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Q92IV0 (RPPH_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA pyrophosphohydrolase

EC=3.6.1.-
Alternative name(s):
(Di)nucleoside polyphosphate hydrolase
Gene names
Name:rppH
Synonyms:invA, nudH
Ordered Locus Names:RC0320
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length161 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage By similarity. HAMAP-Rule MF_00298

Cofactor

Divalent ions By similarity. HAMAP-Rule MF_00298

Sequence similarities

Belongs to the Nudix hydrolase family. RppH subfamily.

Contains 1 nudix hydrolase domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 161161RNA pyrophosphohydrolase HAMAP-Rule MF_00298
PRO_0000057024

Regions

Domain12 – 154143Nudix hydrolase
Motif46 – 6722Nudix box HAMAP-Rule MF_00298

Sequences

Sequence LengthMass (Da)Tools
Q92IV0 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 4B27422BC247CC79

FASTA16118,657
        10         20         30         40         50         60 
MSNSSKKHLD LPYRPGVGMM ILNANNHIFV GKRIDTKISA WQMPQGGIVP GETPSIAAMR 

        70         80         90        100        110        120 
EMLEEIGSDK GYIIAESKFW YSYDVPSFLI PKLWNGNFRG QKQRWFLIRF TGNNEDININ 

       130        140        150        160 
TSNPEFDQWR WASLDELLSI IIPFKRKLYQ AVVKEFESLI Q 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL02858.1.
PIRH97739.
RefSeqNP_359957.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92IV0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC0320.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL02858; AAL02858; RC0320.
GeneID927499.
KEGGrco:RC0320.
PATRIC17887822. VBIRicCon45613_0367.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0494.
HOGENOMHOG000066722.
KOK08311.
OMANSEYDGS.
OrthoDBEOG6Q2SKR.
ProtClustDBPRK00714.

Family and domain databases

Gene3D3.90.79.10. 1 hit.
HAMAPMF_00298. Nudix_RppH.
InterProIPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
[Graphical view]
PfamPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMSSF55811. SSF55811. 1 hit.
PROSITEPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRPPH_RICCN
AccessionPrimary (citable) accession number: Q92IV0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names