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Q92IX4

- SYT_RICCN

UniProt

Q92IX4 - SYT_RICCN

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Protein
Threonine--tRNA ligase
Gene
thrS, RC0296
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi333 – 3331Zinc; catalytic By similarity
Metal bindingi384 – 3841Zinc; catalytic By similarity
Metal bindingi510 – 5101Zinc; catalytic By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. threonine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. threonyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine--tRNA ligase (EC:6.1.1.3)
Alternative name(s):
Threonyl-tRNA synthetase
Short name:
ThrRS
Gene namesi
Name:thrS
Ordered Locus Names:RC0296
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Threonine--tRNA ligaseUniRule annotation
PRO_0000101036Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272944.RC0296.

Structurei

3D structure databases

ProteinModelPortaliQ92IX4.
SMRiQ92IX4. Positions 241-631.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni242 – 533292CatalyticUniRule annotation
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0441.
HOGENOMiHOG000003880.
KOiK01868.
OMAiHFKLQKI.
OrthoDBiEOG61KBFJ.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPiMF_00184. Thr_tRNA_synth.
InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR012675. Beta-grasp_dom.
IPR004095. TGS.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR012947. tRNA_SAD.
[Graphical view]
PfamiPF03129. HGTP_anticodon. 1 hit.
PF02824. TGS. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
PRINTSiPR01047. TRNASYNTHTHR.
SMARTiSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
SSF55186. SSF55186. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00418. thrS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92IX4-1 [UniParc]FASTAAdd to Basket

« Hide

MINISFPDGS IKQFAKNITA YEVANAISMS LAKAAMVAEI NGELQDLSIV    50
IDNDCKLRIL TAQDPECLEI IRHDAAHLTA EAVKELFPET QVTIGPAIEN 100
GYYYDFARDK PFTTDDLAVI EAKMQELSQK NEQVTRELWD RDKAVEFFKS 150
IGEHYKAEII ASIPAGEPIT LYRQGNFIDL CRGPHAPSTG VVKHFKLMKV 200
AGAYWRGDSR NEMLQRIYGT AWATKEQLDS YLLMLEEAEK RDHRKLGREL 250
DLFHFQEEAQ GMVFWHDKGW SIYNTIEQYI RKKIRKNGYT EVKTPVLVDK 300
SLWEASGHWE KFRDDMFALE TDDKTLALKP MNCPCHVQIF KQGIKSYRDL 350
PLRMSEFGLC HRNEASGALH GLMRVRSLVQ DDAHIFCAAE QITDETVSFC 400
KLLTEVYKDF GFTDIKVKFS DRPEIRAGSN EVWDKAENAL KEAVEQAGFN 450
YTLNPGEGAF YGPKLEFVLT DAIGRQWQCG TLQMDFVLPE RLDASYVAAS 500
GEKKRPVMLH RAILGSLERF IGILIEEYAG RFPLWLAPVQ VAIATITSDL 550
NDYALEVQKA LIDNGVRTDF NISPDKINYK IREFSNQKIP MIAVIGKQEQ 600
ENKQVAIRRL GTTDQEVLSV EQLIAVVKEE NEKYL 635
Length:635
Mass (Da):72,353
Last modified:December 1, 2001 - v1
Checksum:iBCF988D88C5CC3EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL02834.1.
PIRiH97736.
RefSeqiNP_359933.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL02834; AAL02834; RC0296.
GeneIDi927857.
KEGGirco:RC0296.
PATRICi17887760. VBIRicCon45613_0337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL02834.1 .
PIRi H97736.
RefSeqi NP_359933.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92IX4.
SMRi Q92IX4. Positions 241-631.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272944.RC0296.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL02834 ; AAL02834 ; RC0296 .
GeneIDi 927857.
KEGGi rco:RC0296.
PATRICi 17887760. VBIRicCon45613_0337.

Phylogenomic databases

eggNOGi COG0441.
HOGENOMi HOG000003880.
KOi K01868.
OMAi HFKLQKI.
OrthoDBi EOG61KBFJ.

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPi MF_00184. Thr_tRNA_synth.
InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR012675. Beta-grasp_dom.
IPR004095. TGS.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR012947. tRNA_SAD.
[Graphical view ]
Pfami PF03129. HGTP_anticodon. 1 hit.
PF02824. TGS. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view ]
PRINTSi PR01047. TRNASYNTHTHR.
SMARTi SM00863. tRNA_SAD. 1 hit.
[Graphical view ]
SUPFAMi SSF52954. SSF52954. 1 hit.
SSF55186. SSF55186. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00418. thrS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiSYT_RICCN
AccessioniPrimary (citable) accession number: Q92IX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Rickettsia conorii
    (strain Malish 7): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi