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Q92IQ2 (RF2_RICCN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptide chain release factor 2

Short name=RF-2
Gene names
Name:prfB
Ordered Locus Names:RC0368
OrganismRickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]
Taxonomic identifier272944 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA By similarity. HAMAP-Rule MF_00094

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00094.

Post-translational modification

Methylated by PrmC. Methylation increases the termination efficiency of RF2 By similarity. HAMAP-Rule MF_00094

Sequence similarities

Belongs to the prokaryotic/mitochondrial release factor family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   PTMMethylation
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontranslation release factor activity, codon specific

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 368368Peptide chain release factor 2 HAMAP-Rule MF_00094
PRO_0000166838

Amino acid modifications

Modified residue2501N5-methylglutamine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92IQ2 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: A63C0FD338F7081F

FASTA36841,540
        10         20         30         40         50         60 
MRAEIENYVK KIEQSLELLW RSLDVEASTE RLNALEELTA DPSLWNDQAN AQKLLREKSN 

        70         80         90        100        110        120 
LEEKLNAFNK LKSNLKDALE LEEMAEAEND LETLSQIEQD LKNLSIIAAK FETECLFSGE 

       130        140        150        160        170        180 
ADGNNCFLEI NAGAGGTESH DWASIMMRMY LRFAERLGFK TEIINMINGE EAGIKSCTIR 

       190        200        210        220        230        240 
IIGKRAYGWF KTETGVHRLV RISPFNAAGK RMTSFASSWV YPEIDDNIAI TIEDKDLRID 

       250        260        270        280        290        300 
TFRASGAGGQ HVNTTDSAVR ITHIPTGTVT QCQSDRSQHK NKAQAMKMLQ AKLYELEMQK 

       310        320        330        340        350        360 
RTDSVNEQNA AKTDNSWGHQ IRSYVLQPYH MVKDLRTDYE TSDTKGVLDG DLEEFVSAHL 


AMNVGGKK 

« Hide

References

[1]"Mechanisms of evolution in Rickettsia conorii and R. prowazekii."
Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.
Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006914 Genomic DNA. Translation: AAL02906.1.
PIRH97745.
RefSeqNP_360005.1. NC_003103.1.

3D structure databases

ProteinModelPortalQ92IQ2.
SMRQ92IQ2. Positions 4-364.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272944.RC0368.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL02906; AAL02906; RC0368.
GeneID928554.
KEGGrco:RC0368.
PATRIC17887924. VBIRicCon45613_0418.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1186.
HOGENOMHOG000074814.
KOK02836.
OMADINESDC.
OrthoDBEOG6TN48J.
ProtClustDBPRK00578.

Family and domain databases

Gene3D3.30.160.20. 1 hit.
HAMAPMF_00094. Rel_fac_2.
InterProIPR014720. dsRNA-bd_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR020853. Peptide_chain_release_fac2_bac.
IPR004374. PrfB.
[Graphical view]
PANTHERPTHR11075:SF6. PTHR11075:SF6. 1 hit.
PfamPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsTIGR00020. prfB. 1 hit.
PROSITEPS00745. RF_PROK_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRF2_RICCN
AccessionPrimary (citable) accession number: Q92IQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia conorii

(strain Malish 7): entries and gene names