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Protein

DNA topoisomerase 4 subunit B

Gene

parE

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation, Ca2+UniRule annotationNote: Binds two Mg2+ per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn2+ or Ca2+.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei20ATPUniRule annotation1
Binding sitei60ATPUniRule annotation1
Binding sitei87ATPUniRule annotation1
Binding sitei359ATPUniRule annotation1
Metal bindingi445Magnesium 1; catalyticUniRule annotation1
Metal bindingi518Magnesium 1; catalyticUniRule annotation1
Metal bindingi518Magnesium 2UniRule annotation1
Metal bindingi520Magnesium 2UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi129 – 135ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Isomerase, Topoisomerase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRCON272944:G1FZG-514-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomerase 4 subunit BUniRule annotation (EC:5.99.1.3UniRule annotation)
Alternative name(s):
Topoisomerase IV subunit BUniRule annotation
Gene namesi
Name:parEUniRule annotation
Ordered Locus Names:RC0309
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000816 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002731171 – 662DNA topoisomerase 4 subunit BAdd BLAST662

Proteomic databases

PRIDEiQ92IW1

Interactioni

Subunit structurei

Heterotetramer composed of ParC and ParE.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei470Interaction with DNAUniRule annotation1
Sitei473Interaction with DNAUniRule annotation1
Sitei525Interaction with DNAUniRule annotation1
Sitei641Interaction with DNAUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliQ92IW1
SMRiQ92IW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini439 – 553ToprimUniRule annotationAdd BLAST115

Sequence similaritiesi

Belongs to the type II topoisomerase family. ParE type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000075154
KOiK02622
OMAiLADCAGQ
OrthoDBiPOG091H03L6

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.230.10, 1 hit
3.30.565.10, 1 hit
3.40.50.670, 1 hit
HAMAPiMF_00938 ParE_type1, 1 hit
InterProiView protein in InterPro
IPR002288 DNA_gyrase_B_C
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR001241 Topo_IIA
IPR013760 Topo_IIA-like_dom_sf
IPR013759 Topo_IIA_B_C
IPR013506 Topo_IIA_bsu_dom2
IPR018522 TopoIIA_CS
IPR005737 TopoIV_B_Gneg
IPR006171 TOPRIM_domain
PANTHERiPTHR10169 PTHR10169, 1 hit
PfamiView protein in Pfam
PF00204 DNA_gyraseB, 1 hit
PF00986 DNA_gyraseB_C, 1 hit
PF02518 HATPase_c, 1 hit
PF01751 Toprim, 1 hit
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SM00433 TOP2c, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
SSF56719 SSF56719, 1 hit
TIGRFAMsiTIGR01055 parE_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00177 TOPOISOMERASE_II, 1 hit
PS50880 TOPRIM, 1 hit

Sequencei

Sequence statusi: Complete.

Q92IW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLFSFNKE KKNKLVDNNY SAKDIEVLEG LEPVRKRPGM YIGGTDSNAM
60 70 80 90 100
HHLVSEVLDN AMDEAVAGFA SIITITMHHD HSITIFDNGR GIPIDNHPKF
110 120 130 140 150
PDKSALEVIL TTLHSGGKFS NNVYHTAGGL HGVGISVVNA LSKHLEIKVY
160 170 180 190 200
KQGKLYSQSY SKGEKLTDLI CEEASKRLRG TSINFTPDPE IFSEKLHFNP
210 220 230 240 250
KKIYELARSK AYLYRGVTIE WACEVEVQSD IPKKALISFP NGLKDYLSSK
260 270 280 290 300
ITLDNLVIPG IFAGNIESKS DRIKLEWAIC WQNNDSSAFV QSYCNTVPTP
310 320 330 340 350
QGGTHEQGLK SAILRGLKAY GEMIGNKKAA NLTIEDILET ASVVLSIFIA
360 370 380 390 400
EPSFQGQTKE KLVSNGVSKP VENIIKDHFD HFLSSDKALA TNLLEHVISI
410 420 430 440 450
AEFRISKKNE KNISRKNATQ KLRLPGKLAD CTRTSPEGTE LFIVEGDSAG
460 470 480 490 500
GSAKQARNRE TQAVLPLWGK VLNVASSTLE KIVNNQAIQD LEIALACGSL
510 520 530 540 550
KNYKKENLRY EKIIIMTDAD VDGAHIASLL MTFFFLRMPK LVEEGHLYLA
560 570 580 590 600
KPPLYRLTQS NKTYYAGDEE EKAKLMDKLL KASKAKIEVG RFKGLGEMMP
610 620 630 640 650
AQLKETTMHP EKRSLLKVTL ADFQNVDKIV DDLMGKKPEK RFQFIYEQAL
660
VKMDKIISEL DI
Length:662
Mass (Da):73,827
Last modified:December 1, 2001 - v1
Checksum:iD84CB42C32308088
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA Translation: AAL02847.1
PIRiE97738
RefSeqiWP_010976968.1, NC_003103.1

Genome annotation databases

EnsemblBacteriaiAAL02847; AAL02847; RC0309
GeneIDi928839
KEGGirco:RC0309
PATRICifig|272944.4.peg.354

Similar proteinsi

Entry informationi

Entry nameiPARE_RICCN
AccessioniPrimary (citable) accession number: Q92IW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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