Q92IV0 (RPPH_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA pyrophosphohydrolase
EC=3.6.1.-

Alternative name(s):
(Di)nucleoside polyphosphate hydrolase

Gene names

Name:	rppH
Synonyms:	invA, nudH
Ordered Locus Names:	RC0320

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia conorii

Protein attributes

Sequence length	161 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage By similarity. HAMAP-Rule MF_00298
Cofactor	Divalent ions By similarity.
Sequence similarities	Belongs to the Nudix hydrolase family. RppH subfamily. Contains 1 nudix hydrolase domain.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 161	161	RNA pyrophosphohydrolase HAMAP-Rule MF_00298		PRO_0000057024
Regions
	Domain	12 – 154	143	Nudix hydrolase
	Motif	46 – 67	22	Nudix box HAMAP-Rule MF_00298

Sequences

	Sequence		Length	Mass (Da)
	Q92IV0 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 4B27422BC247CC79	FASTA	161	18,657
	10 20 30 40 50 60 MSNSSKKHLD LPYRPGVGMM ILNANNHIFV GKRIDTKISA WQMPQGGIVP GETPSIAAMR 70 80 90 100 110 120 EMLEEIGSDK GYIIAESKFW YSYDVPSFLI PKLWNGNFRG QKQRWFLIRF TGNNEDININ 130 140 150 160 TSNPEFDQWR WASLDELLSI IIPFKRKLYQ AVVKEFESLI Q

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL02858.1.
PIR	H97739.
RefSeq	NP_359957.1. NC_003103.1.
3D structure databases
ProteinModelPortal	Q92IV0.
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC0320.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL02858; AAL02858; RC0320.
GeneID	927499.
KEGG	rco:RC0320.
PATRIC	17887822. VBIRicCon45613_0367.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0494.
HOGENOM	HOG000066722.
KO	K08311.
OMA	PEHVQIL.
ProtClustDB	PRK00714.
Family and domain databases
Gene3D	3.90.79.10. 1 hit.
HAMAP	MF_00298. Nudix_RppH.
InterPro	IPR020084. NUDIX_hydrolase_CS. IPR000086. NUDIX_hydrolase_dom. IPR015797. NUDIX_hydrolase_dom-like. IPR022927. RppH. [Graphical view]
Pfam	PF00293. NUDIX. 1 hit. [Graphical view]
SUPFAM	SSF55811. NUDIX_hydrolase. 1 hit.
PROSITE	PS51462. NUDIX. 1 hit. PS00893. NUDIX_BOX. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RPPH_RICCN

Accession

Primary (citable) accession number: Q92IV0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program