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Q92IX4 (SYT_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Threonine--tRNA ligase

EC=6.1.1.3
Alternative name(s):
Threonyl-tRNA synthetase
Short name=ThrRS
Gene names
Name:thrS
Ordered Locus Names:RC0296
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length635 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). HAMAP-Rule MF_00184

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00184

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00184

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00184.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processthreonyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

threonine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 635635Threonine--tRNA ligase HAMAP-Rule MF_00184
PRO_0000101036

Regions

Region242 – 533292Catalytic HAMAP-Rule MF_00184

Sites

Metal binding3331Zinc; catalytic By similarity
Metal binding3841Zinc; catalytic By similarity
Metal binding5101Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92IX4 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: BCF988D88C5CC3EB

FASTA63572,353
        10         20         30         40         50         60 
MINISFPDGS IKQFAKNITA YEVANAISMS LAKAAMVAEI NGELQDLSIV IDNDCKLRIL 

        70         80         90        100        110        120 
TAQDPECLEI IRHDAAHLTA EAVKELFPET QVTIGPAIEN GYYYDFARDK PFTTDDLAVI 

       130        140        150        160        170        180 
EAKMQELSQK NEQVTRELWD RDKAVEFFKS IGEHYKAEII ASIPAGEPIT LYRQGNFIDL 

       190        200        210        220        230        240 
CRGPHAPSTG VVKHFKLMKV AGAYWRGDSR NEMLQRIYGT AWATKEQLDS YLLMLEEAEK 

       250        260        270        280        290        300 
RDHRKLGREL DLFHFQEEAQ GMVFWHDKGW SIYNTIEQYI RKKIRKNGYT EVKTPVLVDK 

       310        320        330        340        350        360 
SLWEASGHWE KFRDDMFALE TDDKTLALKP MNCPCHVQIF KQGIKSYRDL PLRMSEFGLC 

       370        380        390        400        410        420 
HRNEASGALH GLMRVRSLVQ DDAHIFCAAE QITDETVSFC KLLTEVYKDF GFTDIKVKFS 

       430        440        450        460        470        480 
DRPEIRAGSN EVWDKAENAL KEAVEQAGFN YTLNPGEGAF YGPKLEFVLT DAIGRQWQCG 

       490        500        510        520        530        540 
TLQMDFVLPE RLDASYVAAS GEKKRPVMLH RAILGSLERF IGILIEEYAG RFPLWLAPVQ 

       550        560        570        580        590        600 
VAIATITSDL NDYALEVQKA LIDNGVRTDF NISPDKINYK IREFSNQKIP MIAVIGKQEQ 

       610        620        630 
ENKQVAIRRL GTTDQEVLSV EQLIAVVKEE NEKYL 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL02834.1.
PIRH97736.
RefSeqNP_359933.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92IX4.
SMRQ92IX4. Positions 241-631.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC0296.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL02834; AAL02834; RC0296.
GeneID927857.
KEGGrco:RC0296.
PATRIC17887760. VBIRicCon45613_0337.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0441.
HOGENOMHOG000003880.
KOK01868.
OMAHFKLQKI.
OrthoDBEOG61KBFJ.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPMF_00184. Thr_tRNA_synth.
InterProIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR012675. Beta-grasp_dom.
IPR004095. TGS.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR012947. tRNA_SAD.
[Graphical view]
PfamPF03129. HGTP_anticodon. 1 hit.
PF02824. TGS. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
PRINTSPR01047. TRNASYNTHTHR.
SMARTSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMSSF52954. SSF52954. 1 hit.
SSF55186. SSF55186. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsTIGR00418. thrS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYT_RICCN
AccessionPrimary (citable) accession number: Q92IX4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries