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Q92IW1

- PARE_RICCN

UniProt

Q92IW1 - PARE_RICCN

Protein

DNA topoisomerase 4 subunit B

Gene

parE

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.UniRule annotation

    Catalytic activityi

    ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

    Cofactori

    Magnesium. Binds two Mg2+ per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn2+ and Ca2+.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei20 – 201ATPUniRule annotation
    Binding sitei60 – 601ATPUniRule annotation
    Binding sitei87 – 871ATPUniRule annotation
    Binding sitei359 – 3591ATPUniRule annotation
    Metal bindingi445 – 4451Magnesium 1; catalyticUniRule annotation
    Sitei470 – 4701Interaction with DNAUniRule annotation
    Sitei473 – 4731Interaction with DNAUniRule annotation
    Metal bindingi518 – 5181Magnesium 1; catalyticUniRule annotation
    Metal bindingi518 – 5181Magnesium 2UniRule annotation
    Metal bindingi520 – 5201Magnesium 2UniRule annotation
    Sitei525 – 5251Interaction with DNAUniRule annotation
    Sitei641 – 6411Interaction with DNAUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi129 – 1357ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: UniProtKB-HAMAP
    3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP
    4. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. chromosome segregation Source: UniProtKB-HAMAP
    2. DNA topological change Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase, Topoisomerase

    Keywords - Ligandi

    ATP-binding, DNA-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA topoisomerase 4 subunit BUniRule annotation (EC:5.99.1.3UniRule annotation)
    Alternative name(s):
    Topoisomerase IV subunit BUniRule annotation
    Gene namesi
    Name:parEUniRule annotation
    Ordered Locus Names:RC0309
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. chromosome Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 662662DNA topoisomerase 4 subunit BPRO_0000273117Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotetramer composed of ParC and ParE.UniRule annotation

    Protein-protein interaction databases

    STRINGi272944.RC0309.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92IW1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini439 – 553115ToprimUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the type II topoisomerase family. ParE type 1 subfamily.UniRule annotation
    Contains 1 Toprim domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0187.
    HOGENOMiHOG000075154.
    KOiK02622.
    OMAiICEEASK.
    OrthoDBiEOG6P334W.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.30.565.10. 1 hit.
    3.40.50.670. 1 hit.
    HAMAPiMF_00938. ParE_type1.
    InterProiIPR002288. DNA_gyrase_B_C.
    IPR003594. HATPase_ATP-bd.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    IPR001241. Topo_IIA.
    IPR013506. Topo_IIA_bsu_dom2.
    IPR013759. Topo_IIA_cen_dom.
    IPR013760. Topo_IIA_like_dom.
    IPR018522. TopoIIA_CS.
    IPR005737. TopoIV_B_Gneg.
    IPR006171. Toprim_domain.
    [Graphical view]
    PfamiPF00204. DNA_gyraseB. 1 hit.
    PF00986. DNA_gyraseB_C. 1 hit.
    PF02518. HATPase_c. 1 hit.
    PF01751. Toprim. 1 hit.
    [Graphical view]
    PRINTSiPR00418. TPI2FAMILY.
    SMARTiSM00387. HATPase_c. 1 hit.
    SM00433. TOP2c. 1 hit.
    [Graphical view]
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55874. SSF55874. 1 hit.
    SSF56719. SSF56719. 1 hit.
    TIGRFAMsiTIGR01055. parE_Gneg. 1 hit.
    PROSITEiPS00177. TOPOISOMERASE_II. 1 hit.
    PS50880. TOPRIM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92IW1-1 [UniParc]FASTAAdd to Basket

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    MSDLFSFNKE KKNKLVDNNY SAKDIEVLEG LEPVRKRPGM YIGGTDSNAM    50
    HHLVSEVLDN AMDEAVAGFA SIITITMHHD HSITIFDNGR GIPIDNHPKF 100
    PDKSALEVIL TTLHSGGKFS NNVYHTAGGL HGVGISVVNA LSKHLEIKVY 150
    KQGKLYSQSY SKGEKLTDLI CEEASKRLRG TSINFTPDPE IFSEKLHFNP 200
    KKIYELARSK AYLYRGVTIE WACEVEVQSD IPKKALISFP NGLKDYLSSK 250
    ITLDNLVIPG IFAGNIESKS DRIKLEWAIC WQNNDSSAFV QSYCNTVPTP 300
    QGGTHEQGLK SAILRGLKAY GEMIGNKKAA NLTIEDILET ASVVLSIFIA 350
    EPSFQGQTKE KLVSNGVSKP VENIIKDHFD HFLSSDKALA TNLLEHVISI 400
    AEFRISKKNE KNISRKNATQ KLRLPGKLAD CTRTSPEGTE LFIVEGDSAG 450
    GSAKQARNRE TQAVLPLWGK VLNVASSTLE KIVNNQAIQD LEIALACGSL 500
    KNYKKENLRY EKIIIMTDAD VDGAHIASLL MTFFFLRMPK LVEEGHLYLA 550
    KPPLYRLTQS NKTYYAGDEE EKAKLMDKLL KASKAKIEVG RFKGLGEMMP 600
    AQLKETTMHP EKRSLLKVTL ADFQNVDKIV DDLMGKKPEK RFQFIYEQAL 650
    VKMDKIISEL DI 662
    Length:662
    Mass (Da):73,827
    Last modified:December 1, 2001 - v1
    Checksum:iD84CB42C32308088
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02847.1.
    PIRiE97738.
    RefSeqiNP_359946.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL02847; AAL02847; RC0309.
    GeneIDi928839.
    KEGGirco:RC0309.
    PATRICi17887794. VBIRicCon45613_0354.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02847.1 .
    PIRi E97738.
    RefSeqi NP_359946.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92IW1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0309.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL02847 ; AAL02847 ; RC0309 .
    GeneIDi 928839.
    KEGGi rco:RC0309.
    PATRICi 17887794. VBIRicCon45613_0354.

    Phylogenomic databases

    eggNOGi COG0187.
    HOGENOMi HOG000075154.
    KOi K02622.
    OMAi ICEEASK.
    OrthoDBi EOG6P334W.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.30.565.10. 1 hit.
    3.40.50.670. 1 hit.
    HAMAPi MF_00938. ParE_type1.
    InterProi IPR002288. DNA_gyrase_B_C.
    IPR003594. HATPase_ATP-bd.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    IPR001241. Topo_IIA.
    IPR013506. Topo_IIA_bsu_dom2.
    IPR013759. Topo_IIA_cen_dom.
    IPR013760. Topo_IIA_like_dom.
    IPR018522. TopoIIA_CS.
    IPR005737. TopoIV_B_Gneg.
    IPR006171. Toprim_domain.
    [Graphical view ]
    Pfami PF00204. DNA_gyraseB. 1 hit.
    PF00986. DNA_gyraseB_C. 1 hit.
    PF02518. HATPase_c. 1 hit.
    PF01751. Toprim. 1 hit.
    [Graphical view ]
    PRINTSi PR00418. TPI2FAMILY.
    SMARTi SM00387. HATPase_c. 1 hit.
    SM00433. TOP2c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55874. SSF55874. 1 hit.
    SSF56719. SSF56719. 1 hit.
    TIGRFAMsi TIGR01055. parE_Gneg. 1 hit.
    PROSITEi PS00177. TOPOISOMERASE_II. 1 hit.
    PS50880. TOPRIM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiPARE_RICCN
    AccessioniPrimary (citable) accession number: Q92IW1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia conorii
      (strain Malish 7): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3