Reviewed, UniProtKB/Swiss-Prot Q92IR7 (IDH_RICCN)

Names and origin

Protein names

Recommended name:
    Isocitrate dehydrogenase [NADP]
      Short name=IDH
    EC=1.1.1.42
Alternative name(s):
    Oxalosuccinate decarboxylase
    NADP(+)-specific ICDH
    IDP

Gene names

Name:	icd
Ordered Locus Names:	RC0353

Organism

Rickettsia conorii [Complete proteome] [HAMAP]

Taxonomic identifier

781 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	483 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. Oxalosuccinate + NADP+ = 2-oxoglutarate + CO2 + NADPH.
Cofactor	Binds 1 magnesium or manganese ion per subunit By similarity.
Sequence similarities	Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Ontologies

Keywords
Biological process	Glyoxylate bypass Tricarboxylic acid cycle
Ligand	Magnesium Manganese Metal-binding NADP
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glyoxylate cycle Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 483	483	Isocitrate dehydrogenase [NADP]		PRO_0000083556
Sites
	Metal binding	208	1	Magnesium or manganese By similarity
	Metal binding	232	1	Magnesium or manganese By similarity
	Metal binding	236	1	Magnesium or manganese By similarity
	Binding site	89	1	Substrate By similarity
	Binding site	99	1	Substrate By similarity
	Binding site	121	1	Substrate By similarity
	Binding site	208	1	Substrate By similarity
	Site	128	1	Critical for catalysis By similarity
	Site	175	1	Critical for catalysis By similarity
Amino acid modifications
	Modified residue	83	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92IR7-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 126975F8A50545A4	FASTA	483	53,936
	10 20 30 40 50 60 MAEFTPITIA YGDGIGPEIM EAVLYILRKA EARIRLETIE VGEKLYKKHY TSGISEESWE 70 80 90 100 110 120 SIQRTGIILK APITTPQGGG YKSLNVTIRK TLQLFANIRP AVSLHPFTRT LHPNLNLTII 130 140 150 160 170 180 RENEEDLYAG IEYRQTHNMY ESMKLISHTG CEKIIRYAFE YAVKNNRKKV MCLSKDNIMK 190 200 210 220 230 240 FSDGVLHKVF NEIAKEYPQI NNAHYIIDIG TARLATKPEI FDVIVTSNLY GDIISDVAAE 250 260 270 280 290 300 ISGSVGLAGS ANIGQHYAMF EAVHGSAPDI AGKDIANPSG LLNAAIMMLV HIGQGDIATL 310 320 330 340 350 360 IENAWKKTIE DGVHTADIYN EQSSSKKVGT KEFAEEVTKR LGQLPTKLPK ADYPLIAEKQ 370 380 390 400 410 420 ESNIDYKIDT KEVKKLVGTD IFVNMNVSSA HDIADKINKL DLGNFELKTI SSKGLKLWPR 430 440 450 460 470 480 DTRFETVSDH WCCRFMNKDG TEIKHLDITR LLEALSTANI DFIKVENLFE FDGVAGYSLA QGE

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006914 Genomic DNA. Translation: AAL02891.1.
PIR	A97744.
RefSeq	NP_359990.1.
3D structure databases
HSSP	HSSP built from PDB template 1HQS based on UniProtKB P39126.
ModBase	Search...
Genome annotation databases
GeneID	927516.
GenomeReviews	Gene locus RC0353 in contig AE006914_GR.
KEGG	rco:RC0353.
NMPDR	fig|272944.1.peg.353.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q92IR7.
OMA	Q92IR7. DNIMKMT.
Enzyme and pathway databases
BioCyc	RCON272944:RC0353-MON.
BRENDA	1.1.1.42. 267518.
Family and domain databases
InterPro	IPR019818. IsoCit/isopropylmalate_DH_CS. IPR001804. Isocitrate/isopropylmalate_DH. IPR014273. Isocitrate_DH_bac. [Graphical view]
Gene3D	G3DSA:3.40.718.10. IDH_IMDH. 1 hit.
PANTHER	PTHR11835. IDH_IMDH_dimeric. 1 hit.
Pfam	PF00180. Iso_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR02924. ICDH_alpha. 1 hit.
PROSITE	PS00470. IDH_IMDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IDH_RICCN

Accession

Primary (citable) accession number: Q92IR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	December 1, 2001
Last modified:	June 16, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)