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Q92J42

- ODO1_RICCN

UniProt

Q92J42 - ODO1_RICCN

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Protein

2-oxoglutarate dehydrogenase E1 component

Gene
sucA, RC0227
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Ordered Locus Names:RC0227
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9289282-oxoglutarate dehydrogenase E1 componentPRO_0000162195Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi272944.RC0227.

Structurei

3D structure databases

ProteinModelPortaliQ92J42.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiGHQNANL.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92J42-1 [UniParc]FASTAAdd to Basket

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MGEDFKKTGY LFGGNAVFVE ELYKQYLANP ASVDQTWQEF FAGIKDNNTL    50
LNKSTAKIII PDEIKKESLN NNLSSEDLNS LKAKEMINAY RKHAHYLANL 100
DPLGLELRKT KNDLKLNIET FGLDSGQLEE NINITDEFVG TWNCKLSELV 150
TKFDKVYTGS IGVEFEQIEN VAGKNWLYNK LESEVTFSSE DKKTILNDLV 200
EVEGFEQYLH TKFPGAKRFS IEGGDASIVA MSKAIDLSMH QGVSEIVIGM 250
AHRGRLNTLT KVVGKPYKAV IADFISGSVF PDELNVSGDV KYHLGYSSDR 300
TLEDKKIHLS LADNPSHLEA VNPIVAGKVR AKQDILGDTK RSKVKAILVH 350
GDAAFCGQGV VAESLSMSPL AAYDIGGILH FVINNQLGFT ANAADTRASR 400
YSTEFAKIIA APILHVNGDD IEAVLKATNI AVEYRQKFGK DVVVEIICYR 450
KYGHNEGDEP MYTQGKMYNI IKNKLTPGNI YANELVKSGV IDNNYFAKLK 500
EEFKAKLDKE YEQAKSYKQE AHFLGGLWQG ISRTRTQATI TGISKKTLHD 550
LGTKLCEIPK DFAVNPKLVK LFEARKATLT ADQPIDWATA EQLAFASLLA 600
SGTNIRLTGQ DSGRGTFSHR HSVLHNQIDG TTYIPLNNLS KEQAKYEVAD 650
SNLSEYAVLG FEYGYSLANP KNLVLWEAQF GDFANGAQII FDQFISSSET 700
KWLRMSGLVV LLPHAFEGQG PEHSSARLER FLQLAAENNM YVTYPTTPAS 750
IFHLLRRQIL DDTRKPLIVM SPKSLLRHKY AVSKLDELGE NTTFLPVLDE 800
VTKVDTNNIT KVILCSGKVY YDLFEMRGNN SNIAIIRLEQ LYPFEKKLVA 850
SLLKKYNRTQ EFIWCQEEPK NMGTWCYIVS HLNDALKEAG IKNEFKYVGR 900
EESASPAVGS LQVHNKQQEK LLRTALGI 928
Length:928
Mass (Da):103,801
Last modified:December 1, 2001 - v1
Checksum:i4468B7CE1901591D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL02765.1.
PIRiC97728.
RefSeqiNP_359864.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL02765; AAL02765; RC0227.
GeneIDi927961.
KEGGirco:RC0227.
PATRICi17887605. VBIRicCon45613_0262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL02765.1 .
PIRi C97728.
RefSeqi NP_359864.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92J42.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC0227.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL02765 ; AAL02765 ; RC0227 .
GeneIDi 927961.
KEGGi rco:RC0227.
PATRICi 17887605. VBIRicCon45613_0262.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi GHQNANL.
OrthoDBi EOG6V1M1F.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiODO1_RICCN
AccessioniPrimary (citable) accession number: Q92J42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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