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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:RC0440
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Lipid-A-disaccharide synthasePRO_0000190181Add
BLAST

Proteomic databases

PRIDEiQ92II0.

Interactioni

Protein-protein interaction databases

STRINGi272944.RC0440.

Structurei

3D structure databases

ProteinModelPortaliQ92II0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini379 – 41840RPE3 insertAdd
BLAST

Sequence similaritiesi

Belongs to the LpxB family.Curated
Contains 1 RPE3 insert domain.Curated

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiAPQEWAW.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
IPR022437. RPE3.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.
TIGR03775. RPE3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92II0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKIYFIAGE VSGDFVGGRI MQHLKNNTGV QLNSPVSSFV NDAVQFVGVG
60 70 80 90 100
GKYMEEAGSF KSLFPITSIN LMGFVEILPH IFKLKKLIDK TVEDIINSKA
110 120 130 140 150
DLLITIDSPG FTYRVAKRVR KLLPKLKMIH IVAPSVWAYK EGRAVKYAKI
160 170 180 190 200
YDCLFALLPF EPPYFTKVGL DCRYIGHPIM EQEFYSDKIA LREEFKIDEN
210 220 230 240 250
ERVLCVTLGS RKGEILRHLS VFVSSIEEIF KSCNNLKVIF TLANPAHEAI
260 270 280 290 300
IKPFLEDVKF NYLFSSERLK IYAVADVALA KSGTNTLEIA ASGTPMIVAY
310 320 330 340 350
KVNLISFFII RLLIKIKYVT LINIIADKEI IPEFIQFNCR ANLISNKLQE
360 370 380 390 400
LLFNSKKAYE QVIESQKILQ QLGFKSNRLQ LNSESFRHDE FKGKLARCTK
410 420 430 440
VREHRLSLEN SLVSSDRDDA VPSYIAAAII KQEFLEPKIK LLKEKD
Length:446
Mass (Da):50,738
Last modified:December 1, 2001 - v1
Checksum:iFD5F11728238FDB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL02978.1.
PIRiH97754.
RefSeqiNP_360077.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL02978; AAL02978; RC0440.
GeneIDi928676.
KEGGirco:RC0440.
PATRICi17888085. VBIRicCon45613_0498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL02978.1.
PIRiH97754.
RefSeqiNP_360077.1. NC_003103.1.

3D structure databases

ProteinModelPortaliQ92II0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272944.RC0440.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Proteomic databases

PRIDEiQ92II0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL02978; AAL02978; RC0440.
GeneIDi928676.
KEGGirco:RC0440.
PATRICi17888085. VBIRicCon45613_0498.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiAPQEWAW.
OrthoDBiEOG6FBWZR.

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
IPR022437. RPE3.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.
TIGR03775. RPE3. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiLPXB_RICCN
AccessioniPrimary (citable) accession number: Q92II0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: December 1, 2001
Last modified: February 4, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia conorii
    (strain Malish 7): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.