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Q92JA9 (ERA_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTPase Era
Gene names
Name:era
Ordered Locus Names:RC0158
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism By similarity. HAMAP-Rule MF_00367

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00367

Subcellular location

Cytoplasm. Cell inner membrane; Peripheral membrane protein By similarity HAMAP-Rule MF_00367.

Sequence similarities

Belongs to the Era/MnmE GTP-binding protein family. Era subfamily.

Contains 1 G (guanine nucleotide-binding) domain.

Contains 1 KH type-2 domain.

Contains 1 RPE1 insert domain.

Ontologies

Keywords
   Cellular componentCell inner membrane
Cell membrane
Cytoplasm
Membrane
   LigandGTP-binding
Nucleotide-binding
RNA-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processribosomal small subunit biogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

SSU rRNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339GTPase Era HAMAP-Rule MF_00367
PRO_0000180042

Regions

Domain4 – 4845RPE1 insert
Domain64 – 169106G
Domain248 – 32578KH type-2
Nucleotide binding59 – 668GTP Potential
Nucleotide binding106 – 1105GTP Potential
Nucleotide binding168 – 1714GTP Potential

Sequences

Sequence LengthMass (Da)Tools
Q92JA9 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 9378BCB362B8A62D

FASTA33938,582
        10         20         30         40         50         60 
MTNRHLAKFA YREEFKGDTE ALAAAVREDA STGSTSQLPL EVQFGKMSNQ KTVSVCIIGR 

        70         80         90        100        110        120 
PNSGKSTLLN RIIGEKLSIV TPKVQTTRSI ITGIITLKDT QVILYDTPGI FEPKGSLEKA 

       130        140        150        160        170        180 
MVRCAWSSLH SADLVLLIID SLKSFDDITH NIVDKLRSLN IVPIFLLNKI DIESKYLNDI 

       190        200        210        220        230        240 
KAFLTENHPD SLLFPISALS GKNIDGLLEY ITSKAKISPW LYAEDDITDL PMRFIAAEIT 

       250        260        270        280        290        300 
REQLFLNLQK ELPYKLTVQT EKWEDLKDKS VKINQVIVVS RESYKTIILG KNGSKIKEIG 

       310        320        330 
AKSRMQMERF FGFPVHLFLF VKVRELWENN QEFYQYMKI 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL02696.1.
PIRF97719.
RefSeqNP_359795.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92JA9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC0158.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL02696; AAL02696; RC0158.
GeneID928031.
KEGGrco:RC0158.
PATRIC17887451. VBIRicCon45613_0187.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1159.
HOGENOMHOG000245597.
KOK03595.
OMARCAWSSL.
OrthoDBEOG68DD1Q.
ProtClustDBPRK15494.

Family and domain databases

Gene3D3.30.300.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00367. GTPase_Era.
InterProIPR005662. GTP-bd_Era.
IPR006073. GTP_binding_domain.
IPR015946. KH_dom-like_a/b.
IPR004044. KH_dom_type_2.
IPR009019. KH_prok-type.
IPR027417. P-loop_NTPase.
IPR005728. Rickett_RPE.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PfamPF07650. KH_2. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
SSF54814. SSF54814. 1 hit.
TIGRFAMsTIGR00436. era. 1 hit.
TIGR01045. RPE1. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS50823. KH_TYPE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameERA_RICCN
AccessionPrimary (citable) accession number: Q92JA9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names