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Q92IV0

- RPPH_RICCN

UniProt

Q92IV0 - RPPH_RICCN

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Protein

RNA pyrophosphohydrolase

Gene

rppH

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

GO - Molecular functioni

  1. hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pyrophosphohydrolaseUniRule annotation (EC:3.6.1.-UniRule annotation)
Alternative name(s):
(Di)nucleoside polyphosphate hydrolaseUniRule annotation
Gene namesi
Name:rppHUniRule annotation
Synonyms:invA, nudHUniRule annotation
Ordered Locus Names:RC0320
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161RNA pyrophosphohydrolasePRO_0000057024Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272944.RC0320.

Structurei

3D structure databases

ProteinModelPortaliQ92IV0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 154143Nudix hydrolaseUniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 6722Nudix boxAdd
BLAST

Sequence similaritiesi

Belongs to the Nudix hydrolase family. RppH subfamily.UniRule annotation
Contains 1 nudix hydrolase domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0494.
HOGENOMiHOG000066722.
KOiK08311.
OMAiGIVICNK.
OrthoDBiEOG6Q2SKR.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_00298. Nudix_RppH.
InterProiIPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92IV0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNSSKKHLD LPYRPGVGMM ILNANNHIFV GKRIDTKISA WQMPQGGIVP
60 70 80 90 100
GETPSIAAMR EMLEEIGSDK GYIIAESKFW YSYDVPSFLI PKLWNGNFRG
110 120 130 140 150
QKQRWFLIRF TGNNEDININ TSNPEFDQWR WASLDELLSI IIPFKRKLYQ
160
AVVKEFESLI Q
Length:161
Mass (Da):18,657
Last modified:December 1, 2001 - v1
Checksum:i4B27422BC247CC79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL02858.1.
PIRiH97739.
RefSeqiNP_359957.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL02858; AAL02858; RC0320.
GeneIDi927499.
KEGGirco:RC0320.
PATRICi17887822. VBIRicCon45613_0367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL02858.1 .
PIRi H97739.
RefSeqi NP_359957.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92IV0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC0320.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL02858 ; AAL02858 ; RC0320 .
GeneIDi 927499.
KEGGi rco:RC0320.
PATRICi 17887822. VBIRicCon45613_0367.

Phylogenomic databases

eggNOGi COG0494.
HOGENOMi HOG000066722.
KOi K08311.
OMAi GIVICNK.
OrthoDBi EOG6Q2SKR.

Family and domain databases

Gene3Di 3.90.79.10. 1 hit.
HAMAPi MF_00298. Nudix_RppH.
InterProi IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
[Graphical view ]
Pfami PF00293. NUDIX. 1 hit.
[Graphical view ]
SUPFAMi SSF55811. SSF55811. 1 hit.
PROSITEi PS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiRPPH_RICCN
AccessioniPrimary (citable) accession number: Q92IV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3