Q92IC9 (XERD_RICCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine recombinase XerD

Gene names

Name:	xerD
Ordered Locus Names:	RC0491

Organism

Rickettsia conorii (strain ATCC VR-613 / Malish 7) [Complete proteome] [HAMAP]

Taxonomic identifier

272944 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia conorii

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids By similarity. HAMAP-Rule MF_01807
Subunit structure	Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the 'phage' integrase family. XerD subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Chromosome partition DNA integration DNA recombination
Cellular component	Cytoplasm
Ligand	DNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA integration Inferred from electronic annotation. Source: UniProtKB-KW DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW chromosome segregation Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Tyrosine recombinase XerD HAMAP-Rule MF_01807		PRO_0000095410
Sites
	Active site	145	1	By similarity
	Active site	176	1	By similarity
	Active site	251	1	By similarity
	Active site	254	1	By similarity
	Active site	277	1	By similarity
	Active site	286	1	O-(3'-phospho-DNA)-tyrosine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92IC9 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 734AA7CCECA351AC	FASTA	306	34,699
	10 20 30 40 50 60 MGFIAQFLEM LLAERALSKN SILSYKRDLF DFQNYLAKHK LSELNITTEN IRDWIEYLAS 70 80 90 100 110 120 NDLQARSINR KISTIKSYYE FLISENHTAF NPVLNVDLPK YQNKLPEILS IAQIKSLLEH 130 140 150 160 170 180 CSQDNSPEGI RLNAMIHLLY ASGLRVSELV SLKLADILTN KTSKGEVRKI FSVLGKGNKE 190 200 210 220 230 240 RVIVINEQAV ISIAKYLTIR GVFVNKAKPR NLIYLFPSSA LAGYMTRQNF AILLKSAALY 250 260 270 280 290 300 AGLNPEYISP HILRHSFASH LLEGGADLRV IQELLGHADI STTQIYTHLQ TNHLKKALLR HPLNKN

References

[1]

"Mechanisms of evolution in Rickettsia conorii and R. prowazekii." Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D. Science 293:2093-2098(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-613 / Malish 7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006914 Genomic DNA. Translation: AAL03029.1.
PIR	C97761.
RefSeq	NP_360128.1. NC_003103.1.
3D structure databases
ProteinModelPortal	Q92IC9.
ModBase	Search...
Protein-protein interaction databases
STRING	272944.RC0491.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL03029; AAL03029; RC0491.
GeneID	927615.
KEGG	rco:RC0491.
PATRIC	17888218. VBIRicCon45613_0562.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4974.
HOGENOM	HOG000045296.
KO	K04763.
OMA	PEHISPH.
ProtClustDB	PRK00283.
Family and domain databases
Gene3D	1.10.150.130. 1 hit. 1.10.443.10. 1 hit.
HAMAP	MF_01807. Recomb_XerD.
InterPro	IPR011010. DNA_brk_join_enz. IPR013762. Integrase-like_cat-core. IPR002104. Integrase_catalytic. IPR010998. Integrase_Lambda-type_N. IPR023109. Integrase_recombinase_N. IPR004107. Integrase_SAM-like_N. IPR011932. Recomb_XerD. IPR023009. Tyrosine_recombinase_XerC/XerD. [Graphical view]
Pfam	PF02899. Phage_integr_N. 1 hit. PF00589. Phage_integrase. 1 hit. [Graphical view]
SUPFAM	SSF56349. DNA_brk_join_enz. 1 hit. SSF47823. L_intgrse_like_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

XERD_RICCN

Accession

Primary (citable) accession number: Q92IC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program