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Protein

RNA pyrophosphohydrolase

Gene

rppH

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pyrophosphohydrolaseUniRule annotation (EC:3.6.1.-UniRule annotation)
Alternative name(s):
(Di)nucleoside polyphosphate hydrolaseUniRule annotation
Gene namesi
Name:rppHUniRule annotation
Synonyms:invA, nudHUniRule annotation
Ordered Locus Names:RC0320
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161RNA pyrophosphohydrolasePRO_0000057024Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272944.RC0320.

Structurei

3D structure databases

ProteinModelPortaliQ92IV0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 154143Nudix hydrolaseUniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 6722Nudix boxAdd
BLAST

Sequence similaritiesi

Belongs to the Nudix hydrolase family. RppH subfamily.UniRule annotation
Contains 1 nudix hydrolase domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0494.
HOGENOMiHOG000066722.
KOiK08311.
OMAiRPCVGIM.
OrthoDBiEOG6Q2SKR.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_00298. Nudix_RppH.
InterProiIPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92IV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNSSKKHLD LPYRPGVGMM ILNANNHIFV GKRIDTKISA WQMPQGGIVP
60 70 80 90 100
GETPSIAAMR EMLEEIGSDK GYIIAESKFW YSYDVPSFLI PKLWNGNFRG
110 120 130 140 150
QKQRWFLIRF TGNNEDININ TSNPEFDQWR WASLDELLSI IIPFKRKLYQ
160
AVVKEFESLI Q
Length:161
Mass (Da):18,657
Last modified:December 1, 2001 - v1
Checksum:i4B27422BC247CC79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL02858.1.
PIRiH97739.
RefSeqiNP_359957.1. NC_003103.1.
WP_010976978.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL02858; AAL02858; RC0320.
GeneIDi927499.
KEGGirco:RC0320.
PATRICi17887822. VBIRicCon45613_0367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL02858.1.
PIRiH97739.
RefSeqiNP_359957.1. NC_003103.1.
WP_010976978.1. NC_003103.1.

3D structure databases

ProteinModelPortaliQ92IV0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272944.RC0320.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL02858; AAL02858; RC0320.
GeneIDi927499.
KEGGirco:RC0320.
PATRICi17887822. VBIRicCon45613_0367.

Phylogenomic databases

eggNOGiCOG0494.
HOGENOMiHOG000066722.
KOiK08311.
OMAiRPCVGIM.
OrthoDBiEOG6Q2SKR.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_00298. Nudix_RppH.
InterProiIPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiRPPH_RICCN
AccessioniPrimary (citable) accession number: Q92IV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 1, 2001
Last modified: May 27, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.