Reviewed, UniProtKB/Swiss-Prot Q92J02 (GLRX1_RICCN)

Names and origin

Protein names

Recommended name:
    Glutaredoxin-1

Gene names

Name:	grxC1
Synonyms:	grx
Ordered Locus Names:	RC0267

Organism

Rickettsia conorii [Complete proteome] [HAMAP]

Taxonomic identifier

781 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	102 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins By similarity.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the glutaredoxin family. Contains 1 glutaredoxin domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Cytoplasm
Domain	Redox-active center
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 102	102	Glutaredoxin-1		PRO_0000288735
Regions
	Domain	1 – 96	96	Glutaredoxin
Amino acid modifications
	Disulfide bond	17 ↔ 20		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92J02-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 7B7844F027B2C989	FASTA	102	11,331
	10 20 30 40 50 60 MNKAILHTII VYTLASCPYC IKAKALLDEK NVAYEEIEVS NFTQEEKEKF IKKSGGKKTV 70 80 90 100 PQIFIDNMHV GGCDALFDLE KEGRLDKLLE NQPKTTSPAA GA

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006914 Genomic DNA. Translation: AAL02805.1.
PIR	C97733.
RefSeq	NP_359904.1.
3D structure databases
HSSP	HSSP built from PDB template 1FOV based on UniProtKB P37687.
ModBase	Search...
Genome annotation databases
GeneID	927911.
GenomeReviews	Gene locus RC0267 in contig AE006914_GR.
KEGG	rco:RC0267.
NMPDR	fig|272944.1.peg.267.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q92J02.
OMA	Q92J02. CDELHAL.
Enzyme and pathway databases
BioCyc	RCON272944:RC0267-MON.
Family and domain databases
InterPro	IPR011767. GLR_AS. IPR002109. Glutaredoxin. IPR014025. Glutaredoxin_sub. IPR011900. GRX_bact. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00462. Glutaredoxin. 1 hit. [Graphical view]
PRINTS	PR00160. GLUTAREDOXIN.
TIGRFAMs	TIGR02181. GRX_bact. 1 hit.
PROSITE	PS00195. GLUTAREDOXIN_1. 1 hit. PS51354. GLUTAREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLRX1_RICCN

Accession

Primary (citable) accession number: Q92J02

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	December 1, 2001
Last modified:	June 16, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)