Q92II0 (LPXB_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase
EC=2.4.1.182

Gene names

Name:	lpxB
Ordered Locus Names:	RC0440

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia conorii

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392
Sequence similarities	Belongs to the LpxB family. Contains 1 RPE3 insert domain.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 446	446	Lipid-A-disaccharide synthase HAMAP-Rule MF_00392		PRO_0000190181
Regions
	Domain	379 – 418	40	RPE3 insert

Sequences

	Sequence		Length	Mass (Da)
	Q92II0 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: FD5F11728238FDB7	FASTA	446	50,738
	10 20 30 40 50 60 MIKIYFIAGE VSGDFVGGRI MQHLKNNTGV QLNSPVSSFV NDAVQFVGVG GKYMEEAGSF 70 80 90 100 110 120 KSLFPITSIN LMGFVEILPH IFKLKKLIDK TVEDIINSKA DLLITIDSPG FTYRVAKRVR 130 140 150 160 170 180 KLLPKLKMIH IVAPSVWAYK EGRAVKYAKI YDCLFALLPF EPPYFTKVGL DCRYIGHPIM 190 200 210 220 230 240 EQEFYSDKIA LREEFKIDEN ERVLCVTLGS RKGEILRHLS VFVSSIEEIF KSCNNLKVIF 250 260 270 280 290 300 TLANPAHEAI IKPFLEDVKF NYLFSSERLK IYAVADVALA KSGTNTLEIA ASGTPMIVAY 310 320 330 340 350 360 KVNLISFFII RLLIKIKYVT LINIIADKEI IPEFIQFNCR ANLISNKLQE LLFNSKKAYE 370 380 390 400 410 420 QVIESQKILQ QLGFKSNRLQ LNSESFRHDE FKGKLARCTK VREHRLSLEN SLVSSDRDDA 430 440 VPSYIAAAII KQEFLEPKIK LLKEKD

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL02978.1.
PIR	H97754.
RefSeq	NP_360077.1. NC_003103.1.
3D structure databases
ProteinModelPortal	Q92II0.
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC0440.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Proteomic databases
PRIDE	Q92II0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL02978; AAL02978; RC0440.
GeneID	928676.
KEGG	rco:RC0440.
PATRIC	17888085. VBIRicCon45613_0498.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HOG000018004.
KO	K00748.
OMA	PTVWAWR.
ProtClustDB	PRK00025.
Enzyme and pathway databases
UniPathway	UPA00359; UER00481.
Family and domain databases
HAMAP	MF_00392. LpxB. Divergent sequence.
InterPro	IPR003835. Glyco_trans_19. IPR022437. RPE3. [Graphical view]
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. lpxB. 1 hit. TIGR03775. RPE3. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXB_RICCN

Accession

Primary (citable) accession number: Q92II0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	December 1, 2001
Last modified:	May 29, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program