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Q92II0

- LPXB_RICCN

UniProt

Q92II0 - LPXB_RICCN

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthase (EC:2.4.1.182)
    Gene namesi
    Name:lpxB
    Ordered Locus Names:RC0440
    OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
    Taxonomic identifieri272944 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000816: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446Lipid-A-disaccharide synthasePRO_0000190181Add
    BLAST

    Proteomic databases

    PRIDEiQ92II0.

    Interactioni

    Protein-protein interaction databases

    STRINGi272944.RC0440.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92II0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini379 – 41840RPE3 insertAdd
    BLAST

    Sequence similaritiesi

    Belongs to the LpxB family.Curated
    Contains 1 RPE3 insert domain.Curated

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    IPR022437. RPE3.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.
    TIGR03775. RPE3. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q92II0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKIYFIAGE VSGDFVGGRI MQHLKNNTGV QLNSPVSSFV NDAVQFVGVG    50
    GKYMEEAGSF KSLFPITSIN LMGFVEILPH IFKLKKLIDK TVEDIINSKA 100
    DLLITIDSPG FTYRVAKRVR KLLPKLKMIH IVAPSVWAYK EGRAVKYAKI 150
    YDCLFALLPF EPPYFTKVGL DCRYIGHPIM EQEFYSDKIA LREEFKIDEN 200
    ERVLCVTLGS RKGEILRHLS VFVSSIEEIF KSCNNLKVIF TLANPAHEAI 250
    IKPFLEDVKF NYLFSSERLK IYAVADVALA KSGTNTLEIA ASGTPMIVAY 300
    KVNLISFFII RLLIKIKYVT LINIIADKEI IPEFIQFNCR ANLISNKLQE 350
    LLFNSKKAYE QVIESQKILQ QLGFKSNRLQ LNSESFRHDE FKGKLARCTK 400
    VREHRLSLEN SLVSSDRDDA VPSYIAAAII KQEFLEPKIK LLKEKD 446
    Length:446
    Mass (Da):50,738
    Last modified:December 1, 2001 - v1
    Checksum:iFD5F11728238FDB7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02978.1.
    PIRiH97754.
    RefSeqiNP_360077.1. NC_003103.1.

    Genome annotation databases

    EnsemblBacteriaiAAL02978; AAL02978; RC0440.
    GeneIDi928676.
    KEGGirco:RC0440.
    PATRICi17888085. VBIRicCon45613_0498.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006914 Genomic DNA. Translation: AAL02978.1 .
    PIRi H97754.
    RefSeqi NP_360077.1. NC_003103.1.

    3D structure databases

    ProteinModelPortali Q92II0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272944.RC0440.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Proteomic databases

    PRIDEi Q92II0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL02978 ; AAL02978 ; RC0440 .
    GeneIDi 928676.
    KEGGi rco:RC0440.
    PATRICi 17888085. VBIRicCon45613_0498.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    IPR022437. RPE3.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    TIGR03775. RPE3. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-613 / Malish 7.

    Entry informationi

    Entry nameiLPXB_RICCN
    AccessioniPrimary (citable) accession number: Q92II0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia conorii
      (strain Malish 7): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3