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Q92IV0

- RPPH_RICCN

UniProt

Q92IV0 - RPPH_RICCN

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Protein
RNA pyrophosphohydrolase
Gene
rppH, invA, nudH, RC0320
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage By similarity.UniRule annotation

Cofactori

Divalent ions By similarity.UniRule annotation

GO - Molecular functioni

  1. hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pyrophosphohydrolase (EC:3.6.1.-)
Alternative name(s):
(Di)nucleoside polyphosphate hydrolase
Gene namesi
Name:rppH
Synonyms:invA, nudH
Ordered Locus Names:RC0320
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161RNA pyrophosphohydrolaseUniRule annotation
PRO_0000057024Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272944.RC0320.

Structurei

3D structure databases

ProteinModelPortaliQ92IV0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 154143Nudix hydrolase
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 6722Nudix boxUniRule annotation
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0494.
HOGENOMiHOG000066722.
KOiK08311.
OMAiGIVICNK.
OrthoDBiEOG6Q2SKR.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_00298. Nudix_RppH.
InterProiIPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92IV0-1 [UniParc]FASTAAdd to Basket

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MSNSSKKHLD LPYRPGVGMM ILNANNHIFV GKRIDTKISA WQMPQGGIVP    50
GETPSIAAMR EMLEEIGSDK GYIIAESKFW YSYDVPSFLI PKLWNGNFRG 100
QKQRWFLIRF TGNNEDININ TSNPEFDQWR WASLDELLSI IIPFKRKLYQ 150
AVVKEFESLI Q 161
Length:161
Mass (Da):18,657
Last modified:December 1, 2001 - v1
Checksum:i4B27422BC247CC79
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL02858.1.
PIRiH97739.
RefSeqiNP_359957.1. NC_003103.1.
WP_010976978.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL02858; AAL02858; RC0320.
GeneIDi927499.
KEGGirco:RC0320.
PATRICi17887822. VBIRicCon45613_0367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL02858.1 .
PIRi H97739.
RefSeqi NP_359957.1. NC_003103.1.
WP_010976978.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92IV0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC0320.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL02858 ; AAL02858 ; RC0320 .
GeneIDi 927499.
KEGGi rco:RC0320.
PATRICi 17887822. VBIRicCon45613_0367.

Phylogenomic databases

eggNOGi COG0494.
HOGENOMi HOG000066722.
KOi K08311.
OMAi GIVICNK.
OrthoDBi EOG6Q2SKR.

Family and domain databases

Gene3Di 3.90.79.10. 1 hit.
HAMAPi MF_00298. Nudix_RppH.
InterProi IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
[Graphical view ]
Pfami PF00293. NUDIX. 1 hit.
[Graphical view ]
SUPFAMi SSF55811. SSF55811. 1 hit.
PROSITEi PS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiRPPH_RICCN
AccessioniPrimary (citable) accession number: Q92IV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi