Q92JA9 (ERA_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTPase Era

Gene names

Name:	era
Ordered Locus Names:	RC0158

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia conorii

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism By similarity. HAMAP-Rule MF_00367
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm. Cell inner membrane; Peripheral membrane protein By similarity HAMAP-Rule MF_00367.
Sequence similarities	Belongs to the Era/MnmE GTP-binding protein family. Era subfamily. Contains 1 G (guanine nucleotide-binding) domain. Contains 1 KH type-2 domain. Contains 1 RPE1 insert domain.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Cytoplasm Membrane
Ligand	GTP-binding Nucleotide-binding RNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	GTP catabolic process Inferred from electronic annotation. Source: GOC ribosomal small subunit biogenesis Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: HAMAP GTPase activity Inferred from electronic annotation. Source: HAMAP SSU rRNA binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	GTPase Era HAMAP-Rule MF_00367		PRO_0000180042
Regions
	Domain	4 – 48	45	RPE1 insert
	Domain	64 – 169	106	G
	Domain	248 – 325	78	KH type-2
	Nucleotide binding	59 – 66	8	GTP Potential
	Nucleotide binding	106 – 110	5	GTP Potential
	Nucleotide binding	168 – 171	4	GTP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q92JA9 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 9378BCB362B8A62D	FASTA	339	38,582
	10 20 30 40 50 60 MTNRHLAKFA YREEFKGDTE ALAAAVREDA STGSTSQLPL EVQFGKMSNQ KTVSVCIIGR 70 80 90 100 110 120 PNSGKSTLLN RIIGEKLSIV TPKVQTTRSI ITGIITLKDT QVILYDTPGI FEPKGSLEKA 130 140 150 160 170 180 MVRCAWSSLH SADLVLLIID SLKSFDDITH NIVDKLRSLN IVPIFLLNKI DIESKYLNDI 190 200 210 220 230 240 KAFLTENHPD SLLFPISALS GKNIDGLLEY ITSKAKISPW LYAEDDITDL PMRFIAAEIT 250 260 270 280 290 300 REQLFLNLQK ELPYKLTVQT EKWEDLKDKS VKINQVIVVS RESYKTIILG KNGSKIKEIG 310 320 330 AKSRMQMERF FGFPVHLFLF VKVRELWENN QEFYQYMKI

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL02696.1.
PIR	F97719.
RefSeq	NP_359795.1. NC_003103.1.
3D structure databases
ProteinModelPortal	Q92JA9.
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC0158.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL02696; AAL02696; RC0158.
GeneID	928031.
KEGG	rco:RC0158.
PATRIC	17887451. VBIRicCon45613_0187.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1159.
HOGENOM	HOG000245597.
KO	K03595.
OMA	ITREQLF.
ProtClustDB	PRK15494.
Family and domain databases
Gene3D	3.30.300.20. 1 hit.
HAMAP	MF_00367. GTPase_Era. Divergent sequence.
InterPro	IPR005662. GTP-bd_Era. IPR006073. GTP_binding_domain. IPR015946. KH_dom-like_a/b. IPR004044. KH_dom_type_2. IPR009019. KH_prok-type. IPR005728. Rickett_RPE. IPR005225. Small_GTP-bd_dom. [Graphical view]
Pfam	PF07650. KH_2. 1 hit. PF01926. MMR_HSR1. 1 hit. [Graphical view]
SUPFAM	SSF54814. KH_prok. 1 hit.
TIGRFAMs	TIGR00436. era. 1 hit. TIGR01045. RPE1. 1 hit. TIGR00231. small_GTP. 1 hit.
PROSITE	PS50823. KH_TYPE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ERA_RICCN

Accession

Primary (citable) accession number: Q92JA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program