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Q92IR7

- IDH_RICCN

UniProt

Q92IR7 - IDH_RICCN

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei89 – 891SubstrateBy similarity
    Binding sitei99 – 991SubstrateBy similarity
    Binding sitei121 – 1211SubstrateBy similarity
    Sitei128 – 1281Critical for catalysisBy similarity
    Sitei175 – 1751Critical for catalysisBy similarity
    Metal bindingi208 – 2081Magnesium or manganeseBy similarity
    Binding sitei208 – 2081SubstrateBy similarity
    Metal bindingi232 – 2321Magnesium or manganeseBy similarity
    Metal bindingi236 – 2361Magnesium or manganeseBy similarity

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
    Short name:
    IDH
    Alternative name(s):
    IDP
    NADP(+)-specific ICDH
    Oxalosuccinate decarboxylase
    Gene namesi
    Name:icd
    Ordered Locus Names:RC0353
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 483483Isocitrate dehydrogenase [NADP]PRO_0000083556Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei83 – 831PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi272944.RC0353.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92IR7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0473.
    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiTPIAWEP.
    OrthoDBiEOG65XN31.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR014273. Isocitrate_DH_aproteobac-typ.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02924. ICDH_alpha. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92IR7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEFTPITIA YGDGIGPEIM EAVLYILRKA EARIRLETIE VGEKLYKKHY    50
    TSGISEESWE SIQRTGIILK APITTPQGGG YKSLNVTIRK TLQLFANIRP 100
    AVSLHPFTRT LHPNLNLTII RENEEDLYAG IEYRQTHNMY ESMKLISHTG 150
    CEKIIRYAFE YAVKNNRKKV MCLSKDNIMK FSDGVLHKVF NEIAKEYPQI 200
    NNAHYIIDIG TARLATKPEI FDVIVTSNLY GDIISDVAAE ISGSVGLAGS 250
    ANIGQHYAMF EAVHGSAPDI AGKDIANPSG LLNAAIMMLV HIGQGDIATL 300
    IENAWKKTIE DGVHTADIYN EQSSSKKVGT KEFAEEVTKR LGQLPTKLPK 350
    ADYPLIAEKQ ESNIDYKIDT KEVKKLVGTD IFVNMNVSSA HDIADKINKL 400
    DLGNFELKTI SSKGLKLWPR DTRFETVSDH WCCRFMNKDG TEIKHLDITR 450
    LLEALSTANI DFIKVENLFE FDGVAGYSLA QGE 483
    Length:483
    Mass (Da):53,936
    Last modified:December 1, 2001 - v1
    Checksum:i126975F8A50545A4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02891.1.
    PIRiA97744.
    RefSeqiNP_359990.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL02891; AAL02891; RC0353.
    GeneIDi927516.
    KEGGirco:RC0353.
    PATRICi17887892. VBIRicCon45613_0402.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02891.1 .
    PIRi A97744.
    RefSeqi NP_359990.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92IR7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0353.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL02891 ; AAL02891 ; RC0353 .
    GeneIDi 927516.
    KEGGi rco:RC0353.
    PATRICi 17887892. VBIRicCon45613_0402.

    Phylogenomic databases

    eggNOGi COG0473.
    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi TPIAWEP.
    OrthoDBi EOG65XN31.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR014273. Isocitrate_DH_aproteobac-typ.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02924. ICDH_alpha. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiIDH_RICCN
    AccessioniPrimary (citable) accession number: Q92IR7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia conorii
      (strain Malish 7): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3