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Q92IA0

- MDH_RICCN

UniProt

Q92IA0 - MDH_RICCN

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Protein

Malate dehydrogenase

Gene
mdh, RC0520
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351NAD By similarity
Binding sitei84 – 841Substrate By similarity
Binding sitei90 – 901Substrate By similarity
Binding sitei97 – 971NAD By similarity
Binding sitei122 – 1221Substrate By similarity
Binding sitei153 – 1531Substrate By similarity
Active sitei177 – 1771Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NAD By similarity
Nucleotide bindingi120 – 1223NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:RC0520
OrganismiRickettsia conorii (strain ATCC VR-613 / Malish 7)
Taxonomic identifieri272944 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000816: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Malate dehydrogenaseUniRule annotationPRO_0000113467Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272944.RC0520.

Structurei

3D structure databases

ProteinModelPortaliQ92IA0.
SMRiQ92IA0. Positions 1-314.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiYGQNDIC.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92IA0-1 [UniParc]FASTAAdd to Basket

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MKQNAKISLI GSGNIGGTLA HLISLRELGD IVLFDVTEGV PQGKALDLMQ    50
AGTIAGSDIK IKGTNDYKDI EGSDAIIITA GLPRKPGMSR EDLISINTGI 100
MKTVAANVKK YAPDAFVIVI TNPLDVMVYV MLKESGLPHN KVIGMAGVLD 150
SSRFNLFLAE EFKVSVNNVN SMVLGGHGDA MVPLARYSTI SGVPIPDLIK 200
MGLSSNENIE KIIDRTRNGG GEIVALLKTG SAYYAPAASA IEMLESYLKD 250
KRQILTCAAH LQGEYGVHDL YVGVPIMIGK EGVLRVIELQ LTAEEKALFD 300
KSVEGVKKLI ETIK 314
Length:314
Mass (Da):33,638
Last modified:December 1, 2001 - v1
Checksum:i27F016CDE3EF6F14
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03058.1.
PIRiH97764.
RefSeqiNP_360157.1. NC_003103.1.
WP_010977159.1. NC_003103.1.

Genome annotation databases

EnsemblBacteriaiAAL03058; AAL03058; RC0520.
GeneIDi927642.
KEGGirco:RC0520.
PATRICi17888282. VBIRicCon45613_0594.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006914 Genomic DNA. Translation: AAL03058.1 .
PIRi H97764.
RefSeqi NP_360157.1. NC_003103.1.
WP_010977159.1. NC_003103.1.

3D structure databases

ProteinModelPortali Q92IA0.
SMRi Q92IA0. Positions 1-314.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272944.RC0520.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL03058 ; AAL03058 ; RC0520 .
GeneIDi 927642.
KEGGi rco:RC0520.
PATRICi 17888282. VBIRicCon45613_0594.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi YGQNDIC.
OrthoDBi EOG6091FG.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-613 / Malish 7.

Entry informationi

Entry nameiMDH_RICCN
AccessioniPrimary (citable) accession number: Q92IA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia conorii
    (strain Malish 7): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi