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Q92IK8

- SYH_RICCN

UniProt

Q92IK8 - SYH_RICCN

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Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. histidine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligaseUniRule annotation (EC:6.1.1.21UniRule annotation)
Alternative name(s):
Histidyl-tRNA synthetaseUniRule annotation
Short name:
HisRSUniRule annotation
Gene namesi
Name:hisSUniRule annotation
Ordered Locus Names:RC0412
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Histidine--tRNA ligasePRO_0000136238Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272944.RC0412.

Structurei

3D structure databases

ProteinModelPortaliQ92IK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0124.
HOGENOMiHOG000018072.
KOiK01892.
OMAiCGGGNFK.
OrthoDBiEOG6BPDH4.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92IK8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEKLQPLRG MKDLLPDDYK VHDYIINKAR DVGVLYGYKQ MSTPIVEYTK
60 70 80 90 100
VFNRSMGESS DVISKEIYSF LDKSNDFVAL RPEFTACIIR SLISNRLQHK
110 120 130 140 150
LPLKFFSTGP VFRYDRPQAG RQRQFHQLNY EYIGAKGAIT DADTLKLAVD
160 170 180 190 200
ILKALEIEQD TTLELNSLGC NESRSVYQQK LVEYLNDFKD QLSEESKIRL
210 220 230 240 250
SKNPMRILDS KSETDQKIIA NAPVLSEYYT DESKEYFEEL IQYLDILGVK
260 270 280 290 300
YSINPRLVRG LDYYCHTAFE FTTKKLGSQS TILAGGRYDG LAKIMGNNDD
310 320 330 340 350
VPAIGFAAGI ERIALMREYN ISEVKPVFVL PIGKNNICYA LEIVDKLRTE
360 370 380 390 400
NIAIIIESLG KIAKRMQRIF NENAQFIIFI GDEEQANNNL KIKDLKKAEE
410
YIVDFAKALE LLKK
Length:414
Mass (Da):47,455
Last modified:June 16, 2003 - v2
Checksum:i44EC0925E8C131E9
GO

Sequence cautioni

The sequence AAL02950.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL02950.1. Different initiation.
PIRiD97751.
RefSeqiNP_360049.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL02950; AAL02950; RC0412.
GeneIDi927559.
KEGGirco:RC0412.
PATRICi17888023. VBIRicCon45613_0467.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL02950.1 . Different initiation.
PIRi D97751.
RefSeqi NP_360049.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92IK8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC0412.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL02950 ; AAL02950 ; RC0412 .
GeneIDi 927559.
KEGGi rco:RC0412.
PATRICi 17888023. VBIRicCon45613_0467.

Phylogenomic databases

eggNOGi COG0124.
HOGENOMi HOG000018072.
KOi K01892.
OMAi CGGGNFK.
OrthoDBi EOG6BPDH4.

Family and domain databases

Gene3Di 3.40.50.800. 1 hit.
HAMAPi MF_00127. His_tRNA_synth.
InterProi IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view ]
PANTHERi PTHR11476. PTHR11476. 1 hit.
Pfami PF03129. HGTP_anticodon. 1 hit.
[Graphical view ]
PIRSFi PIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMi SSF52954. SSF52954. 1 hit.
TIGRFAMsi TIGR00442. hisS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiSYH_RICCN
AccessioniPrimary (citable) accession number: Q92IK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: October 29, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Rickettsia conorii
    (strain Malish 7): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3