Reviewed,
UniProtKB/Swiss-Prot Q92IS3 (ODPA_RICCN)
Last modified
November 4, 2008.
Version 38.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Pyruvate dehydrogenase E1 component subunit alpha EC=1.2.4.1 | ||||
| Gene names |
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| Organism | Rickettsia conorii [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 781 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group |
Protein attributes
| Sequence length | 326 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. |
| Catalytic activity | Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2). |
| Cofactor | Thiamine pyrophosphate By similarity. |
| Subunit structure | Heterodimer of an alpha and a beta chain. |
Ontologies
Keywords | |
|---|---|
| Biological process | Glycolysis |
| Ligand | Pyruvate Thiamine pyrophosphate |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | glycolysis Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | pyruvate dehydrogenase (acetyl-transferring) activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 326 | 326 | Pyruvate dehydrogenase E1 component subunit alpha | PRO_0000162203 | |||
Sequences
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References
| [1] | "Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7. |
Cross-references
Sequence databases | |
|---|---|
| AE008600 Genomic DNA. Translation: AAL02885.1. | |
| PIR | C97743. |
| RefSeq | NP_359984.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1NI4 based on UniProtKB P08559. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 927514. |
| GenomeReviews | Gene locus RC0347 in contig AE006914_GR. |
| KEGG | rco:RC0347. |
| NMPDR | fig|272944.1.peg.347. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q92IS3. |
Enzyme and pathway databases | |
| BioCyc | RCON272944:RC0347-MON. |
Family and domain databases | |
| InterPro | IPR001017. DHase_E1. IPR017597. Pyrv_DH_E1_asu_subgrp-y. [Graphical view] |
| Pfam | PF00676. E1_dh. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ODPA_RICCN | ||||||||
| Accession | Primary (citable) accession number: Q92IS3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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