Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q92IX4

- SYT_RICCN

UniProt

Q92IX4 - SYT_RICCN

Protein

Threonine--tRNA ligase

Gene

thrS

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi333 – 3331Zinc; catalyticUniRule annotation
    Metal bindingi384 – 3841Zinc; catalyticUniRule annotation
    Metal bindingi510 – 5101Zinc; catalyticUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW
    3. threonine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. threonyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Threonine--tRNA ligaseUniRule annotation (EC:6.1.1.3UniRule annotation)
    Alternative name(s):
    Threonyl-tRNA synthetaseUniRule annotation
    Short name:
    ThrRSUniRule annotation
    Gene namesi
    Name:thrSUniRule annotation
    Ordered Locus Names:RC0296
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 635635Threonine--tRNA ligasePRO_0000101036Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272944.RC0296.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92IX4.
    SMRiQ92IX4. Positions 241-631.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni242 – 533292CatalyticAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0441.
    HOGENOMiHOG000003880.
    KOiK01868.
    OMAiHFKLQKI.
    OrthoDBiEOG61KBFJ.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    3.40.50.800. 1 hit.
    HAMAPiMF_00184. Thr_tRNA_synth.
    InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR012675. Beta-grasp_dom.
    IPR004095. TGS.
    IPR012676. TGS-like.
    IPR002320. Thr-tRNA-ligase_IIa.
    IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
    IPR012947. tRNA_SAD.
    [Graphical view]
    PfamiPF03129. HGTP_anticodon. 1 hit.
    PF02824. TGS. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    PF07973. tRNA_SAD. 1 hit.
    [Graphical view]
    PRINTSiPR01047. TRNASYNTHTHR.
    SMARTiSM00863. tRNA_SAD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52954. SSF52954. 1 hit.
    SSF55186. SSF55186. 1 hit.
    SSF81271. SSF81271. 1 hit.
    TIGRFAMsiTIGR00418. thrS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92IX4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MINISFPDGS IKQFAKNITA YEVANAISMS LAKAAMVAEI NGELQDLSIV    50
    IDNDCKLRIL TAQDPECLEI IRHDAAHLTA EAVKELFPET QVTIGPAIEN 100
    GYYYDFARDK PFTTDDLAVI EAKMQELSQK NEQVTRELWD RDKAVEFFKS 150
    IGEHYKAEII ASIPAGEPIT LYRQGNFIDL CRGPHAPSTG VVKHFKLMKV 200
    AGAYWRGDSR NEMLQRIYGT AWATKEQLDS YLLMLEEAEK RDHRKLGREL 250
    DLFHFQEEAQ GMVFWHDKGW SIYNTIEQYI RKKIRKNGYT EVKTPVLVDK 300
    SLWEASGHWE KFRDDMFALE TDDKTLALKP MNCPCHVQIF KQGIKSYRDL 350
    PLRMSEFGLC HRNEASGALH GLMRVRSLVQ DDAHIFCAAE QITDETVSFC 400
    KLLTEVYKDF GFTDIKVKFS DRPEIRAGSN EVWDKAENAL KEAVEQAGFN 450
    YTLNPGEGAF YGPKLEFVLT DAIGRQWQCG TLQMDFVLPE RLDASYVAAS 500
    GEKKRPVMLH RAILGSLERF IGILIEEYAG RFPLWLAPVQ VAIATITSDL 550
    NDYALEVQKA LIDNGVRTDF NISPDKINYK IREFSNQKIP MIAVIGKQEQ 600
    ENKQVAIRRL GTTDQEVLSV EQLIAVVKEE NEKYL 635
    Length:635
    Mass (Da):72,353
    Last modified:December 1, 2001 - v1
    Checksum:iBCF988D88C5CC3EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02834.1.
    PIRiH97736.
    RefSeqiNP_359933.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL02834; AAL02834; RC0296.
    GeneIDi927857.
    KEGGirco:RC0296.
    PATRICi17887760. VBIRicCon45613_0337.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02834.1 .
    PIRi H97736.
    RefSeqi NP_359933.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92IX4.
    SMRi Q92IX4. Positions 241-631.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0296.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL02834 ; AAL02834 ; RC0296 .
    GeneIDi 927857.
    KEGGi rco:RC0296.
    PATRICi 17887760. VBIRicCon45613_0337.

    Phylogenomic databases

    eggNOGi COG0441.
    HOGENOMi HOG000003880.
    KOi K01868.
    OMAi HFKLQKI.
    OrthoDBi EOG61KBFJ.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    3.40.50.800. 1 hit.
    HAMAPi MF_00184. Thr_tRNA_synth.
    InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR012675. Beta-grasp_dom.
    IPR004095. TGS.
    IPR012676. TGS-like.
    IPR002320. Thr-tRNA-ligase_IIa.
    IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
    IPR012947. tRNA_SAD.
    [Graphical view ]
    Pfami PF03129. HGTP_anticodon. 1 hit.
    PF02824. TGS. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    PF07973. tRNA_SAD. 1 hit.
    [Graphical view ]
    PRINTSi PR01047. TRNASYNTHTHR.
    SMARTi SM00863. tRNA_SAD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52954. SSF52954. 1 hit.
    SSF55186. SSF55186. 1 hit.
    SSF81271. SSF81271. 1 hit.
    TIGRFAMsi TIGR00418. thrS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiSYT_RICCN
    AccessioniPrimary (citable) accession number: Q92IX4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Rickettsia conorii
      (strain Malish 7): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3