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Q92IK8

- SYH_RICCN

UniProt

Q92IK8 - SYH_RICCN

Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (16 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. histidine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidine--tRNA ligaseUniRule annotation (EC:6.1.1.21UniRule annotation)
    Alternative name(s):
    Histidyl-tRNA synthetaseUniRule annotation
    Short name:
    HisRSUniRule annotation
    Gene namesi
    Name:hisSUniRule annotation
    Ordered Locus Names:RC0412
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 414414Histidine--tRNA ligasePRO_0000136238Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272944.RC0412.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92IK8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0124.
    HOGENOMiHOG000018072.
    KOiK01892.
    OMAiCGGGNFK.
    OrthoDBiEOG6BPDH4.

    Family and domain databases

    Gene3Di3.40.50.800. 1 hit.
    HAMAPiMF_00127. His_tRNA_synth.
    InterProiIPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR015807. His-tRNA-ligase.
    IPR004516. HisRS/HisZ.
    [Graphical view]
    PANTHERiPTHR11476. PTHR11476. 1 hit.
    PfamiPF03129. HGTP_anticodon. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
    SUPFAMiSSF52954. SSF52954. 1 hit.
    TIGRFAMsiTIGR00442. hisS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92IK8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEKLQPLRG MKDLLPDDYK VHDYIINKAR DVGVLYGYKQ MSTPIVEYTK    50
    VFNRSMGESS DVISKEIYSF LDKSNDFVAL RPEFTACIIR SLISNRLQHK 100
    LPLKFFSTGP VFRYDRPQAG RQRQFHQLNY EYIGAKGAIT DADTLKLAVD 150
    ILKALEIEQD TTLELNSLGC NESRSVYQQK LVEYLNDFKD QLSEESKIRL 200
    SKNPMRILDS KSETDQKIIA NAPVLSEYYT DESKEYFEEL IQYLDILGVK 250
    YSINPRLVRG LDYYCHTAFE FTTKKLGSQS TILAGGRYDG LAKIMGNNDD 300
    VPAIGFAAGI ERIALMREYN ISEVKPVFVL PIGKNNICYA LEIVDKLRTE 350
    NIAIIIESLG KIAKRMQRIF NENAQFIIFI GDEEQANNNL KIKDLKKAEE 400
    YIVDFAKALE LLKK 414
    Length:414
    Mass (Da):47,455
    Last modified:June 16, 2003 - v2
    Checksum:i44EC0925E8C131E9
    GO

    Sequence cautioni

    The sequence AAL02950.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02950.1. Different initiation.
    PIRiD97751.
    RefSeqiNP_360049.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL02950; AAL02950; RC0412.
    GeneIDi927559.
    KEGGirco:RC0412.
    PATRICi17888023. VBIRicCon45613_0467.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02950.1 . Different initiation.
    PIRi D97751.
    RefSeqi NP_360049.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92IK8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0412.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL02950 ; AAL02950 ; RC0412 .
    GeneIDi 927559.
    KEGGi rco:RC0412.
    PATRICi 17888023. VBIRicCon45613_0467.

    Phylogenomic databases

    eggNOGi COG0124.
    HOGENOMi HOG000018072.
    KOi K01892.
    OMAi CGGGNFK.
    OrthoDBi EOG6BPDH4.

    Family and domain databases

    Gene3Di 3.40.50.800. 1 hit.
    HAMAPi MF_00127. His_tRNA_synth.
    InterProi IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR015807. His-tRNA-ligase.
    IPR004516. HisRS/HisZ.
    [Graphical view ]
    PANTHERi PTHR11476. PTHR11476. 1 hit.
    Pfami PF03129. HGTP_anticodon. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001549. His-tRNA_synth. 1 hit.
    SUPFAMi SSF52954. SSF52954. 1 hit.
    TIGRFAMsi TIGR00442. hisS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiSYH_RICCN
    AccessioniPrimary (citable) accession number: Q92IK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: June 16, 2003
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Rickettsia conorii
      (strain Malish 7): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3