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Q92J93 (EFG_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Elongation factor G

Short name=EF-G
Gene names
Name:fusA
Ordered Locus Names:RC0174
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length699 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome By similarity. HAMAP-Rule MF_00054

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00054.

Sequence similarities

Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionElongation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

GTPase activity

Inferred from electronic annotation. Source: InterPro

translation elongation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 699699Elongation factor G HAMAP-Rule MF_00054
PRO_0000091196

Regions

Nucleotide binding17 – 248GTP By similarity
Nucleotide binding81 – 855GTP By similarity
Nucleotide binding135 – 1384GTP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92J93 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: C51222EB05D0CE54

FASTA69977,708
        10         20         30         40         50         60 
MSKINKLEHI RNIGICAHID AGKTTTTERI LYYTGKSHKI GEVHEGGATM DWMEQEQERG 

        70         80         90        100        110        120 
ITITSAATTC RWQDKIINII DTPGHVDFTI EVERSLRVLD GAVAVFDGVA GVEPQSETVW 

       130        140        150        160        170        180 
RQADKYNVPR MCFVNKMDRM GADFYRCVEM LKDRLGAKPL VIQLPVGIEE NFKGIIDLIK 

       190        200        210        220        230        240 
MKAVIWKDEA LGAEYFEEDI PADMKDKAEE YRAKLLDMVV ELDDHVMEKY LSGEEVTAEE 

       250        260        270        280        290        300 
IKRLIRKGTI SAAFYPVLCG SAFKNKGVQP LLDAVVDFLP SPIDIGIVKG MEVSTGEEKD 

       310        320        330        340        350        360 
FPISVTEPFA ALAFKIMNDP FVGSLTFIRI YSGKITSGTT VINTVKNKRE KIGRMLLMHA 

       370        380        390        400        410        420 
NNREDVKEAS AGDIVALAGL KDTTTGDTLS DIDQQVILER MEFPEPVIEL AVEPKSTADQ 

       430        440        450        460        470        480 
EKMGLALSRL AAEDPSFRVS TDYETGQTVI KGMGELHLEI IIDRMRREFK VEANIGAPQV 

       490        500        510        520        530        540 
AYRETITKVC EIDYTHKKQS GGAGQFARVK IIFEPLKEVK DLKDEDKNKI FVFESKIIGG 

       550        560        570        580        590        600 
AVPKEYIPGV EKGLNNIRET GVIAGYPMID FKATLVDGAF HDVDSSVLAF EIAAKAAFRE 

       610        620        630        640        650        660 
GMPKGNPKLL EPIMQVEVIT PDEYMGDIIG DLNSRRGQIQ SMDPRGNAQV VTANVPLAEM 

       670        680        690 
FGYVNTLRSL SQGRAQFSMI FSHYDQVPSQ VADIIKAKK 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL02712.1.
PIRF97721.
RefSeqNP_359811.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92J93.
SMRQ92J93. Positions 5-694.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC0174.

Proteomic databases

PRIDEQ92J93.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL02712; AAL02712; RC0174.
GeneID928019.
KEGGrco:RC0174.
PATRIC17887483. VBIRicCon45613_0203.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0480.
HOGENOMHOG000231585.
KOK02355.
OMAEYIPSCD.
OrthoDBEOG6X6RBF.
ProtClustDBPRK12739.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00054_B. EF_G_EF_2_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSPR00315. ELONGATNFCT.
SMARTSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsTIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEFG_RICCN
AccessionPrimary (citable) accession number: Q92J93
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names