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Protein

RNA pyrophosphohydrolase

Gene

rppH

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pyrophosphohydrolaseUniRule annotation (EC:3.6.1.-UniRule annotation)
Alternative name(s):
(Di)nucleoside polyphosphate hydrolaseUniRule annotation
Gene namesi
Name:rppHUniRule annotation
Synonyms:invA, nudHUniRule annotation
Ordered Locus Names:RC0320
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000570241 – 161RNA pyrophosphohydrolaseAdd BLAST161

Structurei

3D structure databases

ProteinModelPortaliQ92IV0.
SMRiQ92IV0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 154Nudix hydrolaseUniRule annotationAdd BLAST143

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 67Nudix boxAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family. RppH subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000066722.
KOiK08311.
OMAiRPCVGIM.
OrthoDBiPOG091H0392.

Family and domain databases

CDDicd03671. Ap4A_hydrolase_plant_like. 1 hit.
HAMAPiMF_00298. Nudix_RppH. 1 hit.
InterProiView protein in InterPro
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
PfamiView protein in Pfam
PF00293. NUDIX. 1 hit.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiView protein in PROSITE
PS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92IV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNSSKKHLD LPYRPGVGMM ILNANNHIFV GKRIDTKISA WQMPQGGIVP
60 70 80 90 100
GETPSIAAMR EMLEEIGSDK GYIIAESKFW YSYDVPSFLI PKLWNGNFRG
110 120 130 140 150
QKQRWFLIRF TGNNEDININ TSNPEFDQWR WASLDELLSI IIPFKRKLYQ
160
AVVKEFESLI Q
Length:161
Mass (Da):18,657
Last modified:December 1, 2001 - v1
Checksum:i4B27422BC247CC79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL02858.1.
PIRiH97739.
RefSeqiWP_010976978.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL02858; AAL02858; RC0320.
GeneIDi927499.
KEGGirco:RC0320.
PATRICifig|272944.4.peg.367.

Similar proteinsi

Entry informationi

Entry nameiRPPH_RICCN
AccessioniPrimary (citable) accession number: Q92IV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 1, 2001
Last modified: August 30, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families