Reviewed, UniProtKB/Swiss-Prot Q92IR2 (UCRI_RICCN)

Names and origin

Protein names

Recommended name:
    Ubiquinol-cytochrome c reductase iron-sulfur subunit
    EC=1.10.2.2
Alternative name(s):
    Rieske iron-sulfur protein
      Short name=RISP

Gene names

Name:	petA
Ordered Locus Names:	RC0358

Organism

Rickettsia conorii [Complete proteome] [HAMAP]

Taxonomic identifier

781 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
Catalytic activity	QH(2) + 2 ferricytochrome c = Q + 2 ferrocytochrome c + 2 H(+).
Cofactor	Binds 1 2Fe-2S cluster per subunit By similarity.
Subunit structure	The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.
Subcellular location	Cell membrane; Single-pass membrane proteinPotential.
Miscellaneous	The Rieske protein is a high potential 2Fe-2S protein.
Sequence similarities	Contains 1 Rieske domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	2Fe-2S Iron Iron-sulfur Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW ubiquinol-cytochrome-c reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 177	177	Ubiquinol-cytochrome c reductase iron-sulfur subunit		PRO_0000286642
Regions
	Transmembrane	18 – 38	21	Potential
	Domain	88 – 175	88	Rieske
Sites
	Metal binding	120	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	122	1	Iron-sulfur (2Fe-2S); via pros nitrogen By similarity
	Metal binding	139	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	142	1	Iron-sulfur (2Fe-2S); via pros nitrogen By similarity
Amino acid modifications
	Disulfide bond	125 ↔ 141		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92IR2-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: C40EAD3C4D1ABD40	FASTA	177	19,211
	10 20 30 40 50 60 MSDTEDNKNK QTTRRDFMVL TASSVAAIGA VCTLWPLVDS LNPSADVLAL SSIEVDLSNI 70 80 90 100 110 120 AVGQTVTVKW QGKPVFITNR TPDKIAEARA VKMSELIDPE ADQARVKAGH DNWLVTIGIC 130 140 150 160 170 THLGCVPLAN QGEYDGWFCP CHGSQYDSSG RVRRGPAPLN LAVPPYTFIS DKKIRIG

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE008601 Genomic DNA. Translation: AAL02896.1.
PIR	F97744.
RefSeq	NP_359995.1.
3D structure databases
HSSP	HSSP built from PDB template 1RIE based on UniProtKB P13272.
ModBase	Search...
Genome annotation databases
GeneID	927519.
GenomeReviews	Gene locus RC0358 in contig AE006914_GR.
KEGG	rco:RC0358.
NMPDR	fig|272944.1.peg.358.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q92IR2.
Enzyme and pathway databases
BioCyc	RCON272944:RC0358-MON.
Family and domain databases
InterPro	IPR014349. Rieske. IPR005805. Rieske_C. IPR006317. Rieske_proteo. IPR005806. Rieske_reg. IPR006311. Tat. [Graphical view]
Gene3D	G3DSA:2.102.10.10. Rieske_reg. 1 hit.
PANTHER	PTHR10134. Rieske. 1 hit.
Pfam	PF00355. Rieske. 1 hit. [Graphical view]
PRINTS	PR00162. RIESKE.
TIGRFAMs	TIGR01416. Rieske_proteo. 1 hit. TIGR01409. TAT_signal_seq. 1 hit.
PROSITE	PS51296. RIESKE. 1 hit. PS51318. TAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UCRI_RICCN

Accession

Primary (citable) accession number: Q92IR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	December 1, 2001
Last modified:	November 25, 2008
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)