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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

sucA

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Ordered Locus Names:RC0227
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9289282-oxoglutarate dehydrogenase E1 componentPRO_0000162195Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272944.RC0227.

Structurei

3D structure databases

ProteinModelPortaliQ92J42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiQNQGAWF.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92J42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEDFKKTGY LFGGNAVFVE ELYKQYLANP ASVDQTWQEF FAGIKDNNTL
60 70 80 90 100
LNKSTAKIII PDEIKKESLN NNLSSEDLNS LKAKEMINAY RKHAHYLANL
110 120 130 140 150
DPLGLELRKT KNDLKLNIET FGLDSGQLEE NINITDEFVG TWNCKLSELV
160 170 180 190 200
TKFDKVYTGS IGVEFEQIEN VAGKNWLYNK LESEVTFSSE DKKTILNDLV
210 220 230 240 250
EVEGFEQYLH TKFPGAKRFS IEGGDASIVA MSKAIDLSMH QGVSEIVIGM
260 270 280 290 300
AHRGRLNTLT KVVGKPYKAV IADFISGSVF PDELNVSGDV KYHLGYSSDR
310 320 330 340 350
TLEDKKIHLS LADNPSHLEA VNPIVAGKVR AKQDILGDTK RSKVKAILVH
360 370 380 390 400
GDAAFCGQGV VAESLSMSPL AAYDIGGILH FVINNQLGFT ANAADTRASR
410 420 430 440 450
YSTEFAKIIA APILHVNGDD IEAVLKATNI AVEYRQKFGK DVVVEIICYR
460 470 480 490 500
KYGHNEGDEP MYTQGKMYNI IKNKLTPGNI YANELVKSGV IDNNYFAKLK
510 520 530 540 550
EEFKAKLDKE YEQAKSYKQE AHFLGGLWQG ISRTRTQATI TGISKKTLHD
560 570 580 590 600
LGTKLCEIPK DFAVNPKLVK LFEARKATLT ADQPIDWATA EQLAFASLLA
610 620 630 640 650
SGTNIRLTGQ DSGRGTFSHR HSVLHNQIDG TTYIPLNNLS KEQAKYEVAD
660 670 680 690 700
SNLSEYAVLG FEYGYSLANP KNLVLWEAQF GDFANGAQII FDQFISSSET
710 720 730 740 750
KWLRMSGLVV LLPHAFEGQG PEHSSARLER FLQLAAENNM YVTYPTTPAS
760 770 780 790 800
IFHLLRRQIL DDTRKPLIVM SPKSLLRHKY AVSKLDELGE NTTFLPVLDE
810 820 830 840 850
VTKVDTNNIT KVILCSGKVY YDLFEMRGNN SNIAIIRLEQ LYPFEKKLVA
860 870 880 890 900
SLLKKYNRTQ EFIWCQEEPK NMGTWCYIVS HLNDALKEAG IKNEFKYVGR
910 920
EESASPAVGS LQVHNKQQEK LLRTALGI
Length:928
Mass (Da):103,801
Last modified:December 1, 2001 - v1
Checksum:i4468B7CE1901591D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL02765.1.
PIRiC97728.
RefSeqiNP_359864.1. NC_003103.1.
WP_010976891.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL02765; AAL02765; RC0227.
GeneIDi927961.
KEGGirco:RC0227.
PATRICi17887605. VBIRicCon45613_0262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL02765.1.
PIRiC97728.
RefSeqiNP_359864.1. NC_003103.1.
WP_010976891.1. NC_003103.1.

3D structure databases

ProteinModelPortaliQ92J42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272944.RC0227.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL02765; AAL02765; RC0227.
GeneIDi927961.
KEGGirco:RC0227.
PATRICi17887605. VBIRicCon45613_0262.

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiQNQGAWF.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiODO1_RICCN
AccessioniPrimary (citable) accession number: Q92J42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: December 1, 2001
Last modified: March 4, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.