Reviewed, UniProtKB/Swiss-Prot Q92ID5 (NUOA_RICCN)

Names and origin

Protein names

Recommended name:
    NADH-quinone oxidoreductase subunit A
    EC=1.6.99.5
Alternative name(s):
    NADH dehydrogenase I subunit A
    NDH-1 subunit A

Gene names

Name:	nuoA
Ordered Locus Names:	RC0485

Organism

Rickettsia conorii [Complete proteome] [HAMAP]

Taxonomic identifier

781 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	123 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NADH + quinone = NAD(+) + quinol.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the complex I subunit 3 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mitochondrial electron transport, NADH to ubiquinone Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 123	123	NADH-quinone oxidoreductase subunit A		PRO_0000117875
Regions
	Transmembrane	11 – 31	21	Potential
	Transmembrane	68 – 88	21	Potential
	Transmembrane	93 – 113	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q92ID5-1 [UniParc]. Last modified January 23, 2002. Version 2. Checksum: 5395664436F056AC	FASTA	123	14,242
	10 20 30 40 50 60 MLQNSELLQE YLPIAIFFGI AVLVSGLIMI LPNLLSTKKY NKDKLEPYEC GFEPFSDARS 70 80 90 100 110 120 KFDICFYLVA ILFIIFDLEI AFLVPWAISL NTIGKIGFFS MMFFLFVLII GFIYEWKKGA LDW

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed: 11557893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE008611 Genomic DNA. Translation: AAL03023.1. Different initiation.
PIR	E97760.
RefSeq	NP_360122.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	928710.
GenomeReviews	Gene locus RC0485 in contig AE006914_GR.
KEGG	rco:RC0485.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q92ID5.
Enzyme and pathway databases
BioCyc	RCON272944:RC0485-MON.
Family and domain databases
InterPro	IPR000440. Oxidored_q4. [Graphical view]
PANTHER	PTHR11058. Oxidored_q4. 1 hit.
Pfam	PF00507. Oxidored_q4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUOA_RICCN

Accession

Primary (citable) accession number: Q92ID5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	January 23, 2002
Last modified:	November 25, 2008
This is version 41 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)