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Q92IS3

- ODPA_RICCN

UniProt

Q92IS3 - ODPA_RICCN

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Protein
Pyruvate dehydrogenase E1 component subunit alpha
Gene
pdhA, RC0347
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Gene namesi
Name:pdhA
Ordered Locus Names:RC0347
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular membrane-bounded organelle Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Pyruvate dehydrogenase E1 component subunit alpha
PRO_0000162203Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

STRINGi272944.RC0347.

Structurei

3D structure databases

ProteinModelPortaliQ92IS3.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1071.
HOGENOMiHOG000281336.
KOiK00161.
OMAiEYAMGTS.
OrthoDBiEOG6JMMWC.

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
TIGRFAMsiTIGR03182. PDH_E1_alph_y. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92IS3-1 [UniParc]FASTAAdd to Basket

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MDIKLGKYKP TKEEYIKSFK DMLLLRRFEE KCGQLYGMGE IGGFCHLYIG    50
QEAVISAIDM VKQKGDSTIT SYRDHAHIIL AGTEPKYVLA ELMGRATGCS 100
KGKGGSMHLF NVPNKFYGGH GIVGAQVPIG TGLAFVEKYN DTHNICFTFL 150
GDGAVNQGQV YEAFNMAALW GLPVVYIIEN NEYSMGTSVA RSTFMRDLYK 200
KGASFGIKGF QLDGMDFEEM YDGSKQAAEY VRENSFPLIL EVKTYRYRGH 250
SMSDPAKYRS KEEVEQYKER DPLVIIRKTI LDNKYVTEAD LKAIEQSVKE 300
IVKEAVEFSE NSPLPDEGEL YTQVYC 326
Length:326
Mass (Da):36,736
Last modified:December 1, 2001 - v1
Checksum:iBC588D2C9EFFABD9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL02885.1.
PIRiC97743.
RefSeqiNP_359984.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL02885; AAL02885; RC0347.
GeneIDi927514.
KEGGirco:RC0347.
PATRICi17887878. VBIRicCon45613_0395.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL02885.1 .
PIRi C97743.
RefSeqi NP_359984.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92IS3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC0347.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL02885 ; AAL02885 ; RC0347 .
GeneIDi 927514.
KEGGi rco:RC0347.
PATRICi 17887878. VBIRicCon45613_0395.

Phylogenomic databases

eggNOGi COG1071.
HOGENOMi HOG000281336.
KOi K00161.
OMAi EYAMGTS.
OrthoDBi EOG6JMMWC.

Family and domain databases

Gene3Di 3.40.50.970. 1 hit.
InterProi IPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
[Graphical view ]
Pfami PF00676. E1_dh. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 1 hit.
TIGRFAMsi TIGR03182. PDH_E1_alph_y. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiODPA_RICCN
AccessioniPrimary (citable) accession number: Q92IS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names

External Data

Dasty 3

Similar proteinsi