SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q92IR7

- IDH_RICCN

UniProt

Q92IR7 - IDH_RICCN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Isocitrate dehydrogenase [NADP]

Gene
icd, RC0353
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei89 – 891Substrate By similarity
Binding sitei99 – 991Substrate By similarity
Binding sitei121 – 1211Substrate By similarity
Sitei128 – 1281Critical for catalysis By similarity
Sitei175 – 1751Critical for catalysis By similarity
Metal bindingi208 – 2081Magnesium or manganese By similarity
Binding sitei208 – 2081Substrate By similarity
Metal bindingi232 – 2321Magnesium or manganese By similarity
Metal bindingi236 – 2361Magnesium or manganese By similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Ordered Locus Names:RC0353
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Isocitrate dehydrogenase [NADP]PRO_0000083556Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei83 – 831Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi272944.RC0353.

Structurei

3D structure databases

ProteinModelPortaliQ92IR7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0473.
HOGENOMiHOG000021113.
KOiK00031.
OMAiTPIAWEP.
OrthoDBiEOG65XN31.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR014273. Isocitrate_DH_aproteobac-typ.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02924. ICDH_alpha. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92IR7-1 [UniParc]FASTAAdd to Basket

« Hide

MAEFTPITIA YGDGIGPEIM EAVLYILRKA EARIRLETIE VGEKLYKKHY    50
TSGISEESWE SIQRTGIILK APITTPQGGG YKSLNVTIRK TLQLFANIRP 100
AVSLHPFTRT LHPNLNLTII RENEEDLYAG IEYRQTHNMY ESMKLISHTG 150
CEKIIRYAFE YAVKNNRKKV MCLSKDNIMK FSDGVLHKVF NEIAKEYPQI 200
NNAHYIIDIG TARLATKPEI FDVIVTSNLY GDIISDVAAE ISGSVGLAGS 250
ANIGQHYAMF EAVHGSAPDI AGKDIANPSG LLNAAIMMLV HIGQGDIATL 300
IENAWKKTIE DGVHTADIYN EQSSSKKVGT KEFAEEVTKR LGQLPTKLPK 350
ADYPLIAEKQ ESNIDYKIDT KEVKKLVGTD IFVNMNVSSA HDIADKINKL 400
DLGNFELKTI SSKGLKLWPR DTRFETVSDH WCCRFMNKDG TEIKHLDITR 450
LLEALSTANI DFIKVENLFE FDGVAGYSLA QGE 483
Length:483
Mass (Da):53,936
Last modified:December 1, 2001 - v1
Checksum:i126975F8A50545A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL02891.1.
PIRiA97744.
RefSeqiNP_359990.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL02891; AAL02891; RC0353.
GeneIDi927516.
KEGGirco:RC0353.
PATRICi17887892. VBIRicCon45613_0402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL02891.1 .
PIRi A97744.
RefSeqi NP_359990.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92IR7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC0353.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL02891 ; AAL02891 ; RC0353 .
GeneIDi 927516.
KEGGi rco:RC0353.
PATRICi 17887892. VBIRicCon45613_0402.

Phylogenomic databases

eggNOGi COG0473.
HOGENOMi HOG000021113.
KOi K00031.
OMAi TPIAWEP.
OrthoDBi EOG65XN31.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR014273. Isocitrate_DH_aproteobac-typ.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02924. ICDH_alpha. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiIDH_RICCN
AccessioniPrimary (citable) accession number: Q92IR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi