AAL02696; RC0158.
GeneIDi928031.
KEGGirco:RC0158.
PATRICi17887451. VBIRicCon45613_0187.

Phylogenomic databases

eggNOGiCOG1159.
HOGENOMiHOG000245597.
KOiK03595.
OMAiKAKISPW.
OrthoDBiEOG68DD1Q.

Family and domain databases

Gene3Di3.30.300.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00367. GTPase_Era.
InterProiIPR030388. G_ERA_dom.
IPR005662. GTP-bd_Era.
IPR006073. GTP_binding_domain.
IPR015946. KH_dom-like_a/b.
IPR004044. KH_dom_type_2.
IPR009019. KH_prok-type.
IPR027417. P-loop_NTPase.
IPR005728. Rickett_RPE.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PfamiPF07650. KH_2. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54814. SSF54814. 1 hit.
TIGRFAMsiTIGR00436. era. 1 hit.
TIGR01045. RPE1. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51713. G_ERA. 1 hit.
PS50823. KH_TYPE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiERA_RICCN
AccessioniPrimary (citable) accession number: Q92JA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: December 1, 2001
Last modified: March 4, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.