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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

sucA

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandThiamine pyrophosphate

Enzyme and pathway databases

BioCyciRCON272944:G1FZG-383-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Ordered Locus Names:RC0227
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001621951 – 9282-oxoglutarate dehydrogenase E1 componentAdd BLAST928

Proteomic databases

PRIDEiQ92J42

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ92J42
SMRiQ92J42
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000259588
KOiK00164
OMAiIDMVCYR
OrthoDBiPOG091H03SK

Family and domain databases

InterProiView protein in InterPro
IPR032106 2-oxogl_dehyd_N
IPR011603 2oxoglutarate_DH_E1
IPR001017 DH_E1
IPR031717 KGD_C
IPR029061 THDP-binding
IPR005475 Transketolase-like_Pyr-bd
PANTHERiPTHR23152 PTHR23152, 1 hit
PfamiView protein in Pfam
PF16078 2-oxogl_dehyd_N, 1 hit
PF00676 E1_dh, 1 hit
PF16870 OxoGdeHyase_C, 1 hit
PF02779 Transket_pyr, 1 hit
PIRSFiPIRSF000157 Oxoglu_dh_E1, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
TIGRFAMsiTIGR00239 2oxo_dh_E1, 1 hit

Sequencei

Sequence statusi: Complete.

Q92J42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEDFKKTGY LFGGNAVFVE ELYKQYLANP ASVDQTWQEF FAGIKDNNTL
60 70 80 90 100
LNKSTAKIII PDEIKKESLN NNLSSEDLNS LKAKEMINAY RKHAHYLANL
110 120 130 140 150
DPLGLELRKT KNDLKLNIET FGLDSGQLEE NINITDEFVG TWNCKLSELV
160 170 180 190 200
TKFDKVYTGS IGVEFEQIEN VAGKNWLYNK LESEVTFSSE DKKTILNDLV
210 220 230 240 250
EVEGFEQYLH TKFPGAKRFS IEGGDASIVA MSKAIDLSMH QGVSEIVIGM
260 270 280 290 300
AHRGRLNTLT KVVGKPYKAV IADFISGSVF PDELNVSGDV KYHLGYSSDR
310 320 330 340 350
TLEDKKIHLS LADNPSHLEA VNPIVAGKVR AKQDILGDTK RSKVKAILVH
360 370 380 390 400
GDAAFCGQGV VAESLSMSPL AAYDIGGILH FVINNQLGFT ANAADTRASR
410 420 430 440 450
YSTEFAKIIA APILHVNGDD IEAVLKATNI AVEYRQKFGK DVVVEIICYR
460 470 480 490 500
KYGHNEGDEP MYTQGKMYNI IKNKLTPGNI YANELVKSGV IDNNYFAKLK
510 520 530 540 550
EEFKAKLDKE YEQAKSYKQE AHFLGGLWQG ISRTRTQATI TGISKKTLHD
560 570 580 590 600
LGTKLCEIPK DFAVNPKLVK LFEARKATLT ADQPIDWATA EQLAFASLLA
610 620 630 640 650
SGTNIRLTGQ DSGRGTFSHR HSVLHNQIDG TTYIPLNNLS KEQAKYEVAD
660 670 680 690 700
SNLSEYAVLG FEYGYSLANP KNLVLWEAQF GDFANGAQII FDQFISSSET
710 720 730 740 750
KWLRMSGLVV LLPHAFEGQG PEHSSARLER FLQLAAENNM YVTYPTTPAS
760 770 780 790 800
IFHLLRRQIL DDTRKPLIVM SPKSLLRHKY AVSKLDELGE NTTFLPVLDE
810 820 830 840 850
VTKVDTNNIT KVILCSGKVY YDLFEMRGNN SNIAIIRLEQ LYPFEKKLVA
860 870 880 890 900
SLLKKYNRTQ EFIWCQEEPK NMGTWCYIVS HLNDALKEAG IKNEFKYVGR
910 920
EESASPAVGS LQVHNKQQEK LLRTALGI
Length:928
Mass (Da):103,801
Last modified:December 1, 2001 - v1
Checksum:i4468B7CE1901591D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA Translation: AAL02765.1
PIRiC97728
RefSeqiWP_010976891.1, NC_003103.1

Genome annotation databases

EnsemblBacteriaiAAL02765; AAL02765; RC0227
GeneIDi927961
KEGGirco:RC0227
PATRICifig|272944.4.peg.262

Similar proteinsi

Entry informationi

Entry nameiODO1_RICCN
AccessioniPrimary (citable) accession number: Q92J42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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