Reviewed, UniProtKB/Swiss-Prot Q92IS2 (ODPB_RICCN)

Names and origin

Protein names

Recommended name:
    Pyruvate dehydrogenase E1 component subunit beta
    EC=1.2.4.1

Gene names

Name:	pdhB
Ordered Locus Names:	RC0348

Organism

Rickettsia conorii [Complete proteome] [HAMAP]

Taxonomic identifier

781 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.
Catalytic activity	Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).
Cofactor	Thiamine pyrophosphate By similarity.
Subunit structure	Heterodimer of an alpha and a beta chain.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Pyruvate Thiamine pyrophosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	pyruvate dehydrogenase (acetyl-transferring) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Pyruvate dehydrogenase E1 component subunit beta		PRO_0000162226
Sites
	Binding site	59	1	Thiamine pyrophosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92IS2-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 21A97CE0774EA9AE	FASTA	326	35,821
	10 20 30 40 50 60 MQITVREALR DAMQEEMIRD DKVFVIGEEV AEYQGAYKVT QGLLEQFGPK RVIDTPITEY 70 80 90 100 110 120 GFAGLAVGAA FAGLRPIVEF MTFNFAMQAF DHIVNSAAKT HYMSGGQVKC PIVFRGPNGA 130 140 150 160 170 180 ASRVAAQHSQ NYTACYSHIP GLKVVAPYSA EDHKGLMLTA IRDDNPVVFL ENEILYGHSF 190 200 210 220 230 240 DVPKTIEPIP FGQAKILREG SSVTIVTFSI QVKLALDAAN FVQNDNIDCE VIDLRTIKPL 250 260 270 280 290 300 DTETIIESVK KTNRLVVVEE GWFFAGVGAS IASIVMKEAF DYLDAPIEIV SGKDLPLPYA 310 320 VNLETLALPS ESDVIEAVKK VCYYSI

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE008600 Genomic DNA. Translation: AAL02886.1.
PIR	D97743.
RefSeq	NP_359985.1.
3D structure databases
HSSP	HSSP built from PDB template 1IK6 based on UniProtKB Q8ZUR7.
ModBase	Search...
Genome annotation databases
GeneID	928543.
GenomeReviews	Gene locus RC0348 in contig AE006914_GR.
KEGG	rco:RC0348.
NMPDR	fig|272944.1.peg.348.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q92IS2.
Enzyme and pathway databases
BioCyc	RCON272944:RC0348-MON.
Family and domain databases
InterPro	IPR005476. Transketo_C. IPR005475. Transketo_Cen_R. IPR015941. Transketolase_C-like. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ODPB_RICCN

Accession

Primary (citable) accession number: Q92IS2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2003
Last sequence update:	December 1, 2001
Last modified:	November 4, 2008
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)