Q92IL9 (MUTS_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA mismatch repair protein MutS

Gene names

Name:	mutS
Ordered Locus Names:	RC0401

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia conorii

Protein attributes

Sequence length	890 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity By similarity. HAMAP-Rule MF_00096
Sequence similarities	Belongs to the DNA mismatch repair MutS family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	mismatch repair Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP damaged DNA binding Inferred from electronic annotation. Source: HAMAP mismatched DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 890	890	DNA mismatch repair protein MutS HAMAP-Rule MF_00096		PRO_0000115129
Regions
	Nucleotide binding	645 – 652	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q92IL9 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 5016F26921D16792	FASTA	890	100,377
	10 20 30 40 50 60 MLLNMNLQEL KQKYNYDVAT KMMQQYLDIK FAHLDCLLLF RMGDFYEMFY EDAILASNVL 70 80 90 100 110 120 GIALTKRGKN GEEEIAMCGV PYHALENYLT KLIEANYKVA ICDQLETPEE AKNRGGYKAV 130 140 150 160 170 180 VTRDVTRIIT PGTIIEENLI ASAEPNYLAS LVIPKNKETA SLCYVDLSTS EIVVVNVPET 190 200 210 220 230 240 EILNELARLK PREILLSENL RSSNLADSIF KQLNFRITYQ VDSFFAINKC EKIILDFYKM 250 260 270 280 290 300 KDIKGIGEIS SSQICAIGSV LEYLSLTQKQ NIPHLPIPRI IKFHSYMTID FSTRRNLEIV 310 320 330 340 350 360 TNSQGGSQGS LLSTLNHTVT KQGGRLLYNF LSSPLTNIAK INHRLNITEF FYSNLEIVKK 370 380 390 400 410 420 IRELLKKTSD IERCLTRITM NRSSGRDLLS IKYTLETATI IKGVFFDAYG FNLPDFIEKI 430 440 450 460 470 480 IKPLSGDAEL YNLIDETIRE DAPNNLNDGG IIKHEYHPKV AQLHDLINNG KLYIEKLKDQ 490 500 510 520 530 540 YRKETGIDSL KISHNNVIGL FIDITAKNVN KILDPKFIHR QTTVNHVRYT TAELQKLESE 550 560 570 580 590 600 LVNAKTLVIS LEKELYADIC SQVIEKASYL RMLASSLSGL DVFCNFAYIA DEYDYVKPEF 610 620 630 640 650 660 TDDLSFDIVK GRHPVVEKAL QRESKSFVYN DCHLSELERI WLITGPNMAG KSTFLRQNAI 670 680 690 700 710 720 IAIIAQIGSF VPAKSAKIGV VDKIFSRIGA ADDLIKGQST FMAEMLETSA ILAQSTKNSL 730 740 750 760 770 780 IILDEVGRGT STYDGVSIAW SVLEYIHDKL KCRCLFATHY HELTVMSNFL PALQNYTIAI 790 800 810 820 830 840 EESGKDILFL HNIISGAADR SYGLHVAALA GLPASVINRA EQILLKFEKT STGKGKNILS 850 860 870 880 890 TESNNLSLFY LEPNKTTISS KLDKKFSTID PDKLSPKEAL ELIYELKKLV

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL02939.1.
PIR	A97750.
RefSeq	NP_360038.1. NC_003103.1.
3D structure databases
ProteinModelPortal	Q92IL9.
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC0401.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL02939; AAL02939; RC0401.
GeneID	928580.
KEGG	rco:RC0401.
PATRIC	17888001. VBIRicCon45613_0456.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0249.
HOGENOM	HOG000221406.
KO	K03555.
OMA	HYFELTV.
ProtClustDB	PRK05399.
Family and domain databases
Gene3D	3.30.420.110. 1 hit. 3.40.1170.10. 1 hit.
HAMAP	MF_00096. MutS.
InterPro	IPR005748. DNA_mismatch_repair_MutS-1. IPR007695. DNA_mismatch_repair_MutS-lik_N. IPR000432. DNA_mismatch_repair_MutS_C. IPR007861. DNA_mismatch_repair_MutS_clamp. IPR007696. DNA_mismatch_repair_MutS_core. IPR016151. DNA_mismatch_repair_MutS_N. IPR007860. DNA_mmatch_repair_MutS_con_dom. IPR027417. P-loop_NTPase. [Graphical view]
PANTHER	PTHR11361:SF34. PTHR11361:SF34. 1 hit.
Pfam	PF01624. MutS_I. 1 hit. PF05188. MutS_II. 1 hit. PF05192. MutS_III. 1 hit. PF05190. MutS_IV. 1 hit. PF00488. MutS_V. 1 hit. [Graphical view]
SMART	SM00534. MUTSac. 1 hit. SM00533. MUTSd. 1 hit. [Graphical view]
SUPFAM	SSF53150. DNA_mismatch_repair_MutS_connt. 1 hit. SSF55271. DNA_mismatch_repair_MutS_N. 1 hit. SSF48334. DNA_repair_MutS_domIII. 1 hit. SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR01070. mutS1. 1 hit.
PROSITE	PS00486. DNA_MISMATCH_REPAIR_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MUTS_RICCN

Accession

Primary (citable) accession number: Q92IL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	December 1, 2001
Last modified:	May 29, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program