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Q92IV0

- RPPH_RICCN

UniProt

Q92IV0 - RPPH_RICCN

Protein

RNA pyrophosphohydrolase

Gene

rppH

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotation

    Cofactori

    Divalent ions.UniRule annotation

    GO - Molecular functioni

    1. hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA pyrophosphohydrolaseUniRule annotation (EC:3.6.1.-UniRule annotation)
    Alternative name(s):
    (Di)nucleoside polyphosphate hydrolaseUniRule annotation
    Gene namesi
    Name:rppHUniRule annotation
    Synonyms:invA, nudHUniRule annotation
    Ordered Locus Names:RC0320
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 161161RNA pyrophosphohydrolasePRO_0000057024Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272944.RC0320.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92IV0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 154143Nudix hydrolaseUniRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi46 – 6722Nudix boxAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Nudix hydrolase family. RppH subfamily.UniRule annotation
    Contains 1 nudix hydrolase domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0494.
    HOGENOMiHOG000066722.
    KOiK08311.
    OMAiGIVICNK.
    OrthoDBiEOG6Q2SKR.

    Family and domain databases

    Gene3Di3.90.79.10. 1 hit.
    HAMAPiMF_00298. Nudix_RppH.
    InterProiIPR020084. NUDIX_hydrolase_CS.
    IPR000086. NUDIX_hydrolase_dom.
    IPR015797. NUDIX_hydrolase_dom-like.
    IPR022927. RppH.
    [Graphical view]
    PfamiPF00293. NUDIX. 1 hit.
    [Graphical view]
    SUPFAMiSSF55811. SSF55811. 1 hit.
    PROSITEiPS51462. NUDIX. 1 hit.
    PS00893. NUDIX_BOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92IV0-1 [UniParc]FASTAAdd to Basket

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    MSNSSKKHLD LPYRPGVGMM ILNANNHIFV GKRIDTKISA WQMPQGGIVP    50
    GETPSIAAMR EMLEEIGSDK GYIIAESKFW YSYDVPSFLI PKLWNGNFRG 100
    QKQRWFLIRF TGNNEDININ TSNPEFDQWR WASLDELLSI IIPFKRKLYQ 150
    AVVKEFESLI Q 161
    Length:161
    Mass (Da):18,657
    Last modified:December 1, 2001 - v1
    Checksum:i4B27422BC247CC79
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02858.1.
    PIRiH97739.
    RefSeqiNP_359957.1. NC_003103.1.
    WP_010976978.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL02858; AAL02858; RC0320.
    GeneIDi927499.
    KEGGirco:RC0320.
    PATRICi17887822. VBIRicCon45613_0367.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02858.1 .
    PIRi H97739.
    RefSeqi NP_359957.1. NC_003103.1.
    WP_010976978.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92IV0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0320.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL02858 ; AAL02858 ; RC0320 .
    GeneIDi 927499.
    KEGGi rco:RC0320.
    PATRICi 17887822. VBIRicCon45613_0367.

    Phylogenomic databases

    eggNOGi COG0494.
    HOGENOMi HOG000066722.
    KOi K08311.
    OMAi GIVICNK.
    OrthoDBi EOG6Q2SKR.

    Family and domain databases

    Gene3Di 3.90.79.10. 1 hit.
    HAMAPi MF_00298. Nudix_RppH.
    InterProi IPR020084. NUDIX_hydrolase_CS.
    IPR000086. NUDIX_hydrolase_dom.
    IPR015797. NUDIX_hydrolase_dom-like.
    IPR022927. RppH.
    [Graphical view ]
    Pfami PF00293. NUDIX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55811. SSF55811. 1 hit.
    PROSITEi PS51462. NUDIX. 1 hit.
    PS00893. NUDIX_BOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiRPPH_RICCN
    AccessioniPrimary (citable) accession number: Q92IV0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia conorii
      (strain Malish 7): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3