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Q92IJ0

- DHAS_RICCN

UniProt

Q92IJ0 - DHAS_RICCN

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Protein
Aspartate-semialdehyde dehydrogenase
Gene
asd, RC0430
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate By similarity.UniRule annotation

Catalytic activityi

L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei101 – 1011Phosphate By similarity
Active sitei132 – 1321Acyl-thioester intermediate By similarity
Binding sitei159 – 1591Substrate By similarity
Binding sitei187 – 1871NADP; via carbonyl oxygen By similarity
Binding sitei216 – 2161Phosphate By similarity
Binding sitei237 – 2371Substrate By similarity
Active sitei244 – 2441Proton acceptor By similarity
Binding sitei317 – 3171NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 164NADP By similarity
Nucleotide bindingi41 – 422NADP By similarity
Nucleotide bindingi162 – 1632NADP By similarity

GO - Molecular functioni

  1. N-acetyl-gamma-glutamyl-phosphate reductase activity Source: InterPro
  2. NAD binding Source: InterPro
  3. NADP binding Source: UniProtKB-HAMAP
  4. aspartate-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' L-methionine biosynthetic process Source: UniProtKB-HAMAP
  2. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
  3. isoleucine biosynthetic process Source: InterPro
  4. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
  5. threonine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis, Methionine biosynthesis, Threonine biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00034; UER00016.
UPA00050; UER00463.
UPA00051; UER00464.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate-semialdehyde dehydrogenase (EC:1.2.1.11)
Short name:
ASA dehydrogenase
Short name:
ASADH
Alternative name(s):
Aspartate-beta-semialdehyde dehydrogenase
Gene namesi
Name:asd
Ordered Locus Names:RC0430
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Aspartate-semialdehyde dehydrogenaseUniRule annotation
PRO_0000280938Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272944.RC0430.

Structurei

3D structure databases

ProteinModelPortaliQ92IJ0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0136.
HOGENOMiHOG000013357.
KOiK00133.
OMAiNDPKKFP.
OrthoDBiEOG6JB158.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_02121. ASADH.
InterProiIPR012080. Asp_semialdehyde_DH.
IPR005986. Asp_semialdehyde_DH_beta.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view]
PfamiPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
PIRSFiPIRSF000148. ASA_dh. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01296. asd_B. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92IJ0-1 [UniParc]FASTAAdd to Basket

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MTKKYNIAVI GATGNVGRET LNILAERNFP INKVYAIASD SSLGREVSFG    50
EKILQINSLK SLHFDDIDIA FFCAGSEVSK EFIPKATASN CVVIDKSSLF 100
RVDNQVPLIV PEVNLSTLKE FNTKNIIANP NCIVIPLAVA LKPLDNEIKI 150
KRVVISTYQS VSGAGKAGMD ELYDQTKSKY VFGENDPKKF PKQIAFNIFP 200
HIGDLNKDGY TSEEAKIASE LNKIIGNHFK ASVTSVRVPV FIGHSISVNI 250
EFNDKIDAKE VEEILQDADG IVTISNNNYL AYISPVEVVG EDAVYVSRIR 300
NDVSRDNTIN LWITCDNLRK GAALNSVQIA EELINNYL 338
Length:338
Mass (Da):37,292
Last modified:December 1, 2001 - v1
Checksum:iACADBDF54967BB16
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL02968.1.
PIRiF97753.
RefSeqiNP_360067.1. NC_003103.1.
WP_010977078.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL02968; AAL02968; RC0430.
GeneIDi927572.
KEGGirco:RC0430.
PATRICi17888063. VBIRicCon45613_0487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL02968.1 .
PIRi F97753.
RefSeqi NP_360067.1. NC_003103.1.
WP_010977078.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92IJ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC0430.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL02968 ; AAL02968 ; RC0430 .
GeneIDi 927572.
KEGGi rco:RC0430.
PATRICi 17888063. VBIRicCon45613_0487.

Phylogenomic databases

eggNOGi COG0136.
HOGENOMi HOG000013357.
KOi K00133.
OMAi NDPKKFP.
OrthoDBi EOG6JB158.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00016 .
UPA00050 ; UER00463 .
UPA00051 ; UER00464 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_02121. ASADH.
InterProi IPR012080. Asp_semialdehyde_DH.
IPR005986. Asp_semialdehyde_DH_beta.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view ]
Pfami PF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view ]
PIRSFi PIRSF000148. ASA_dh. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01296. asd_B. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiDHAS_RICCN
AccessioniPrimary (citable) accession number: Q92IJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia conorii
    (strain Malish 7): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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