Q92J98 (DHSD_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Succinate dehydrogenase hydrophobic membrane anchor subunit

Gene names

Name:	sdhD
Ordered Locus Names:	RC0169

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia conorii

Protein attributes

Sequence length	126 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Membrane-anchoring subunit of succinate dehydrogenase (SDH) By similarity.
Cofactor	Heme group. The heme is bound between the two transmembrane subunits By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle.
Subunit structure	Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein.

Ontologies

Keywords
Biological process	Electron transport Transport Tricarboxylic acid cycle
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	heme binding Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW succinate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 126	126	Succinate dehydrogenase hydrophobic membrane anchor subunit		PRO_0000158677
Regions
	Topological domain	1 – 24	24	Cytoplasmic By similarity
	Transmembrane	25 – 45	21	Helical; By similarity
	Topological domain	46 – 68	23	Periplasmic By similarity
	Transmembrane	69 – 90	22	Helical; By similarity
	Topological domain	91 – 100	10	Cytoplasmic By similarity
	Transmembrane	101 – 124	24	Helical; By similarity
Sites
	Metal binding	81	1	Iron (heme axial ligand); shared with second transmembrane subunit By similarity
	Binding site	93	1	Ubiquinone By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92J98 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 72B93A63BF0B2C13	FASTA	126	14,403
	10 20 30 40 50 60 MVYDFKAEIV KAKNSGSAKS GSHHWLLQRV TGIILALCSV WLIYFTLTNK NNDINIIMLW 70 80 90 100 110 120 ELKKPFNVVA LLITVVISLY HAMLGMRVVI EDYISYHKLR NTLIIIVQLF CIVTIVAFVV ALFYKG

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL02707.1.
PIR	A97721.
RefSeq	NP_359806.1. NC_003103.1.
3D structure databases
ProteinModelPortal	Q92J98.
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC0169.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL02707; AAL02707; RC0169.
GeneID	928022.
KEGG	rco:RC0169.
PATRIC	17887473. VBIRicCon45613_0198.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2142.
HOGENOM	HOG000139244.
KO	K00242.
OMA	INIIMWE.
ProtClustDB	CLSK870758.
Enzyme and pathway databases
UniPathway	UPA00223.
Family and domain databases
InterPro	IPR014312. Succ_DH_anchor. IPR000701. Succ_DH_Fumarate_Rdtase_TM-su. [Graphical view]
Pfam	PF01127. Sdh_cyt. 1 hit. [Graphical view]
TIGRFAMs	TIGR02968. succ_dehyd_anc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DHSD_RICCN

Accession

Primary (citable) accession number: Q92J98

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program