Q92IQ2 (RF2_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide chain release factor 2
Short name=RF-2

Gene names

Name:	prfB
Ordered Locus Names:	RC0368

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia conorii

Protein attributes

Sequence length	368 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA By similarity. HAMAP-Rule MF_00094
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00094.
Post-translational modification	Methylated by PrmC. Methylation increases the termination efficiency of RF2 By similarity. HAMAP-Rule MF_00094
Sequence similarities	Belongs to the prokaryotic/mitochondrial release factor family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
PTM	Methylation
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	translation release factor activity, codon specific Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 368	368	Peptide chain release factor 2 HAMAP-Rule MF_00094		PRO_0000166838
Amino acid modifications
	Modified residue	250	1	N5-methylglutamine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92IQ2 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: A63C0FD338F7081F	FASTA	368	41,540
	10 20 30 40 50 60 MRAEIENYVK KIEQSLELLW RSLDVEASTE RLNALEELTA DPSLWNDQAN AQKLLREKSN 70 80 90 100 110 120 LEEKLNAFNK LKSNLKDALE LEEMAEAEND LETLSQIEQD LKNLSIIAAK FETECLFSGE 130 140 150 160 170 180 ADGNNCFLEI NAGAGGTESH DWASIMMRMY LRFAERLGFK TEIINMINGE EAGIKSCTIR 190 200 210 220 230 240 IIGKRAYGWF KTETGVHRLV RISPFNAAGK RMTSFASSWV YPEIDDNIAI TIEDKDLRID 250 260 270 280 290 300 TFRASGAGGQ HVNTTDSAVR ITHIPTGTVT QCQSDRSQHK NKAQAMKMLQ AKLYELEMQK 310 320 330 340 350 360 RTDSVNEQNA AKTDNSWGHQ IRSYVLQPYH MVKDLRTDYE TSDTKGVLDG DLEEFVSAHL AMNVGGKK

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL02906.1.
PIR	H97745.
RefSeq	NP_360005.1. NC_003103.1.
3D structure databases
ProteinModelPortal	Q92IQ2.
SMR	Q92IQ2. Positions 4-364.
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC0368.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL02906; AAL02906; RC0368.
GeneID	928554.
KEGG	rco:RC0368.
PATRIC	17887924. VBIRicCon45613_0418.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1186.
HOGENOM	HOG000074814.
KO	K02836.
OMA	KAWDMLR.
ProtClustDB	PRK00578.
Family and domain databases
Gene3D	3.30.160.20. 1 hit.
HAMAP	MF_00094. Rel_fac_2.
InterPro	IPR014720. dsRNA-bd-like_dom. IPR005139. PCRF. IPR000352. Pep_chain_release_fac_I_II. IPR020853. Peptide_chain_release_fac2_bac. IPR004374. PrfB. [Graphical view]
PANTHER	PTHR11075:SF6. PTHR11075:SF6. 1 hit.
Pfam	PF03462. PCRF. 1 hit. PF00472. RF-1. 1 hit. [Graphical view]
SMART	SM00937. PCRF. 1 hit. [Graphical view]
TIGRFAMs	TIGR00020. prfB. 1 hit.
PROSITE	PS00745. RF_PROK_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RF2_RICCN

Accession

Primary (citable) accession number: Q92IQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program