Q92J93 (EFG_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Elongation factor G
Short name=EF-G

Gene names

Name:	fusA
Ordered Locus Names:	RC0174

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia conorii

Protein attributes

Sequence length	699 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome By similarity. HAMAP-Rule MF_00054
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Elongation factor
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	GTP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: HAMAP GTPase activity Inferred from electronic annotation. Source: InterPro translation elongation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 699	699	Elongation factor G HAMAP-Rule MF_00054		PRO_0000091196
Regions
	Nucleotide binding	17 – 24	8	GTP By similarity
	Nucleotide binding	81 – 85	5	GTP By similarity
	Nucleotide binding	135 – 138	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92J93 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: C51222EB05D0CE54	FASTA	699	77,708
	10 20 30 40 50 60 MSKINKLEHI RNIGICAHID AGKTTTTERI LYYTGKSHKI GEVHEGGATM DWMEQEQERG 70 80 90 100 110 120 ITITSAATTC RWQDKIINII DTPGHVDFTI EVERSLRVLD GAVAVFDGVA GVEPQSETVW 130 140 150 160 170 180 RQADKYNVPR MCFVNKMDRM GADFYRCVEM LKDRLGAKPL VIQLPVGIEE NFKGIIDLIK 190 200 210 220 230 240 MKAVIWKDEA LGAEYFEEDI PADMKDKAEE YRAKLLDMVV ELDDHVMEKY LSGEEVTAEE 250 260 270 280 290 300 IKRLIRKGTI SAAFYPVLCG SAFKNKGVQP LLDAVVDFLP SPIDIGIVKG MEVSTGEEKD 310 320 330 340 350 360 FPISVTEPFA ALAFKIMNDP FVGSLTFIRI YSGKITSGTT VINTVKNKRE KIGRMLLMHA 370 380 390 400 410 420 NNREDVKEAS AGDIVALAGL KDTTTGDTLS DIDQQVILER MEFPEPVIEL AVEPKSTADQ 430 440 450 460 470 480 EKMGLALSRL AAEDPSFRVS TDYETGQTVI KGMGELHLEI IIDRMRREFK VEANIGAPQV 490 500 510 520 530 540 AYRETITKVC EIDYTHKKQS GGAGQFARVK IIFEPLKEVK DLKDEDKNKI FVFESKIIGG 550 560 570 580 590 600 AVPKEYIPGV EKGLNNIRET GVIAGYPMID FKATLVDGAF HDVDSSVLAF EIAAKAAFRE 610 620 630 640 650 660 GMPKGNPKLL EPIMQVEVIT PDEYMGDIIG DLNSRRGQIQ SMDPRGNAQV VTANVPLAEM 670 680 690 FGYVNTLRSL SQGRAQFSMI FSHYDQVPSQ VADIIKAKK

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL02712.1.
PIR	F97721.
RefSeq	NP_359811.1. NC_003103.1.
3D structure databases
ProteinModelPortal	Q92J93.
SMR	Q92J93. Positions 5-694.
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC0174.
Proteomic databases
PRIDE	Q92J93.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL02712; AAL02712; RC0174.
GeneID	928019.
KEGG	rco:RC0174.
PATRIC	17887483. VBIRicCon45613_0203.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0480.
HOGENOM	HOG000231585.
KO	K02355.
OMA	RKATINM.
ProtClustDB	PRK12739.
Family and domain databases
Gene3D	3.30.230.10. 1 hit. 3.30.70.240. 1 hit.
HAMAP	MF_00054_B. EF-G_EF-2_B.
InterPro	IPR000795. EF_GTP-bd_dom. IPR009022. EFG_III-V. IPR000640. EFG_V. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR005225. Small_GTP-bd_dom. IPR004540. Transl_elong_EFG/EF2. IPR005517. Transl_elong_EFG/EF2_IV. IPR004161. Transl_elong_EFTu/EF1A_2. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Pfam	PF00679. EFG_C. 1 hit. PF03764. EFG_IV. 1 hit. PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SMART	SM00838. EFG_C. 1 hit. SM00889. EFG_IV. 1 hit. [Graphical view]
SUPFAM	SSF54980. EFG_III_V. 2 hits. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit. SSF50447. Translat_factor. 1 hit.
TIGRFAMs	TIGR00484. EF-G. 1 hit. TIGR00231. small_GTP. 1 hit.
PROSITE	PS00301. EFACTOR_GTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EFG_RICCN

Accession

Primary (citable) accession number: Q92J93

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program