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Q92IC9

- XERD_RICCN

UniProt

Q92IC9 - XERD_RICCN

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Protein

Tyrosine recombinase XerD

Gene

xerD

Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei145 – 1451UniRule annotation
Active sitei176 – 1761UniRule annotation
Active sitei251 – 2511UniRule annotation
Active sitei254 – 2541UniRule annotation
Active sitei277 – 2771UniRule annotation
Active sitei286 – 2861O-(3'-phospho-DNA)-tyrosine intermediateUniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. tyrosine-based site-specific recombinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. chromosome segregation Source: UniProtKB-HAMAP
  4. transposition, DNA-mediated Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, DNA integration, DNA recombination

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine recombinase XerDUniRule annotation
Gene namesi
Name:xerDUniRule annotation
Ordered Locus Names:RC0491
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Tyrosine recombinase XerDPRO_0000095410Add
BLAST

Interactioni

Subunit structurei

Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.UniRule annotation

Protein-protein interaction databases

STRINGi272944.RC0491.

Structurei

3D structure databases

ProteinModelPortaliQ92IC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 'phage' integrase family. XerD subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG4974.
HOGENOMiHOG000045296.
KOiK04763.
OMAiPMGELAI.
OrthoDBiEOG6PZXFP.

Family and domain databases

Gene3Di1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
HAMAPiMF_01807. Recomb_XerD.
MF_01808. Recomb_XerC.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat-core.
IPR002104. Integrase_catalytic.
IPR023109. Integrase_recombinase_N.
IPR004107. Integrase_SAM-like_N.
IPR011932. Recomb_XerD.
IPR023009. Tyrosine_recombinase_XerC/XerD.
[Graphical view]
PfamiPF02899. Phage_int_SAM_1. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92IC9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGFIAQFLEM LLAERALSKN SILSYKRDLF DFQNYLAKHK LSELNITTEN
60 70 80 90 100
IRDWIEYLAS NDLQARSINR KISTIKSYYE FLISENHTAF NPVLNVDLPK
110 120 130 140 150
YQNKLPEILS IAQIKSLLEH CSQDNSPEGI RLNAMIHLLY ASGLRVSELV
160 170 180 190 200
SLKLADILTN KTSKGEVRKI FSVLGKGNKE RVIVINEQAV ISIAKYLTIR
210 220 230 240 250
GVFVNKAKPR NLIYLFPSSA LAGYMTRQNF AILLKSAALY AGLNPEYISP
260 270 280 290 300
HILRHSFASH LLEGGADLRV IQELLGHADI STTQIYTHLQ TNHLKKALLR

HPLNKN
Length:306
Mass (Da):34,699
Last modified:December 1, 2001 - v1
Checksum:i734AA7CCECA351AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL03029.1.
PIRiC97761.
RefSeqiNP_360128.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03029; AAL03029; RC0491.
GeneIDi927615.
KEGGirco:RC0491.
PATRICi17888218. VBIRicCon45613_0562.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006914 Genomic DNA. Translation: AAL03029.1 .
PIRi C97761.
RefSeqi NP_360128.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92IC9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC0491.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL03029 ; AAL03029 ; RC0491 .
GeneIDi 927615.
KEGGi rco:RC0491.
PATRICi 17888218. VBIRicCon45613_0562.

Phylogenomic databases

eggNOGi COG4974.
HOGENOMi HOG000045296.
KOi K04763.
OMAi PMGELAI.
OrthoDBi EOG6PZXFP.

Family and domain databases

Gene3Di 1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
HAMAPi MF_01807. Recomb_XerD.
MF_01808. Recomb_XerC.
InterProi IPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat-core.
IPR002104. Integrase_catalytic.
IPR023109. Integrase_recombinase_N.
IPR004107. Integrase_SAM-like_N.
IPR011932. Recomb_XerD.
IPR023009. Tyrosine_recombinase_XerC/XerD.
[Graphical view ]
Pfami PF02899. Phage_int_SAM_1. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view ]
SUPFAMi SSF56349. SSF56349. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiXERD_RICCN
AccessioniPrimary (citable) accession number: Q92IC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3